Assessment of Structural Intolerance and Durability
General Structure Information 2ekf AUP1 solution structure of ruh-075, a human cue domain -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RUH-075, A HUMAN CUE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4ael PDE10A pde10a in complex with the inhibitor az5 2.2Å AUTH U.BAUER,F.GIORDANETTO,M.BAUER,G.OMAHONY,K.E.JOHANSSON,AUTH 2 W.KNECHT,J.HARTLEIB-GESCHWINDNER,E.T.CARLSSON,C.ENROTHTITL DISCOVERY OF 4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILETITL 2 DERIVATIVES AS NOVEL PDE10A INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 1944 2012REFN ISSN 0960-894XPMID 22321214DOI 10.1016/J.BMCL.2012.01.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mdv CYP46A1 clotrimazole complex of cytochrome p450 46a1 2.4Å AUTH N.MAST,C.CHARVET,I.A.PIKULEVA,C.D.STOUTTITL STRUCTURAL BASIS OF DRUG BINDING TO CYP46A1, AN ENZYME THATTITL 2 CONTROLS CHOLESTEROL TURNOVER IN THE BRAIN.REF J.BIOL.CHEM. V. 285 31783 2010REFN ISSN 0021-9258PMID 20667828DOI 10.1074/JBC.M110.143313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t9l USP15 structure of n-terminal dusp-ubl domains of human usp15 1.5Å AUTH S.HARPER,T.M.BESONG,J.EMSLEY,D.J.SCOTT,I.DREVENYTITL STRUCTURE OF THE USP15 N-TERMINAL DOMAINS: A BETA-HAIRPINTITL 2 MEDIATES CLOSE ASSOCIATION BETWEEN THE DUSP AND UBL DOMAINSREF BIOCHEMISTRY V. 50 7995 2011REFN ISSN 0006-2960PMID 21848306DOI 10.1021/BI200726E Variant Set Distributions Mapped Variants
General Structure Information 1y8r UBA2 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1y8r SAE1 sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex 2.75Å AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 Variant Set Distributions Mapped Variants
General Structure Information 3zrh ZRANB1 crystal structure of the lys29, lys33-linkage-specific trabid otu deubiquitinase domain reveals an ankyrin-repeat ubiquitin binding domain (ankubd) 2.23Å AUTH J.D.F.LICCHESI,J.MIESZCZANEK,T.E.T.MEVISSEN,T.J.RUTHERFORD,AUTH 2 M.AKUTSU,S.VIRDEE,F.E.OUALID,J.W.CHIN,H.OVAA,M.BIENZ,AUTH 3 D.KOMANDERTITL AN ANKYRIN-REPEAT UBIQUITIN-BINDING DOMAIN DETERMINESTITL 2 TRABIDS SPECIFICITY FOR ATYPICAL UBIQUITIN CHAINS.REF NAT.STRUCT.MOL.BIOL. V. 19 62 2011REFN ISSN 1545-9993PMID 22157957DOI 10.1038/NSMB.2169 Variant Set Distributions Ripley’s K […]
General Structure Information 1whl CYLD solution structure of the 1st cap-gly domain in human cylindromatosis tumor suppressor cyld -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST CAP-GLY DOMAIN INTITL 2 HUMAN CYLINDROMATOSIS TUMOR SUPPRESSOR CYLDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2vhf CYLD structure of the cyld usp domain 2.8Å AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]