Assessment of Structural Intolerance and Durability
General Structure Information 1v89 ARHGAP25 solution structure of the pleckstrin homology domain of human kiaa0053 protein -1.0Å AUTH H.LI,N.TOCHIO,S.KOSHIBA,M.INOUE,H.HIROTA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGYTITL 2 DOMAIN OF HUMAN KIAA0053 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3be2 KDR crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor 1.75Å AUTH J.C.HARMANGE,M.M.WEISS,J.GERMAIN,A.J.POLVERINO,AUTH 2 G.BORG,J.BREADY,D.CHEN,D.CHOQUETTE,A.COXON,AUTH 3 T.DEMELFI,L.DIPIETRO,N.DOERR,J.ESTRADA,J.FLYNN,AUTH 4 R.F.GRACEFFA,S.P.HARRIMAN,S.KAUFMAN,D.S.LA,A.LONG,AUTH 5 M.W.MARTIN,S.NEERVANNAN,V.F.PATEL,M.POTASHMAN,AUTH 6 K.REGAL,P.M.ROVETO,M.L.SCHRAG,C.STARNES,A.TASKER,AUTH 7 Y.TEFFERA,L.WANG,R.D.WHITE,D.A.WHITTINGTON,R.ZANONTITL NAPHTHAMIDES AS NOVEL AND POTENT VASCULARTITL 2 ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASETITL 3 INHIBITORS: DESIGN, SYNTHESIS, AND EVALUATION.REF J.MED.CHEM. V. 51 […]
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3n3f COL15A1 crystal structure of the human collagen xv trimerization domain: a potent trimerizing unit common to multiplexin collagens 2.0Å AUTH J.A.WIRZ,S.P.BOUDKO,T.F.LERCH,M.S.CHAPMAN,H.P.BACHINGERTITL CRYSTAL STRUCTURE OF THE HUMAN COLLAGEN XV TRIMERIZATIONTITL 2 DOMAIN: A POTENT TRIMERIZING UNIT COMMON TO MULTIPLEXINTITL 3 COLLAGENS.REF MATRIX BIOL. V. 30 9 2011REFN ISSN 0945-053XPMID 20932905DOI 10.1016/J.MATBIO.2010.09.005 Variant […]
General Structure Information 4ekc RGS2 structure of human regulator of g protein signaling 2 (rgs2) in complex with murine galpha-q(r183c) 7.4Å AUTH M.R.NANCE,B.KREUTZ,V.M.TESMER,R.STERNE-MARR,T.KOZASA,AUTH 2 J.J.TESMERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE REGULATOR OF GTITL 2 PROTEIN SIGNALING 2-G ALPHA Q COMPLEX.REF STRUCTURE V. 21 438 2013REFN ISSN 0969-2126PMID 23434405DOI 10.1016/J.STR.2012.12.016 Variant Set Distributions Mapped Variants
General Structure Information 1rjb FLT3 crystal structure of flt3 2.1Å AUTH J.GRIFFITH,J.BLACK,C.FAERMAN,L.SWENSON,M.WYNN,F.LU,AUTH 2 J.LIPPKE,K.SAXENATITL THE STRUCTURAL BASIS FOR AUTOINHIBITION OF FLT3 BYTITL 2 THE JUXTAMEMBRANE DOMAIN.REF MOL.CELL V. 13 169 2004REFN ISSN 1097-2765PMID 14759363DOI 10.1016/S1097-2765(03)00505-7 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l5h IL6ST crystal structure of the full ectodomain of human gp130: new insights into the molecular assembly of receptor complexes 3.6Å AUTH Y.XU,N.KERSHAW,C.S.LUO,P.SOO,M.POCOCK,P.E.CZABOTAR,AUTH 2 D.J.HILTON,N.A.NICOLA,T.P.J.GARRETT,J.G.ZHANGTITL CRYSTAL STRUCTURE OF THE ENTIRE ECTODOMAIN OF GP130:TITL 2 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINETITL 3 RECEPTOR COMPLEXESREF TO BE PUBLISHEDREFN Variant Set Distributions […]
General Structure Information 2c5d AXL structure of a minimal gas6-axl complex 3.3Å AUTH T.SASAKI,P.G.KNYAZEV,N.J.CLOUT,Y.CHEBURKIN,AUTH 2 W.GOEHRING,A.ULLRICH,R.TIMPL,E.HOHENESTERTITL STRUCTURAL BASIS FOR GAS6-AXL SIGNALLING.REF EMBO J. V. 25 80 2006REFN ISSN 0261-4189PMID 16362042DOI 10.1038/SJ.EMBOJ.7600912 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kvq KDR crystal structure of vegfr2 extracellular domain d7 2.7Å AUTH Y.YANG,P.XIE,Y.OPATOWSKY,J.SCHLESSINGERTITL DIRECT CONTACTS BETWEEN EXTRACELLULARTITL 2 MEMBRANE-PROXIMAL DOMAINS ARE REQUIRED FOR VEGFTITL 3 RECEPTOR ACTIVATION AND CELL SIGNALINGREF PROC.NATL.ACAD.SCI.USA V. 107 1906 2010REFN ISSN 0027-8424PMID 20080685DOI 10.1073/PNAS.0914052107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3eac CSK crystal structure of sh2 domain of human csk (carboxyl-terminal src kinase), oxidized form. 1.37Å AUTH D.LIU,R.D.SEIDEL,D.COWBURNTITL OBSERVATION OF DOMAIN INTERACTIONS IN PROTEIN TYROSINETITL 2 KINASE CSK BY SEGMENTAL LABELING NMRREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants