Assessment of Structural Intolerance and Durability
General Structure Information 2vpd PYGO1 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 4krf AGO1 structure of human argonaute-1 let-7 complex 2.1Å AUTH C.R.FAEHNLE,E.ELKAYAM,A.D.HAASE,G.J.HANNON,L.JOSHUA-TORTITL THE MAKING OF A SLICER: ACTIVATION OF HUMAN ARGONAUTE-1.REF CELL REP V. 3 1901 2013REFN ESSN 2211-1247PMID 23746446DOI 10.1016/J.CELREP.2013.05.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bld SUFU crystal structure of a human suppressor of fused (sufu)- gli3p complex 2.8Å AUTH A.L.CHERRY,C.FINTA,M.KARLSTROM,Q.JIN,T.SCHWEND,AUTH 2 J.ASTORGA-WELLS,R.A.ZUBAREV,M.DEL CAMPO,A.R.CRISWELL,AUTH 3 D.DE SANCTIS,L.JOVINE,R.TOFTGARDTITL STRUCTURAL BASIS OF SUFU-GLI INTERACTION IN HEDGEHOGTITL 2 SIGNALLING REGULATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2579 2013REFN ISSN 0907-4449PMID 24311597DOI 10.1107/S0907444913028473 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1d9n MBD1 solution structure of the methyl-cpg-binding domain of the methylation-dependent transcriptional repressor mbd1/pcm1 -1.0Å AUTH I.OHKI,N.SHIMOTAKE,N.FUJITA,M.NAKAO,M.SHIRAKAWATITL SOLUTION STRUCTURE OF THE METHYL-CPG-BINDINGTITL 2 DOMAIN OF THE METHYLATION-DEPENDENTTITL 3 TRANSCRIPTIONAL REPRESSOR MBD1.REF EMBO J. V. 18 6653 1999REFN ISSN 0261-4189PMID 10581239DOI 10.1093/EMBOJ/18.23.6653 Variant Set Distributions Mapped Variants
General Structure Information 4c0d CNOT2 structure of the not module of the human ccr4-not complex (cnot1-cnot2-cnot3) 3.2Å AUTH A.BOLAND,Y.CHEN,T.RAISCH,S.JONAS,D.KUZUOGLU-OZTURK,AUTH 2 L.WOHLBOLD,O.WEICHENRIEDER,E.IZAURRALDETITL STRUCTURE AND ASSEMBLY OF THE NOT MODULE OF THE HUMANTITL 2 CCR4-NOT COMPLEXREF NAT.STRUCT.MOL.BIOL. V. 20 1289 2013REFN ISSN 1545-9993PMID 24121232DOI 10.1038/NSMB.2681 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4fo0 ACTR8 human actin-related protein arp8 in its atp-bound state 2.6Å AUTH C.B.GERHOLD,D.D.WINKLER,K.LAKOMEK,F.U.SEIFERT,S.FENN,AUTH 2 B.KESSLER,G.WITTE,K.LUGER,K.P.HOPFNERTITL STRUCTURE OF ACTIN-RELATED PROTEIN 8 AND ITS CONTRIBUTION TOTITL 2 NUCLEOSOME BINDING.REF NUCLEIC ACIDS RES. V. 40 11036 2012REFN ISSN 0305-1048PMID 22977180DOI 10.1093/NAR/GKS842 Variant Set Distributions Mapped Variants
General Structure Information 4b86 MSL2 crystal structure of the msl1-msl2 complex (3.5a) 3.5Å AUTH E.HALLACLI,M.LIPP,P.GEORGIEV,C.SPIELMAN,S.CUSACK,A.AKHTAR,AUTH 2 J.KADLECTITL MSL1-MEDIATED DIMERIZATION OF THE DOSAGE COMPENSATIONTITL 2 COMPLEX IS ESSENTIAL FOR MALE X-CHROMOSOME REGULATION INTITL 3 DROSOPHILA.REF MOL.CELL V. 48 587 2012REFN ISSN 1097-2765PMID 23084835DOI 10.1016/J.MOLCEL.2012.09.014 Variant Set Distributions Mapped Variants
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dl6 CHD8 solution structure of the first brk domain from human chromodomain-helicase-dna-binding protein 8 -1.0Å AUTH T.SUETAKE,T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST BRK DOMAIN FROMTITL 2 HUMAN CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 8REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3q2e BRWD1 crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (wdr9) 1.74Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants