Assessment of Structural Intolerance and Durability
General Structure Information 2doa ELL solution structure of the helical domain in human eleven- nineteen lysine-rich leukemia protein ell -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE HELICAL DOMAIN IN HUMANTITL 2 ELEVEN-NINETEEN LYSINE-RICH LEUKEMIA PROTEIN ELLREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2iu1 EIF5 crystal structure of eif5 c-terminal domain 1.8Å AUTH C.BIENIOSSEK,P.SCHUTZ,M.BUMANN,A.LIMACHER,I.USON,AUTH 2 U.BAUMANNTITL THE CRYSTAL STRUCTURE OF THE CARBOXY-TERMINALTITL 2 DOMAIN OF HUMAN TRANSLATION INITIATION FACTORTITL 3 EIF5.REF J.MOL.BIOL. V. 360 457 2006REFN ISSN 0022-2836PMID 16781736DOI 10.1016/J.JMB.2006.05.021 Variant Set Distributions Mapped Variants
General Structure Information 3bpn IL13RA1 crystal structure of the il4-il4r-il13ra ternary complex 3.02Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Mapped Variants
General Structure Information 2tgi TGFB2 crystal structure of transforming growth factor-beta2: an unusual fold for the superfamily 1.8Å AUTH S.DAOPIN,K.A.PIEZ,Y.OGAWA,D.R.DAVIESTITL CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA 2: ANTITL 2 UNUSUAL FOLD FOR THE SUPERFAMILY.REF SCIENCE V. 257 369 1992REFN ISSN 0036-8075PMID 1631557 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1foe RAC1 crystal structure of rac1 in complex with the guanine nucleotide exchange region of tiam1 2.8Å AUTH D.K.WORTHYLAKE,K.L.ROSSMAN,J.SONDEKTITL CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THETITL 2 GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1.REF NATURE V. 408 682 2000REFN ISSN 0028-0836PMID 11130063DOI 10.1038/35047014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2x7g SRPK2 structure of human serine-arginine-rich protein-specific kinase 2 (srpk2) bound to purvalanol b 2.5Å AUTH A.C.W.PIKE,P.SAVITSKY,O.FEDOROV,T.KROJER,E.UGOCHUKWU,AUTH 2 F.VON DELFT,O.GILEADI,A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN- SPECIFICTITL 2 KINASE 2 (SRPK2) BOUND TO PURVALANOL BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3t6g BCAR1 structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 2d9b GTF2I solution structure of rsgi ruh-052, a gtf2i domain in human cdna -1.0Å AUTH Y.DOI-KATAYAMA,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RSGI RUH-052, A GTF2I DOMAINTITL 2 IN HUMAN CDNAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gl8 RXRG human retinoic acid receptor rxr-gamma ligand-binding domain 2.4Å AUTH A.SCHUETZ,J.R.MIN,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN RETINOIC ACID RECEPTORTITL 2 RXR-GAMMA LIGAND-BINDING DOMAIN.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2dm1 VAV2 solution structure of the second sh3 domain of human protein vav-2 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN PROTEIN VAV-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants