Assessment of Structural Intolerance and Durability
General Structure Information 2rmn TP63 the solution structure of the p63 dna-binding domain -1.0Å AUTH A.ENTHART,J.FURRER,A.DEHNER,H.KESSLERTITL SOLUTION STRUCTURE AND BINDING STUDIES OF THE P63TITL 2 DNA BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2dkp PLEKHA5 solution structure of the ph domain of pleckstrin homology domain-containing protein family a member 5 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF PLECKSTRINTITL 2 HOMOLOGY DOMAIN-CONTAINING PROTEIN FAMILY A MEMBERTITL 3 5 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tfy NAA50 naa50p amino-terminal acetyltransferase bound to substrate peptide fragment and coa 2.75Å AUTH G.LISZCZAK,T.ARNESEN,R.MARMORSTEINTITL STRUCTURE OF A TERNARY NAA50P (NAT5/SAN) N-TERMINALTITL 2 ACETYLTRANSFERASE COMPLEX REVEALS THE MOLECULAR BASIS FORTITL 3 SUBSTRATE-SPECIFIC ACETYLATION.REF J.BIOL.CHEM. V. 286 37002 2011REFN ISSN 0021-9258PMID 21900231DOI 10.1074/JBC.M111.282863 Variant Set Distributions Mapped Variants
General Structure Information 2ra4 CCL13 crystal structure of human monocyte chemoattractant protein 4 (mcp- 4/ccl13) 1.7Å AUTH C.BARINKA,A.PRAHL,J.LUBKOWSKITITL STRUCTURE OF HUMAN MONOCYTE CHEMOATTRACTANT PROTEIN 4TITL 2 (MCP-4/CCL13).REF ACTA CRYSTALLOGR.,SECT.D V. 64 273 2008REFN ISSN 0907-4449PMID 18323622DOI 10.1107/S0907444907066164 Variant Set Distributions Mapped Variants
General Structure Information 2b9e NSUN5 human nsun5 protein 1.65Å AUTH J.R.MIN,H.WU,H.ZENG,P.LOPPNAU,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN NSUN5 PROTEIN INTITL 2 COMPLEX WITH S-ADENOSYL-L-METHIONINEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dlj CNDP1 crystal structure of human carnosine dipeptidase 1 2.26Å AUTH E.DOBROVETSKY,A.DONG,A.SEITOVA,H.HE,W.TEMPEL,I.KOZIERADZKI,AUTH 2 C.H.ARROWSMITH,J.WEIGELT,C.BOUNTRA,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 D.COSSARTITL CRYSTAL STRUCTURE OF HUMAN CARNOSINE DIPEPTIDASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4m6r APIP structural and biochemical basis for the inhibition of cell death by apip, a methionine salvage enzyme 2.0Å AUTH W.KANG,S.H.HONG,H.M.LEE,N.Y.KIM,Y.C.LIM,L.T.M.LE,B.LIM,AUTH 2 H.C.KIM,T.Y.KIM,H.ASHIDA,A.YOKOTA,S.S.HAH,K.H.CHUN,Y.K.JUNG,AUTH 3 J.K.YANGTITL STRUCTURAL AND BIOCHEMICAL BASIS FOR THE INHIBITION OF CELLTITL 2 DEATH BY APIP, A METHIONINE SALVAGE ENZYME.REF PROC.NATL.ACAD.SCI.USA V. 111 581 2014REFN ISSN 0027-8424PMID 24367089DOI 10.1073/PNAS.1308768111 Variant […]
General Structure Information 3mxo PGAM5 crystal structure oh human phosphoglycerate mutase family member 5 (pgam5) 1.7Å AUTH A.CHAIKUAD,I.ALFANO,S.PICAUD,P.FILIPPAKOPOULOS,A.BARR,AUTH 2 F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 K.TAKEDA,H.ICHIJO,S.KNAPPTITL CRYSTAL STRUCTURE OH HUMAN PHOSPHOGLYCERATE MUTASE FAMILYTITL 2 MEMBER 5 (PGAM5)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1uit DLG5 solution structure of rsgi ruh-006, the third pdz domain of hdlg5 (kiaa0583) protein [homo sapiens] -1.0Å AUTH T.ABE,H.HIROTA,N.KOBAYASHI,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-006, THE THIRD PDZTITL 2 DOMAIN OF HDLG5 (KIAA0583) PROTEIN [HOMO SAPIENS]REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3nr1 HDDC3 a metazoan ortholog of spot hydrolyzes ppgpp and plays a role in starvation responses 1.9Å AUTH D.W.SUN,G.LEE,J.H.LEE,H.Y.KIM,H.W.RHEE,S.Y.PARK,K.J.KIM,AUTH 2 Y.KIM,B.Y.KIM,J.I.HONG,C.PARK,H.E.CHOY,J.H.KIM,Y.H.JEON,AUTH 3 J.CHUNGTITL A METAZOAN ORTHOLOG OF SPOT HYDROLYZES PPGPP AND FUNCTIONSTITL 2 IN STARVATION RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 17 1188 2010REFN ISSN 1545-9993PMID 20818390DOI 10.1038/NSMB.1906 Variant Set Distributions Mapped Variants