Assessment of Structural Intolerance and Durability
General Structure Information 3g5c ADAM22 structural and biochemical studies on the ectodomain of human adam22 2.36Å AUTH H.LIU,A.SHIM,X.CHEN,X.HETITL STRUCTURAL AND BIOCHEMICAL STUDIES ON THE ECTODOMAIN OFTITL 2 HUMAN ADAM22REF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jtc PROCR importance of mg2+ in the ca2+-dependent folding of the gamma- carboxyglutamic acid domains of vitamin k-dependent clotting and anticlotting proteins 1.6Å AUTH K.VADIVEL,S.AGAH,A.S.MESSER,D.CASCIO,M.S.BAJAJ,AUTH 2 S.KRISHNASWAMY,C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL STRUCTURAL AND FUNCTIONAL STUDIES OF GAMMA-CARBOXYGLUTAMICTITL 2 ACID DOMAINS OF FACTOR VIIA AND ACTIVATED PROTEIN C: ROLE OFTITL 3 MAGNESIUM AT PHYSIOLOGICAL CALCIUM.REF J.MOL.BIOL. V. […]
General Structure Information 2box EMR2 egf domains 1,2,5 of human emr2, a 7-tm immune system molecule, in complex with strontium. 2.5Å AUTH R.J.M.ABBOTT,I.SPENDLOVE,P.ROVERSI,H.FITZGIBBON,V.KNOTT,AUTH 2 P.TERIETE,J.M.MCDONNELL,P.A.HANDFORD,S.M.LEATITL STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A NOVEL TTITL 2 CELL RECEPTOR CO-REGULATORY PROTEIN COMPLEX, CD97-CD55.REF J.BIOL.CHEM. V. 282 22023 2007REFN ISSN 0021-9258PMID 17449467DOI 10.1074/JBC.M702588200 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3h5c SERPINA10 x-ray structure of protein z-protein z inhibitor complex 3.26Å AUTH X.HUANG,A.DEMENTIEV,S.T.OLSON,P.G.GETTINSTITL BASIS FOR THE SPECIFICITY AND ACTIVATION OF THE SERPINTITL 2 PROTEIN Z-DEPENDENT PROTEINASE INHIBITOR (ZPI) AS ANTITL 3 INHIBITOR OF MEMBRANE-ASSOCIATED FACTOR XA.REF J.BIOL.CHEM. V. 285 20399 2010REFN ISSN 0021-9258PMID 20427285DOI 10.1074/JBC.M110.112748 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2wft HHIP crystal structure of the human hip ectodomain 2.8Å AUTH B.BISHOP,A.R.ARICESCU,K.HARLOS,C.A.OCALLAGHAN,AUTH 2 E.Y.JONES,C.SIEBOLDTITL STRUCTURAL INSIGHTS INTO HEDGEHOG LIGANDTITL 2 SEQUESTRATION BY THE HUMAN HEDGEHOG-INTERACTINGTITL 3 PROTEIN HIPREF NAT.STRUCT.MOL.BIOL. V. 16 698 2009REFN ISSN 1545-9993PMID 19561611DOI 10.1038/NSMB.1607 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gcw PCSK9 pcsk9:egfa(h306y) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gcx PCSK9 pcsk9:egfa (ph 7.4) 2.7Å AUTH M.C.MCNUTT,H.J.KWON,C.CHEN,J.R.CHEN,J.D.HORTON,T.A.LAGACETITL ANTAGONISM OF SECRETED PCSK9 INCREASES LOW DENSITYTITL 2 LIPOPROTEIN RECEPTOR EXPRESSION IN HEPG2 CELLS.REF J.BIOL.CHEM. V. 284 10561 2009REFN ISSN 0021-9258PMID 19224862DOI 10.1074/JBC.M808802200 Variant Set Distributions Mapped Variants
General Structure Information 2c5d GAS6 structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pe4 HYAL1 structure of human hyaluronidase 1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis 2.0Å AUTH K.L.CHAO,L.MUTHUKUMAR,O.HERZBERGTITL STRUCTURE OF HUMAN HYALURONIDASE-1, A HYALURONAN HYDROLYZINGTITL 2 ENZYME INVOLVED IN TUMOR GROWTH AND ANGIOGENESISREF BIOCHEMISTRY V. 46 6911 2007REFN ISSN 0006-2960PMID 17503783DOI 10.1021/BI700382G Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4cc1 JAG1 notch ligand, jagged-1, contains an n-terminal c2 domain 2.84Å AUTH C.R.CHILAKURI,D.SHEPPARD,M.X.G.ILAGAN,L.R.HOLT,F.ABBOTT,AUTH 2 S.LIANG,R.KOPAN,P.A.HANDFORD,S.M.LEATITL STRUCTURAL ANALYSIS UNCOVERS LIPID-BINDING PROPERTIES OFTITL 2 NOTCH LIGANDSREF CELL REP. V. 5 861 2013REFN ISSN 2211-1247PMID 24239355DOI 10.1016/J.CELREP.2013.10.029 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants