Assessment of Structural Intolerance and Durability
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 4c0a IQSEC1 arf1(delta1-17)in complex with brag2 sec7-ph domain 3.3Å AUTH K.AIZEL,V.BIOU,J.NAVAZA,L.V.DUARTE,V.CAMPANACCI,J.CHERFILS,AUTH 2 M.ZEGHOUFTITL INTEGRATED CONFORMATIONAL AND LIPID-SENSING REGULATION OFTITL 2 ENDOSOMAL ARFGEF BRAG2.REF PLOS BIOL. V. 11 01652 2013REFN ISSN 1544-9173PMID 24058294DOI 10.1371/JOURNAL.PBIO.1001652 Variant Set Distributions Mapped Variants
General Structure Information 3qbv ITSN1 structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin 2.65Å AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2khn ITSN1 nmr solution structure of the eh 1 domain from human intersectin-1 protein. northeast structural genomics consortium target hr3646e. -1.0Å AUTH J.L.MILLS,A.GHOSH,E.GARCIA,Q.ZHANG,R.SHASTRY,AUTH 2 E.L.FOOTE,H.JANJUA,T.B.ACTON,R.XIAO,J.K.EVERETT,AUTH 3 G.T.MONTELIONE,T.SZYPERSKITITL NMR SOLUTION STRUCTURE OF THE EH 1 DOMAIN FROMTITL 2 HUMAN INTERSECTIN-1 PROTEIN. NORTHEAST STRUCTURALTITL 3 GENOMICS CONSORTIUM TARGET HR3646E.REF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2qy7 CLINT1 crystal structure of human epsinr enth domain 2.0Å AUTH S.E.MILLER,B.M.COLLINS,A.J.MCCOY,M.S.ROBINSON,AUTH 2 D.J.OWENTITL A SNARE-ADAPTOR INTERACTION IS A NEW MODE OF CARGOTITL 2 RECOGNITION IN CLATHRIN-COATED VESICLES.REF NATURE V. 450 570 2007REFN ISSN 0028-0836PMID 18033301DOI 10.1038/NATURE06353 Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2ke4 TRIP10 the nmr structure of the tc10 and cdc42 interacting domain of cip4 -1.0Å AUTH Y.KOBASHIGAWA,H.KUMETA,D.KANOH,F.INAGAKITITL THE NMR STRUCTURE OF THE TC10- ANDTITL 2 CDC42-INTERACTING DOMAIN OF CIP4.REF J.BIOMOL.NMR V. 44 113 2009REFN ISSN 0925-2738PMID 19387844DOI 10.1007/S10858-009-9317-Z Variant Set Distributions Mapped Variants
General Structure Information 2qv2 OCRL a role of the lowe syndrome protein ocrl in early steps of the endocytic pathway 2.4Å AUTH K.S.ERDMANN,Y.MAO,H.J.MCCREA,R.ZONCU,S.LEE,AUTH 2 S.PARADISE,J.MODREGGER,D.BIEMESDERFER,D.TOOMRE,AUTH 3 P.DE CAMILLITITL A ROLE OF THE LOWE SYNDROME PROTEIN OCRL IN EARLYTITL 2 STEPS OF THE ENDOCYTIC PATHWAYREF DEV.CELL V. 13 377 2007REFN ISSN 1534-5807PMID 17765681DOI 10.1016/J.DEVCEL.2007.08.004 Variant Set […]
General Structure Information 2qv2 OCRL a role of the lowe syndrome protein ocrl in early steps of the endocytic pathway 2.4Å AUTH K.S.ERDMANN,Y.MAO,H.J.MCCREA,R.ZONCU,S.LEE,AUTH 2 S.PARADISE,J.MODREGGER,D.BIEMESDERFER,D.TOOMRE,AUTH 3 P.DE CAMILLITITL A ROLE OF THE LOWE SYNDROME PROTEIN OCRL IN EARLYTITL 2 STEPS OF THE ENDOCYTIC PATHWAYREF DEV.CELL V. 13 377 2007REFN ISSN 1534-5807PMID 17765681DOI 10.1016/J.DEVCEL.2007.08.004 Variant Set […]
General Structure Information 2qv2 OCRL a role of the lowe syndrome protein ocrl in early steps of the endocytic pathway 2.4Å AUTH K.S.ERDMANN,Y.MAO,H.J.MCCREA,R.ZONCU,S.LEE,AUTH 2 S.PARADISE,J.MODREGGER,D.BIEMESDERFER,D.TOOMRE,AUTH 3 P.DE CAMILLITITL A ROLE OF THE LOWE SYNDROME PROTEIN OCRL IN EARLYTITL 2 STEPS OF THE ENDOCYTIC PATHWAYREF DEV.CELL V. 13 377 2007REFN ISSN 1534-5807PMID 17765681DOI 10.1016/J.DEVCEL.2007.08.004 Variant Set […]