General Structure Information 4n3b HCFC1 crystal structure of human o-glcnac transferase bound to a peptide from hcf-1 pro-repeat2(1-26)e10q and udp-5sglcnac 2.17Å AUTH M.B.LAZARUS,J.JIANG,V.KAPURIA,T.BHUIYAN,J.JANETZKO,AUTH 2 W.F.ZANDBERG,D.J.VOCADLO,W.HERR,S.WALKERTITL HCF-1 IS CLEAVED IN THE ACTIVE SITE OF O-GLCNAC TRANSFERASE.REF SCIENCE V. 342 1235 2013REFN ISSN 0036-8075PMID 24311690DOI 10.1126/SCIENCE.1243990 Variant Set Distributions Mapped Variants
General Structure Information 3t7o GYG1 crystal structure of human glycogenin-1 (gyg1) complexed with manganese, udp-glucose and glucose 1.85Å AUTH A.CHAIKUAD,D.S.FROESE,G.BERRIDGE,F.VON DELFT,U.OPPERMANN,AUTH 2 W.W.YUETITL CONFORMATIONAL PLASTICITY OF GLYCOGENIN AND ITSTITL 2 MALTOSACCHARIDE SUBSTRATE DURING GLYCOGEN BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 108 21028 2011REFN ISSN 0027-8424PMID 22160680DOI 10.1073/PNAS.1113921108 Variant Set Distributions Mapped Variants
General Structure Information 4eeg B4GALT1 crystal structure of human m340h-beta-1,4-galactosyltransferase-1 (m340h-b4gal-t1) in complex with glcnac-beta1,6-gal-beta 2.2Å AUTH B.RAMAKRISHNAN,E.BOEGGEMAN,P.K.QASBATITL BINDING OF N-ACETYLGLUCOSAMINE (GLCNAC) BETA 1-6-BRANCHEDTITL 2 OLIGOSACCHARIDE ACCEPTORS TO BETA 4-GALACTOSYLTRANSFERASE ITITL 3 REVEALS A NEW LIGAND BINDING MODE.REF J.BIOL.CHEM. V. 287 28666 2012REFN ISSN 0021-9258PMID 22740701DOI 10.1074/JBC.M112.373514 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2j0f TYMP structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design 2.31Å AUTH K.EL OMARI,A.BRONCKAERS,S.LIEKENS,M.PEREZ-PEREZ,AUTH 2 J.BALZARINI,D.K.STAMMERSTITL STRUCTURAL BASIS FOR NON-COMPETITIVE PRODUCTTITL 2 INHIBITION IN HUMAN THYMIDINE PHOSPHORYLASE:TITL 3 IMPLICATIONS FOR DRUG DESIGN.REF BIOCHEM.J. V. 399 199 2006REFN ISSN 0264-6021PMID 16803458DOI 10.1042/BJ20060513 Variant Set Distributions Ripley’s K […]
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants
General Structure Information 2wns UMPS human orotate phosphoribosyltransferase (oprtase) domain of uridine 5-monophosphate synthase (umps) in complex with its substrate orotidine 5-monophosphate (omp) 1.9Å AUTH M.MOCHE,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTYENOVA,A.KOTZCH,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,L.TRESAUGUES,S.VANDENBERG,AUTH 7 J.WEIGELT,M.WELIN,M.WISNIEWSKA,P.NORDLUNDTITL HUMAN OROTATE PHOSPHORIBOSYLTRANSFERASE (OPRTASE)TITL 2 DOMAIN OF URIDINE 5-MONOPHOSPHATE SYNTHASE (UMPS)TITL 3 IN COMPLEX WITH ITS SUBSTRATE […]
General Structure Information 3ggs PNP human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2-deoxyadenosine 2.52Å AUTH S.AFSHAR,M.R.SAWAYA,S.L.MORRISONTITL STRUCTURE OF A MUTANT HUMAN PURINE NUCLEOSIDE PHOSPHORYLASETITL 2 WITH THE PRODRUG, 2-FLUORO-2-DEOXYADENOSINE AND THETITL 3 CYTOTOXIC DRUG, 2-FLUOROADENINE.REF PROTEIN SCI. V. 18 1107 2009REFN ISSN 0961-8368PMID 19388075DOI 10.1002/PRO.91 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4gyy OGT crystal structure of human o-glcnac transferase with udp-5sglcnac and a peptide substrate 1.85Å AUTH M.B.LAZARUS,J.JIANG,T.M.GLOSTER,W.F.ZANDBERG,G.E.WHITWORTH,AUTH 2 D.J.VOCADLO,S.WALKERTITL STRUCTURAL SNAPSHOTS OF THE REACTION COORDINATE FOR O-GLCNACTITL 2 TRANSFERASE.REF NAT.CHEM.BIOL. V. 8 966 2012REFN ISSN 1552-4450PMID 23103939DOI 10.1038/NCHEMBIO.1109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]