Assessment of Structural Intolerance and Durability
General Structure Information 3uk6 RUVBL2 crystal structure of the tip48 (tip49b) hexamer 2.95Å AUTH M.PETUKHOV,A.DAGKESSAMANSKAJA,M.BOMMER,T.BARRETT,I.TSANEVA,AUTH 2 A.YAKIMOV,R.QUEVAL,A.SHVETSOV,M.KHODORKOVSKIY,E.KAS,AUTH 3 M.GRIGORIEVTITL LARGE-SCALE CONFORMATIONAL FLEXIBILITY DETERMINES THETITL 2 PROPERTIES OF AAA+ TIP49 ATPASES.REF STRUCTURE V. 20 1321 2012REFN ISSN 0969-2126PMID 22748767DOI 10.1016/J.STR.2012.05.012 Variant Set Distributions Mapped Variants
General Structure Information 2zmf PDE10A crystal structure of the c-terminal gaf domain of human phosphodiesterase 10a 2.1Å AUTH N.HANDA,E.MIZOHATA,S.KISHISHITA,M.TOYAMA,S.MORITA,AUTH 2 T.UCHIKUBO-KAMO,R.AKASAKA,K.OMORI,J.KOTERA,T.TERADA,AUTH 3 M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE GAF-B DOMAIN FROM HUMANTITL 2 PHOSPHODIESTERASE 10A COMPLEXED WITH ITS LIGAND, CAMPREF J.BIOL.CHEM. V. 283 19657 2008REFN ISSN 0021-9258PMID 18477562DOI 10.1074/JBC.M800595200 Variant Set Distributions Mapped Variants
General Structure Information 3c5w PPME1 complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme 2.8Å AUTH Y.XING,Z.LI,Y.CHEN,J.B.STOCK,P.D.JEFFREY,Y.SHITITL STRUCTURAL MECHANISM OF DEMETHYLATION AND INACTIVATION OFTITL 2 PROTEIN PHOSPHATASE 2A.REF CELL(CAMBRIDGE,MASS.) V. 133 154 2008REFN ISSN 0092-8674PMID 18394995DOI 10.1016/J.CELL.2008.02.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4ael PDE10A pde10a in complex with the inhibitor az5 2.2Å AUTH U.BAUER,F.GIORDANETTO,M.BAUER,G.OMAHONY,K.E.JOHANSSON,AUTH 2 W.KNECHT,J.HARTLEIB-GESCHWINDNER,E.T.CARLSSON,C.ENROTHTITL DISCOVERY OF 4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILETITL 2 DERIVATIVES AS NOVEL PDE10A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 1944 2012REFN ISSN 0960-894XPMID 22321214DOI 10.1016/J.BMCL.2012.01.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nyt APOBEC2 the apobec2 crystal structure and functional implications for aid 2.5Å AUTH C.PROCHNOW,R.BRANSTEITTER,M.G.KLEIN,M.F.GOODMAN,AUTH 2 X.S.CHENTITL THE APOBEC-2 CRYSTAL STRUCTURE AND FUNCTIONALTITL 2 IMPLICATIONS FOR THE DEAMINASE AID.REF NATURE V. 445 447 2007REFN ISSN 0028-0836PMID 17187054DOI 10.1038/NATURE05492 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3enp TPRKB crystal structure of human cgi121 2.48Å AUTH D.Y.MAO,D.NECULAI,M.DOWNEY,S.ORLICKY,Y.Z.HAFFANI,AUTH 2 D.F.CECCARELLI,J.S.HO,R.K.SZILARD,W.ZHANG,C.S.HO,L.WAN,AUTH 3 C.FARES,S.RUMPEL,I.KURINOV,C.H.ARROWSMITH,D.DUROCHER,AUTH 4 F.SICHERITITL ATOMIC STRUCTURE OF THE KEOPS COMPLEX: AN ANCIENT PROTEINTITL 2 KINASE-CONTAINING MOLECULAR MACHINE.REF MOL.CELL V. 32 259 2008REFN ISSN 1097-2765PMID 18951093DOI 10.1016/J.MOLCEL.2008.10.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2eb1 DICER1 crystal structure of the c-terminal rnase iii domain of human dicer 2.0Å AUTH D.TAKESHITA,S.ZENNO,W.C.LEE,K.NAGATA,K.SAIGO,M.TANOKURATITL HOMODIMERIC STRUCTURE AND DOUBLE-STRANDED RNA CLEAVAGETITL 2 ACTIVITY OF THE C-TERMINAL RNASE III DOMAIN OF HUMAN DICERREF J.MOL.BIOL. V. 374 106 2007REFN ISSN 0022-2836PMID 17920623DOI 10.1016/J.JMB.2007.08.069 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4ncs NEU2 human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate) 2.2Å AUTH S.BUCHINI,F.X.GALLAT,I.R.GREIG,J.H.KIM,S.WAKATSUKI,AUTH 2 L.M.CHAVAS,S.G.WITHERSTITL TUNING MECHANISM-BASED INACTIVATORS OF NEURAMINIDASES:TITL 2 MECHANISTIC AND STRUCTURAL INSIGHTS.REF ANGEW.CHEM.INT.ED.ENGL. V. 53 3382 2014REFN ISSN 1433-7851PMID 24591206DOI 10.1002/ANIE.201309675 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lna AFG3L2 solution nmr structure of the mitochondrial inner membrane domain (residues 164-251), ftsh_ext, from the paraplegin-like protein afg3l2 from homo sapiens, northeast structural genomics consortium target hr6741a -1.0Å AUTH T.A.RAMELOT,Y.YANG,I.D.SAHU,H.W.LEE,R.XIAO,G.A.LORIGAN,AUTH 2 G.T.MONTELIONE,M.A.KENNEDYTITL NMR STRUCTURE AND MD SIMULATIONS OF THE AAA PROTEASETITL 2 INTERMEMBRANE SPACE DOMAIN INDICATES PERIPHERAL MEMBRANETITL 3 LOCALIZATION WITHIN […]