General Structure Information
| PDB ID | 4m6r |
| HGNC Gene Label(s) | APIP |
| Structure Name | structural and biochemical basis for the inhibition of cell death by apip, a methionine salvage enzyme |
| Resolution | 2.0Å |
| Reference | AUTH W.KANG,S.H.HONG,H.M.LEE,N.Y.KIM,Y.C.LIM,L.T.M.LE,B.LIM,AUTH 2 H.C.KIM,T.Y.KIM,H.ASHIDA,A.YOKOTA,S.S.HAH,K.H.CHUN,Y.K.JUNG,AUTH 3 J.K.YANGTITL STRUCTURAL AND BIOCHEMICAL BASIS FOR THE INHIBITION OF CELLTITL 2 DEATH BY APIP, A METHIONINE SALVAGE ENZYME.REF PROC.NATL.ACAD.SCI.USA V. 111 581 2014REFN ISSN 0027-8424PMID 24367089DOI 10.1073/PNAS.1308768111 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 223 |
| Number Of SNVs | 52 |
| Number Of Permutations | 27221 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.464 |
| p-value | 0.336 |
COSMIC
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.67 |
| p-value | 0.069 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
