Assessment of Structural Intolerance and Durability
General Structure Information 4hwn FCRLA crystal structure of the second ig-c2 domain of human fc-receptor like a (fcrla), isoform 9 [nysgrc-005836] 2.01Å AUTH P.R.KUMAR,S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF THE SECOND IG-C2 DOMAIN OF THE HUMANTITL 2 FC-RECEPTOR LIKE A, ISOFORM 9 [NYSGRC-005836]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3ihj GPT2 human alanine aminotransferase 2 in complex with plp 2.3Å AUTH M.WISNIEWSKA,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,A.KOTZSCH,M.MOCHE,T.K.NIELSEN,P.NORDLUND,AUTH 5 T.NYMAN,C.PERSSON,A.K.ROOS,P.SCHUTZ,L.SVENSSON,A.G.THORSELL,AUTH 6 L.TRESAUGUES,S.VAN DEN BERG,J.WEIGELT,M.WELIN,H.SCHULERTITL HUMAN GLUTAMATE PYRUVATE TRANSAMINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1wxt EPS8L3 solution structure of the sh3 domain of human hypothetical protein flj21522 -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SH3 DOMAIN OF HUMANTITL 2 HYPOTHETICAL PROTEIN FLJ21522REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3s93 TDRD5 crystal structure of conserved motif in tdrd5 2.28Å AUTH X.CHAO,W.TEMPEL,C.BIAN,J.KANIA,A.K.WERNIMONT,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MINTITL CRYSTAL STRUCTURE OF CONSERVED MOTIF IN TDRD5REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3l11 RNF168 crystal structure of the ring domain of rnf168 2.12Å AUTH S.J.CAMPBELL,R.A.EDWARDS,C.C.LEUNG,D.NECULAI,C.D.HODGE,AUTH 2 S.DHE-PAGANON,J.N.GLOVERTITL MOLECULAR INSIGHTS INTO THE FUNCTION OF RING FINGERTITL 2 (RNF)-CONTAINING PROTEINS HRNF8 AND HRNF168 INTITL 3 UBC13/MMS2-DEPENDENT UBIQUITYLATION.REF J.BIOL.CHEM. V. 287 23900 2012REFN ISSN 0021-9258PMID 22589545DOI 10.1074/JBC.M112.359653 Variant Set Distributions Mapped Variants
General Structure Information 2l0b PJA1 solution nmr structure of zinc finger domain of e3 ubiquitin-protein ligase praja-1 from homo sapiens, northeast structural genomics consortium (nesg) target hr4710b -1.0Å AUTH G.LIU,S.TONG,R.XIAO,T.B.ACTON,J.K.EVERETT,G.T.MONTELIONETITL SOLUTION STRUCTURE OF ZINC FINGER DOMAIN OF E3TITL 2 UBIQUITIN-PROTEIN LIGASE PROTEIN PRAJA-1 FROM HOMO SAPIENS,TITL 3 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 4 HR4710BREF […]
General Structure Information 3cbq REM2 crystal structure of the human rem2 gtpase with bound gdp 1.82Å AUTH L.NEDYALKOVA,Y.SHEN,Y.TONG,W.TEMPEL,F.MACKENZIE,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN REM2 GTPASE WITHTITL 2 BOUND GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3iq7 GSG2 crystal structure of human haspin in complex with 5-iodotubercidin 2.0Å AUTH J.ESWARAN,D.PATNAIK,P.FILIPPAKOPOULOS,F.WANG,R.L.STEIN,AUTH 2 J.W.MURRAY,J.M.HIGGINS,S.KNAPPTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE ATYPICALTITL 2 HUMAN KINASE HASPIN.REF PROC.NATL.ACAD.SCI.USA V. 106 20198 2009REFN ISSN 0027-8424PMID 19918057DOI 10.1073/PNAS.0901989106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2yyo SPRYD3 crystal sturcture of human spry domain 2.0Å AUTH S.KISHISHITA,T.UCHIKUBO-KAMO,K.MURAYAMA,T.TERADA,AUTH 2 L.CHEN,Z.Q.FU,J.CHRZAS,M.SHIROUZU,B.C.WANG,AUTH 3 S.YOKOYAMATITL CRYSTAL STURCTURE OF HUMAN SPRY DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2pla GPD1L crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein 2.51Å AUTH J.UPPENBERG,C.SMEE,V.HOZJAN,K.KAVANAGH,G.BUNKOCZI,AUTH 2 E.PAPAGRIGORIOU,A.C.W.PIKE,E.UGOCHUKWU,C.UMEANO,F.VON DELFT,AUTH 3 J.WEIGELT,C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN GLYCEROL-3-PHOSPHATETITL 2 DEHYDROGENASE 1-LIKE PROTEIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants