Assessment of Structural Intolerance and Durability
General Structure Information 1urf PKN1 hr1b domain from prk1 -1.0Å AUTH D.OWEN,P.N.LOWE,D.NIETLISPACH,C.E.BROSNAN,AUTH 2 D.Y.CHIRGADZE,P.J.PARKER,T.L.BLUNDELL,H.R.MOTTTITL MOLECULAR DISSECTION OF THE INTERACTION BETWEENTITL 2 THE SMALL G PROTEINS RAC1 AND RHOA AND PROTEINTITL 3 KINASE C-RELATED KINASE 1 (PRK1)REF J.BIOL.CHEM. V. 278 50578 2003REFN ISSN 0021-9258PMID 14514689DOI 10.1074/JBC.M304313200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2coc FGD3 solution structure of the c-terminal ph domain of fyve, rhogef and ph domain containing protein 3 (fgd3) from human -1.0Å AUTH H.LI,T.TOMIZAWA,N.TOCHIO,Y.MUTO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C-TERMINAL PH DOMAIN OFTITL 2 FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3TITL 3 (FGD3) FROM HUMANREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 2dno CELF3 solution structure of rna binding domain in trinucleotide repeat containing 4 variant -1.0Å AUTH K.TSUDA,Y.MUTO,M.INOUE,T.KIGAWA,T.TERADA,AUTH 2 M.SHIROUZU,S.YOKOYAMATITL SOLUTION STRUCTURE OF RNA BINDING DOMAIN INTITL 2 TRINUCLEOTIDE REPEAT CONTAINING 4 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2di7 KDELC1 solution structure of the filamin domain from human bk158_1 protein -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FILAMIN DOMAIN FROMTITL 2 HUMAN BK158_1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qbv ITSN1 structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin 2.65Å AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2prg NCOA1 ligand-binding domain of the human peroxisome proliferator activated receptor gamma 2.3Å AUTH R.T.NOLTE,G.B.WISELY,S.WESTIN,J.E.COBB,M.H.LAMBERT,AUTH 2 R.KUROKAWA,M.G.ROSENFELD,T.M.WILLSON,C.K.GLASS,AUTH 3 M.V.MILBURNTITL LIGAND BINDING AND CO-ACTIVATOR ASSEMBLY OF THETITL 2 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA.REF NATURE V. 395 137 1998REFN ISSN 0028-0836PMID 9744270DOI 10.1038/25931 Variant Set Distributions Mapped Variants
General Structure Information 1wis SDK2 solution structure of the fifth fniii domain from human kiaa1514 protein -1.0Å AUTH T.SUETAKE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH FNIII DOMAIN FROMTITL 2 HUMAN KIAA1514 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3o46 MPP7 crystal structure of the pdz domain of mpp7 1.3Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,N.ZHONG,X.GUAN,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF MPP7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rpp MBNL2 solution structure of tandem zinc finger domain 12 in muscleblind-like protein 2 -1.0Å AUTH F.HE,W.DANG,C.ABE,K.TSUDA,M.INOUE,S.WATANABE,AUTH 2 N.KOBAYASHI,T.KIGAWA,T.MATSUDA,T.YABUKI,M.AOKI,AUTH 3 E.SEKI,T.HARADA,Y.TOMABECHI,T.TERADA,M.SHIROUZU,AUTH 4 A.TANAKA,P.GUNTERT,Y.MUTO,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RNA BINDING DOMAIN INTITL 2 THE HUMAN MUSCLEBLIND-LIKE PROTEIN 2REF PROTEIN SCI. V. 18 80 2009REFN ISSN 0961-8368PMID 19177353DOI 10.1002/PRO.17 Variant Set Distributions Mapped Variants