Assessment of Structural Intolerance and Durability
General Structure Information 4lir NUP35 crystal structure of a nucleoporin 35kda (nup35) from homo sapiens at 2.46 a resolution 2.46Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A NUCLEOPORIN 35KDA (NUP35) FROM HOMOTITL 2 SAPIENS AT 2.46 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]
General Structure Information 3mqp BCL2A1 crystal structure of human bfl-1 in complex with noxa bh3 peptide, northeast structural genomics consortium target hr2930 2.24Å AUTH R.GUAN,R.XIAO,L.ZHAO,T.B.ACTON,C.GELINAS,G.T.MONTELIONETITL CRYSTAL STRUCTURE OF HUMAN BFL-1 IN COMPLEX WITH NOXA BH3TITL 2 PEPTIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dai ATAD2 crystal structure of the bromodomain of the human atad2 1.95Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 4doh IL20RB il20/il201/il20r2 ternary complex 2.8Å AUTH N.J.LOGSDON,A.DESHPANDE,B.D.HARRIS,K.R.RAJASHANKAR,AUTH 2 M.R.WALTERTITL STRUCTURAL BASIS FOR RECEPTOR SHARING AND ACTIVATION BYTITL 2 INTERLEUKIN-20 RECEPTOR-2 (IL-20R2) BINDING CYTOKINES.REF PROC.NATL.ACAD.SCI.USA V. 109 12704 2012REFN ISSN 0027-8424PMID 22802649DOI 10.1073/PNAS.1117551109 Variant Set Distributions Mapped Variants
General Structure Information 4hon KDM4D crystal structure of human jmjd2d/kdm4d in complex with an h3k9me3 peptide and 2-oxoglutarate 1.8Å AUTH S.KRISHNAN,R.C.TRIEVELTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF JMJD2D REVEALSTITL 2 MOLECULAR BASIS FOR SITE-SPECIFIC DEMETHYLATION AMONG JMJD2TITL 3 DEMETHYLASES.REF STRUCTURE V. 21 98 2013REFN ISSN 0969-2126PMID 23219879DOI 10.1016/J.STR.2012.10.018 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1saw FAHD1 x-ray structure of homo sapiens protein flj36880 2.2Å AUTH B.A.MANJASETTY,F.H.NIESEN,H.DELBRUCK,F.GOTZ,AUTH 2 V.SIEVERT,K.BUSSOW,J.BEHLKE,U.HEINEMANNTITL X-RAY STRUCTURE OF FUMARYLACETOACETATE HYDROLASETITL 2 FAMILY MEMBER HOMO SAPIENS FLJ36880.REF BIOL.CHEM. V. 385 935 2004REFN ISSN 1431-6730PMID 15551868DOI 10.1515/BC.2004.122 Variant Set Distributions Mapped Variants
General Structure Information 3t6p BIRC2 iap antagonist-induced conformational change in ciap1 promotes e3 ligase activation via dimerization 1.9Å AUTH E.C.DUEBER,A.J.SCHOEFFLER,A.LINGEL,J.M.ELLIOTT,A.V.FEDOROVA,AUTH 2 A.M.GIANNETTI,K.ZOBEL,B.MAURER,E.VARFOLOMEEV,P.WU,AUTH 3 H.J.WALLWEBER,S.G.HYMOWITZ,K.DESHAYES,D.VUCIC,AUTH 4 W.J.FAIRBROTHERTITL ANTAGONISTS INDUCE A CONFORMATIONAL CHANGE IN CIAP1 THATTITL 2 PROMOTES AUTOUBIQUITINATION.REF SCIENCE V. 334 376 2011REFN ISSN 0036-8075PMID 22021857DOI 10.1126/SCIENCE.1207862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2fbv WRN wrn exonuclease, mn complex 2.4Å AUTH J.J.PERRY,S.M.YANNONE,L.G.HOLDEN,C.HITOMI,AUTH 2 A.ASAITHAMBY,S.HAN,P.K.COOPER,D.J.CHEN,J.A.TAINERTITL WRN EXONUCLEASE STRUCTURE AND MOLECULAR MECHANISMTITL 2 IMPLY AN EDITING ROLE IN DNA END PROCESSING.REF NAT.STRUCT.MOL.BIOL. V. 13 414 2006REFN ISSN 1545-9993PMID 16622405DOI 10.1038/NSMB1088 Variant Set Distributions Mapped Variants
General Structure Information 2q8h PDK1 structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) 2.0Å AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4ole NBR1 crystal structure of a neighbor of brca1 gene 1 (nbr1) from homo sapiens at 2.52 a resolution 2.52Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)TITL CRYSTAL STRUCTURE OF A NEIGHBOR OF BRCA1 GENE 1 (NBR1) FROMTITL 2 HOMO SAPIENS AT 2.52 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped […]