General Structure Information
| PDB ID | 4cc1 |
| HGNC Gene Label(s) | JAG1 |
| Structure Name | notch ligand, jagged-1, contains an n-terminal c2 domain |
| Resolution | 2.84Å |
| Reference | AUTH C.R.CHILAKURI,D.SHEPPARD,M.X.G.ILAGAN,L.R.HOLT,F.ABBOTT,AUTH 2 S.LIANG,R.KOPAN,P.A.HANDFORD,S.M.LEATITL STRUCTURAL ANALYSIS UNCOVERS LIPID-BINDING PROPERTIES OFTITL 2 NOTCH LIGANDSREF CELL REP. V. 5 861 2013REFN ISSN 2211-1247PMID 24239355DOI 10.1016/J.CELREP.2013.10.029 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 304 |
| Number Of SNVs | 38 |
| Number Of Permutations | 24812 |
| Optimal Distance Threshold | 42.0 |
| K Statistic | 0.535 |
| p-value | 0.341 |
ClinVar
| Number Of Residues | 304 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1779 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.852 |
COSMIC
| Number Of Residues | 304 |
| Number Of SNVs | 3 |
| Number Of Permutations | 81 |
| Optimal Distance Threshold | 39.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.127 |
| p-value | 0.727 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | -0.394 |
| p-value | 0.974 |