Assessment of Structural Intolerance and Durability
General Structure Information 4irq B4GALT7 crystal structure of catalytic domain of human beta1, 4galactosyltransferase 7 in closed conformation in complex with manganese and udp 2.3Å AUTH Y.TSUTSUI,B.RAMAKRISHNAN,P.K.QASBATITL CRYSTAL STRUCTURES OF BETA-1,4-GALACTOSYLTRANSFERASE 7TITL 2 ENZYME REVEAL CONFORMATIONAL CHANGES AND SUBSTRATE BINDING.REF J.BIOL.CHEM. V. 288 31963 2013REFN ISSN 0021-9258PMID 24052259DOI 10.1074/JBC.M113.509984 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2jbh PRTFDC1 human phosphoribosyl transferase domain containing 1 1.7Å AUTH M.WELIN,L.EGEBLAD,A.JOHANSSON,P.STENMARK,L.WANG,S.FLODIN,AUTH 2 T.NYMAN,L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,S.ERIKSSON,AUTH 3 H.EKLUND,P.NORDLUNDTITL STRUCTURAL AND FUNCTIONAL STUDIES OF THE HUMANTITL 2 PHOSPHORIBOSYLTRANSFERASE DOMAIN CONTAINING PROTEIN 1.REF FEBS J. V. 277 4920 2010REFN ISSN 1742-464XPMID 21054786DOI 10.1111/J.1742-4658.2010.07897.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2de0 FUT8 crystal structure of human alpha 1,6-fucosyltransferase, fut8 2.61Å AUTH H.IHARA,Y.IKEDA,S.TOMA,X.WANG,T.SUZUKI,J.GU,E.MIYOSHI,AUTH 2 T.TSUKIHARA,K.HONKE,A.MATSUMOTO,A.NAKAGAWA,N.TANIGUCHITITL CRYSTAL STRUCTURE OF MAMMALIANTITL 2 {ALPHA}1,6-FUCOSYLTRANSFERASE, FUT8REF GLYCOBIOLOGY V. 17 455 2007REFN ISSN 0959-6658PMID 17172260DOI 10.1093/GLYCOB/CWL079 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hkv PARP10 human poly(adp-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide 2.1Å AUTH T.KARLBERG,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,AUTH 4 T.KOTENYOVA,A.KOTZSCH,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,J.SAGEMARK,P.SCHUTZ,AUTH 6 M.I.SIPONEN,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 8 H.SCHULERTITL HUMAN POLY(ADP-RIBOSE) POLYMERASE 10, CATALYTICTITL 2 FRAGMENT IN COMPLEX WITH AN INHIBITORTITL 3 3-AMINOBENZAMIDEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 3v2b PARP15 human poly(adp-ribose) polymerase 15 (artd7, bal3), macro domain 2 in complex with adenosine-5-diphosphoribose 2.2Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3blj PARP15 crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ffu GALNT2 crystal structure of human ppgalnact-2 complexed with udp and ea2 1.64Å AUTH T.A.FRITZ,J.RAMAN,L.A.TABAKTITL DYNAMIC ASSOCIATION BETWEEN THE CATALYTIC ANDTITL 2 LECTIN DOMAINS OF HUMAN UDP-GALNAC:POLYPEPTIDETITL 3 {ALPHA}-N-ACETYLGALACTOSAMINYLTRANSFERASE-2REF J.BIOL.CHEM. V. 281 8613 2006REFN ISSN 0021-9258PMID 16434399DOI 10.1074/JBC.M513590200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2ffu GALNT2 crystal structure of human ppgalnact-2 complexed with udp and ea2 1.64Å AUTH T.A.FRITZ,J.RAMAN,L.A.TABAKTITL DYNAMIC ASSOCIATION BETWEEN THE CATALYTIC ANDTITL 2 LECTIN DOMAINS OF HUMAN UDP-GALNAC:POLYPEPTIDETITL 3 {ALPHA}-N-ACETYLGALACTOSAMINYLTRANSFERASE-2REF J.BIOL.CHEM. V. 281 8613 2006REFN ISSN 0021-9258PMID 16434399DOI 10.1074/JBC.M513590200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]