Assessment of Structural Intolerance and Durability
General Structure Information 2jrz KDM5C solution structure of the bright/arid domain from the human jarid1c protein. -1.0Å AUTH C.KOEHLER,S.BISHOP,E.F.DOWLER,P.SCHMIEDER,A.DIEHL,AUTH 2 H.OSCHKINAT,L.J.BALLTITL BACKBONE AND SIDECHAIN 1H, 13C AND 15N RESONANCETITL 2 ASSIGNMENTS OF THE BRIGHT/ARID DOMAIN FROM THETITL 3 HUMAN JARID1C (SMCX) PROTEIN.REF BIOMOL.NMR ASSIGN. V. 2 9 2008REFN ISSN 1874-2718PMID 19636912DOI 10.1007/S12104-007-9071-7 Variant Set Distributions […]
General Structure Information 3nyo GRK6 crystal structure of g protein-coupled receptor kinase 6 in complex with amp 2.92Å AUTH C.A.BOGUTH,P.SINGH,C.C.HUANG,J.J.TESMERTITL MOLECULAR BASIS FOR ACTIVATION OF G PROTEIN-COUPLED RECEPTORTITL 2 KINASES.REF EMBO J. V. 29 3249 2010REFN ISSN 0261-4189PMID 20729810DOI 10.1038/EMBOJ.2010.206 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kg5 CD79B crystal structure of human ig-beta homodimer 3.2Å AUTH S.RADAEV,Z.ZOU,P.TOLAR,K.NGUYEN,A.NGUYEN,P.D.KRUEGER,AUTH 2 N.STUTZMAN,S.PIERCE,P.D.SUNTITL STRUCTURAL AND FUNCTIONAL STUDIES OF IGALPHABETA AND ITSTITL 2 ASSEMBLY WITH THE B CELL ANTIGEN RECEPTOR.REF STRUCTURE V. 18 934 2010REFN ISSN 0969-2126PMID 20696394DOI 10.1016/J.STR.2010.04.019 Variant Set Distributions Mapped Variants
General Structure Information 1yo8 THBS2 structure of the c-terminal domain of human thrombospondin-2 2.6Å AUTH C.B.CARLSON,D.A.BERNSTEIN,D.S.ANNIS,T.M.MISENHEIMER,AUTH 2 B.L.HANNAH,D.F.MOSHER,J.L.KECKTITL STRUCTURE OF THE CALCIUM-RICH SIGNATURE DOMAIN OF HUMANTITL 2 THROMBOSPONDIN-2REF NAT.STRUCT.MOL.BIOL. V. 12 910 2005REFN ISSN 1545-9993PMID 16186819DOI 10.1038/NSMB997 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1x6g MATK solution structures of the sh3 domain of human megakaryocyte-associated tyrosine-protein kinase. -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE SH3 DOMAIN OF HUMANTITL 2 MEGAKARYOCYTE-ASSOCIATED TYROSINE-PROTEIN KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2cbz ABCC1 structure of the human multidrug resistance protein 1 nucleotide binding domain 1 1.5Å AUTH O.RAMAEN,N.LEULLIOT,C.SIZUN,N.ULRYCK,O.PAMLARD,AUTH 2 J.-Y.LALLEMAND,H.VAN TILBEURGH,E.JACQUETTITL STRUCTURE OF THE HUMAN MULTIDRUG RESISTANCETITL 2 PROTEIN 1 NUCLEOTIDE BINDING DOMAIN 1 BOUND TOTITL 3 MG(2+)/ATP REVEALS A NON-PRODUCTIVE CATALYTICTITL 4 SITE.REF J.MOL.BIOL. V. 359 940 2006REFN ISSN 0022-2836PMID 16697012DOI 10.1016/J.JMB.2006.04.005 […]
General Structure Information 2lly CHRNA4 nmr structures of the transmembrane domains of the nachr a4 subunit -1.0Å AUTH V.BONDARENKO,D.MOWREY,T.TILLMAN,T.CUI,L.T.LIU,Y.XU,P.TANGTITL NMR STRUCTURES OF THE TRANSMEMBRANE DOMAINS OF THE A4B2TITL 2 NACHR.REF BIOCHIM.BIOPHYS.ACTA V.1818 1261 2012REFN ISSN 0006-3002PMID 22361591DOI 10.1016/J.BBAMEM.2012.02.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3us4 MATK crystal structure of a sh2 domain of a megakaryocyte-associated tyrosine kinase (matk) from homo sapiens at 1.50 a resolution 1.5Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A SH2 DOMAIN OF ATITL 2 MEGAKARYOCYTE-ASSOCIATED TYROSINE KINASE (MATK) FROM HOMOTITL 3 SAPIENS […]
General Structure Information 3tje FAS crystal structure of fas receptor extracellular domain in complex with fab e09 1.93Å AUTH M.CHODORGE,S.ZUGER,C.STIRNIMANN,C.BRIAND,L.JERMUTUS,AUTH 2 M.G.GRUTTER,R.R.MINTERTITL A SERIES OF FAS RECEPTOR AGONIST ANTIBODIES THAT DEMONSTRATETITL 2 AN INVERSE CORRELATION BETWEEN AFFINITY AND POTENCY.REF CELL DEATH DIFFER. V. 19 1187 2012REFN ISSN 1350-9047PMID 22261618DOI 10.1038/CDD.2011.208 Variant Set Distributions Mapped Variants
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants