Assessment of Structural Intolerance and Durability
General Structure Information 3dpe MMP8 crystal structure of the complex between mmp-8 and a non- zinc chelating inhibitor 1.6Å AUTH G.POCHETTI,R.MONTANARI,C.GEGE,C.CHEVRIER,AUTH 2 A.G.TAVERAS,F.MAZZATITL EXTRA BINDING REGION INDUCED BY NON-ZINC CHELATINGTITL 2 INHIBITORS INTO THE S(1) SUBSITE OF MATRIXTITL 3 METALLOPROTEINASE 8 (MMP-8)REF J.MED.CHEM. V. 52 1040 2009REFN ISSN 0022-2623PMID 19173605DOI 10.1021/JM801166J Variant Set Distributions Ripley’s […]
General Structure Information 1uuh CD44 hyaluronan binding domain of human cd44 2.2Å AUTH P.TERIETE,S.BANERJI,M.NOBLE,C.BLUNDELL,A.WRIGHT,AUTH 2 A.PICKFORD,E.LOWE,D.MAHONEY,M.TAMMI,J.KAHMANN,AUTH 3 I.CAMPBELL,A.DAY,D.JACKSONTITL STRUCTURE OF THE REGULATORY HYALURONAN-BINDINGTITL 2 DOMAIN IN THE INFLAMMATORY LEUKOCYTE HOMINGTITL 3 RECEPTOR CD44REF MOL.CELL V. 13 483 2004REFN ISSN 1097-2765PMID 14992719DOI 10.1016/S1097-2765(04)00080-2 Variant Set Distributions Mapped Variants
General Structure Information 2knt COL6A3 the 1.2 angstrom structure of kunitz type domain c5 1.2Å AUTH K.MERIGEAU,B.ARNOUX,D.PERAHIA,K.NORRIS,F.NORRIS,AUTH 2 A.DUCRUIXTITL 1.2 A REFINEMENT OF THE KUNITZ-TYPE DOMAIN FROMTITL 2 THE ALPHA3 CHAIN OF HUMAN TYPE VI COLLAGEN.REF ACTA CRYSTALLOGR.,SECT.D V. 54 306 1998REFN ISSN 0907-4449PMID 9761897DOI 10.1107/S0907444997010846 Variant Set Distributions Mapped Variants
General Structure Information 1ux6 THBS1 structure of a thrombospondin c-terminal fragment reveals a novel calcium core in the type 3 repeats 1.9Å AUTH M.KVANSAKUL,J.C.ADAMS,E.HOHENESTERTITL STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENTTITL 2 REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATSREF EMBO J. V. 23 1223 2004REFN ISSN 0261-4189PMID 15014436DOI 10.1038/SJ.EMBOJ.7600166 Variant Set Distributions Ripley’s […]
General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1gxd MMP2 prommp-2/timp-2 complex 3.1Å AUTH E.MORGUNOVA,A.TUUTTILA,U.BERGMANN,K.TRYGGVASONTITL STRUCTURAL INSIGHT INTO THE COMPLEX FORMATION OF LATENTTITL 2 MATRIX METALLOPROTEINASE 2 WITH TISSUE INHIBITOR OFTITL 3 METALLOPROTEINASE 2REF PROC.NATL.ACAD.SCI.USA V. 99 7414 2002REFN ISSN 0027-8424PMID 12032297DOI 10.1073/PNAS.102185399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3m7p FN1 fibronectin fragment 2.5Å AUTH M.GRAILLE,M.PAGANO,T.ROSE,M.REBOUD RAVAUX,H.VAN TILBEURGHTITL ZINC INDUCES STRUCTURAL REORGANIZATION OF GELATIN BINDINGTITL 2 DOMAIN FROM HUMAN FIBRONECTIN AND AFFECTS COLLAGEN BINDINGREF STRUCTURE V. 18 710 2010REFN ISSN 0969-2126PMID 20541508DOI 10.1016/J.STR.2010.03.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fnf FN1 fragment of human fibronectin encompassing type-iii repeats 7 through 10 2.0Å AUTH D.J.LEAHY,I.AUKHIL,H.P.ERICKSONTITL 2.0 A CRYSTAL STRUCTURE OF A FOUR-DOMAIN SEGMENTTITL 2 OF HUMAN FIBRONECTIN ENCOMPASSING THE RGD LOOP ANDTITL 3 SYNERGY REGION.REF CELL(CAMBRIDGE,MASS.) V. 84 155 1996REFN ISSN 0092-8674PMID 8548820DOI 10.1016/S0092-8674(00)81002-8 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2rjp ADAMTS4 crystal structure of adamts4 with inhibitor bound 2.8Å AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,AUTH 2 T.MCDONAGH,S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,AUTH 3 E.L.REIFENBERG,L.A.COLLINS-RACIE,C.CORCORAN,AUTH 4 B.FREEMAN,R.ZOLLNER,T.MARVELL,M.VERA,P.E.SUM,AUTH 5 E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECANTITL 2 DEGRADING ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]