Assessment of Structural Intolerance and Durability
General Structure Information 1whm CYLD solution structure of the 2nd cap-gly domain in human cylindromatosis tumor suppressor cyld -1.0Å AUTH K.SAITOK,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 2ND CAP-GLY DOMAIN INTITL 2 HUMAN CYLINDROMATOSIS TUMOR SUPPRESSOR CYLDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dpz HRASLS2 crystal structure of human hrasls2 1.25Å AUTH M.GOLCZAK,P.D.KISER,A.E.SEARS,D.T.LODOWSKI,W.S.BLANER,AUTH 2 K.PALCZEWSKITITL STRUCTURAL BASIS FOR THE ACYLTRANSFERASE ACTIVITY OFTITL 2 LECITHIN:RETINOL ACYLTRANSFERASE-LIKE PROTEINS.REF J.BIOL.CHEM. V. 287 23790 2012REFN ISSN 0021-9258PMID 22605381DOI 10.1074/JBC.M112.361550 Variant Set Distributions Mapped Variants
General Structure Information 2ejm MCCC1 solution structure of ruh-072, an apo-biotnyl domain form human acetyl coenzyme a carboxylase -1.0Å AUTH A.Z.M.RUHUL MOMEN,H.HIROTA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF RUH-072, AN APO-BIOTNYLTITL 2 DOMAIN FORM HUMAN ACETYL COENZYME A CARBOXYLASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1nut NMNAT3 crystal structure of human cytosolic nmn/namn adenylyltransferase complexed with atp analog 1.9Å AUTH X.ZHANG,O.V.KURNASOV,S.KARTHIKEYAN,N.V.GRISHIN,A.L.OSTERMAN,AUTH 2 H.ZHANGTITL STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NAMNTITL 2 ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NADTITL 3 BIOSYNTHESISREF J.BIOL.CHEM. V. 278 13503 2003REFN ISSN 0021-9258PMID 12574164DOI 10.1074/JBC.M300073200 Variant Set Distributions Mapped Variants
General Structure Information 2jam CAMK1G crystal structure of human calmodulin-dependent protein kinase i g 1.7Å AUTH J.E.DEBRECZENI,A.BULLOCK,T.KEATES,F.H.NIESEN,AUTH 2 E.SALAH,L.SHRESTHA,C.SMEE,F.SOBOTT,A.C.W.PIKE,AUTH 3 G.BUNKOCZI,F.VON DELFT,A.TURNBULL,J.WEIGELT,AUTH 4 C.H.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE I GREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tht ALKBH8 crystal structure and rna binding properties of the rrm/alkb domains in human abh8, an enzyme catalyzing trna hypermodification, northeast structural genomics consortium target hr5601b 3.01Å AUTH C.PASTORE,I.TOPALIDOU,F.FOROUHAR,A.C.YAN,M.LEVY,J.F.HUNTTITL CRYSTAL STRUCTURE AND RNA BINDING PROPERTIES OF THE RNATITL 2 RECOGNITION MOTIF (RRM) AND ALKB DOMAINS IN HUMAN ALKBTITL 3 HOMOLOG 8 (ABH8), […]
General Structure Information 3bl7 DCPS synthetic gene encoded dcps bound to inhibitor dg156844 2.31Å AUTH J.SINGH,M.SALCIUS,S.W.LIU,B.L.STAKER,R.MISHRA,AUTH 2 J.THURMOND,G.MICHAUD,D.R.MATTOON,J.PRINTEN,AUTH 3 J.CHRISTENSEN,J.M.BJORNSSON,B.A.POLLOK,M.KILEDJIAN,AUTH 4 L.STEWART,J.JARECKI,M.E.GURNEYTITL DCPS AS A THERAPEUTIC TARGET FOR SPINAL MUSCULARTITL 2 ATROPHY.REF ACS CHEM.BIOL. V. 3 711 2008REFN ISSN 1554-8929PMID 18839960DOI 10.1021/CB800120T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2rkb SDSL serine dehydratase like-1 from human cancer cells 2.8Å AUTH T.YAMADA,J.KOMOTO,T.KASUYA,Y.TAKATA,H.OGAWA,H.MORI,AUTH 2 F.TAKUSAGAWATITL A CATALYTIC MECHANISM THAT EXPLAINS A LOW CATALYTIC ACTIVITYTITL 2 OF SERINE DEHYDRATASE LIKE-1 FROM HUMAN CANCER CELLS:TITL 3 CRYSTAL STRUCTURE AND SITE-DIRECTED MUTAGENESIS STUDIES.REF BIOCHIM.BIOPHYS.ACTA V.1780 809 2008REFN ISSN 0006-3002PMID 18342636DOI 10.1016/J.BBAGEN.2008.01.020 Variant Set Distributions Ripley’s K […]
General Structure Information 2a7l UBE2W structure of the human hypothetical ubiquitin-conjugating enzyme, loc55284 1.82Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 2f1z USP7 crystal structure of hausp 3.2Å AUTH M.HU,L.GU,M.LI,P.D.JEFFREY,W.GU,Y.SHITITL STRUCTURAL BASIS OF COMPETITIVE RECOGNITION OF P53TITL 2 AND MDM2 BY HAUSP/USP7: IMPLICATIONS FOR THETITL 3 REGULATION OF THE P53-MDM2 PATHWAY.REF PLOS BIOL. V. 4 E27 2006REFN ISSN 1544-9173PMID 16402859DOI 10.1371/JOURNAL.PBIO.0040027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants