Assessment of Structural Intolerance and Durability
General Structure Information 2khx DROSHA drosha double-stranded rna binding motif -1.0Å AUTH G.A.MUELLER,M.T.MILLER,E.F.DEROSE,M.GHOSH,R.E.LONDON,AUTH 2 T.M.HALLTITL SOLUTION STRUCTURE OF THE DROSHA DOUBLE-STRANDED RNA-BINDINGTITL 2 DOMAIN.REF SILENCE V. 1 2 2010REFN ESSN 1758-907XPMID 20226070DOI 10.1186/1758-907X-1-2 Variant Set Distributions Mapped Variants
General Structure Information 2cpd A1CF solution structure of the rna recognition motif of human apobec-1 complementation factor, acf -1.0Å AUTH T.NAGATA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OFTITL 2 HUMAN APOBEC-1 COMPLEMENTATION FACTOR, ACFREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2m0c ALX4 solution nmr structure of homeobox domain of human alx4, northeast structural genomics consortium (nesg) target hr4490c -1.0Å AUTH X.XU,A.ELETSKY,S.PULAVARTI,D.LEE,H.JANJUA,R.XIAO,T.B.ACTON,AUTH 2 J.K.EVERETT,G.T.MONTELIONE,T.SZYPERSKITITL SOLUTION NMR STRUCTURE OF HOMEOBOX DOMAIN OF HUMAN ALX4,TITL 2 NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGETTITL 3 HR4490CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1d5v FOXC2 solution structure of the forkhead domain of the adipocyte- transcription factor freac-11 (s12) -1.0Å AUTH M.J.VAN DONGEN,A.CEDERBERG,P.CARLSSON,S.ENERBACK,AUTH 2 M.WIKSTROMTITL SOLUTION STRUCTURE AND DYNAMICS OF THE DNA-BINDINGTITL 2 DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTORTITL 3 FREAC-11.REF J.MOL.BIOL. V. 296 351 2000REFN ISSN 0022-2836PMID 10669593DOI 10.1006/JMBI.1999.3476 Variant Set Distributions Mapped Variants
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2cra HOXB13 solution structure of the homeobox domain of human homeo box b13 -1.0Å AUTH K.SEIMIYA,F.HAYASHI,T.NAGASHIMA,M.YOSHIDA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HOMEOBOX DOMAIN OF HUMANTITL 2 HOMEO BOX B13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ell ANP32B solution structure of the leucine rich repeat of human acidic leucine- rich nuclear phosphoprotein 32 family member b -1.0Å AUTH N.TOCHIO,T.UMEHARA,Y.MUNEMASA,T.SUZUKI,S.SATO,K.TSUDA,AUTH 2 S.KOSHIBA,T.KIGAWA,R.NAGAI,S.YOKOYAMATITL SOLUTION STRUCTURE OF HISTONE CHAPERONE ANP32B: INTERACTIONTITL 2 WITH CORE HISTONES H3-H4 THROUGH ITS ACIDIC CONCAVE DOMAIN.REF J.MOL.BIOL. V. 401 97 2010REFN ISSN 0022-2836PMID 20538007DOI 10.1016/J.JMB.2010.06.005 Variant […]
General Structure Information 3c9q WDYHV1 crystal structure of the uncharacterized human protein c8orf32 with bound peptide 1.5Å AUTH E.BITTO,C.A.BINGMAN,J.G.MCCOY,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE UNCHARACTERIZED HUMAN PROTEINTITL 2 C8ORF32 WITH BOUND PEPTIDE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3q0q PUM2 crystal structure of the pumilio-homology domain from human pumilio2 in complex with p38alpha nrea 2.0Å AUTH G.LU,T.M.HALLTITL ALTERNATE MODES OF COGNATE RNA RECOGNITION BY HUMAN PUMILIOTITL 2 PROTEINS.REF STRUCTURE V. 19 361 2011REFN ISSN 0969-2126PMID 21397187DOI 10.1016/J.STR.2010.12.019 Variant Set Distributions Mapped Variants
General Structure Information 4mi0 EZH2 human enhancer of zeste (drosophila) homolog 2(ezh2) 2.0Å AUTH H.WU,H.ZENG,A.DONG,F.LI,H.HE,G.SENISTERRA,A.SEITOVA,S.DUAN,AUTH 2 P.J.BROWN,M.VEDADI,C.H.ARROWSMITH,M.SCHAPIRATITL STRUCTURE OF THE CATALYTIC DOMAIN OF EZH2 REVEALSTITL 2 CONFORMATIONAL PLASTICITY IN COFACTOR AND SUBSTRATE BINDINGTITL 3 SITES AND EXPLAINS ONCOGENIC MUTATIONS.REF PLOS ONE V. 8 83737 2013REFN ESSN 1932-6203PMID 24367611DOI 10.1371/JOURNAL.PONE.0083737 Variant Set Distributions Ripley’s K Analysis […]