Assessment of Structural Intolerance and Durability
General Structure Information 1y6l UBE2E2 human ubiquitin conjugating enzyme e2e2 1.85Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4fp9 NSUN4 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 2edi UBE2F solution structure of the uq_con domain from human nedd8- conjugating enzyme nce2 -1.0Å AUTH H.ENDO,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE UQ_CON DOMAIN FROM HUMANTITL 2 NEDD8-CONJUGATING ENZYME NCE2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fp9 MTERFD2 human mterf4-nsun4 protein complex 2.9Å AUTH H.SPAHR,B.HABERMANN,C.M.GUSTAFSSON,N.G.LARSSON,B.M.HALLBERGTITL STRUCTURE OF THE HUMAN MTERF4-NSUN4 PROTEIN COMPLEX THATTITL 2 REGULATES MITOCHONDRIAL RIBOSOME BIOGENESIS.REF PROC.NATL.ACAD.SCI.USA V. 109 15253 2012REFN ISSN 0027-8424PMID 22949673DOI 10.1073/PNAS.1210688109 Variant Set Distributions Mapped Variants
General Structure Information 1zdn UBE2S ubiquitin-conjugating enzyme e2s 1.93Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4osy ASRGL1 structure of fully-cleaved glycine-bound human l-asparaginase protein 1.91Å AUTH Y.SU,C.S.KARAMITROS,J.NOMME,T.MCSORLEY,M.KONRAD,A.LAVIETITL FREE GLYCINE ACCELERATES THE AUTOPROTEOLYTIC ACTIVATION OFTITL 2 HUMAN ASPARAGINASE.REF CHEM.BIOL. V. 20 533 2013REFN ISSN 1074-5521PMID 23601642DOI 10.1016/J.CHEMBIOL.2013.03.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1w7n CCBL1 crystal structure of human kynurenine aminotransferase i in pmp form 2.9Å AUTH F.ROSSI,Q.HAN,J.LI,J.LI,M.RIZZITITL CRYSTAL STRUCTURE OF HUMAN KYNURENINETITL 2 AMINOTRANSFERASE IREF J.BIOL.CHEM. V. 279 50214 2004REFN ISSN 0021-9258PMID 15364907DOI 10.1074/JBC.M409291200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1yrv UBE2U novel ubiquitin-conjugating enzyme 2.18Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3dbr NAE1 structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8s e1 (appbp1- uba3arg190gln-nedd8ala72arg) 3.05Å AUTH J.SOUPHRON,M.B.WADDELL,A.PAYDAR,Z.TOKGOZ-GROMLEY,AUTH 2 M.F.ROUSSEL,B.A.SCHULMANTITL STRUCTURAL DISSECTION OF A GATING MECHANISMTITL 2 PREVENTING MISACTIVATION OF UBIQUITIN BY NEDD8STITL 3 E1.REF BIOCHEMISTRY V. 47 8961 2008REFN ISSN 0006-2960PMID 18652489DOI 10.1021/BI800604C Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants