Assessment of Structural Intolerance and Durability
General Structure Information 2qc7 ERP29 crystal structure of the protein-disulfide isomerase related chaperone erp29 2.9Å AUTH N.N.BARAK,P.NEUMANN,M.SEVVANA,M.SCHUTKOWSKI,K.NAUMANN,AUTH 2 M.MALESEVIC,H.REICHARDT,G.FISCHER,M.T.STUBBS,D.M.FERRARITITL CRYSTAL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE PROTEINTITL 2 DISULFIDE ISOMERASE-RELATED PROTEIN ERP29.REF J.MOL.BIOL. V. 385 1630 2009REFN ISSN 0022-2836PMID 19084538DOI 10.1016/J.JMB.2008.11.052 Variant Set Distributions Mapped Variants
General Structure Information 4fss RASA1 crystal structure of a ras p21 protein activator (rasa1) from homo sapiens at 2.25 a resolution 2.25Å AUTH JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG),AUTH 2 PARTNERSHIP FOR T-CELL BIOLOGY (TCELL)TITL CRYSTAL STRUCTURE OF A RAS P21 PROTEIN ACTIVATOR (RASA1)TITL 2 FROM HOMO SAPIENS AT 2.25 A RESOLUTIONREF TO BE PUBLISHEDREFN […]
General Structure Information 3umn LMNB1 crystal structure of lamin-b1 2.0Å AUTH J.RUAN,C.XU,C.BIAN,R.LAM,J.P.WANG,J.KANIA,J.MIN,J.ZANGTITL CRYSTAL STRUCTURES OF THE COIL 2B FRAGMENT AND THE GLOBULARTITL 2 TAIL DOMAIN OF HUMAN LAMIN B1.REF FEBS LETT. V. 586 314 2012REFN ISSN 0014-5793PMID 22265972DOI 10.1016/J.FEBSLET.2012.01.007 Variant Set Distributions Mapped Variants
General Structure Information 3kex ERBB3 crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (her3) 2.8Å AUTH N.JURA,Y.SHAN,X.CAO,D.E.SHAW,J.KURIYANTITL STRUCTURAL ANALYSIS OF THE CATALYTICALLY INACTIVETITL 2 KINASE DOMAIN OF THE HUMAN EGF RECEPTOR 3.REF PROC.NATL.ACAD.SCI.USA V. 106 21608 2009REFN ISSN 0027-8424PMID 20007378DOI 10.1073/PNAS.0912101106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1iil FGFR2 crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 2.3Å AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rbl TNC high resolution design of a protein loop 2.1Å AUTH X.HU,H.WANG,H.KE,B.KUHLMANTITL HIGH-RESOLUTION DESIGN OF A PROTEIN LOOP.REF PROC.NATL.ACAD.SCI.USA V. 104 17668 2007REFN ISSN 0027-8424PMID 17971437DOI 10.1073/PNAS.0707977104 Variant Set Distributions Mapped Variants
General Structure Information 1x5z PTPRD solution structure of the fibronectin type-iii domain of human protein tyrosine phosphatase, receptor type, d isoform 4 variant -1.0Å AUTH M.YONEYAMA,K.SAITO,N.TOCHIO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIBRONECTIN TYPE-IIITITL 2 DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE,TITL 3 RECEPTOR TYPE, D ISOFORM 4 VARIANTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s […]
General Structure Information 2e2x NF1 sec14 homology module of neurofibromin in complex with phosphatitylethanolamine 2.5Å AUTH S.WELTI,S.FRATERMAN,I.DANGELO,M.WILM,K.SCHEFFZEKTITL THE SEC14 HOMOLOGY MODULE OF NEUROFIBROMIN BINDSTITL 2 CELLULAR GLYCEROPHOSPHOLIPIDS: MASS SPECTROMETRYTITL 3 AND STRUCTURE OF A LIPID COMPLEXREF J.MOL.BIOL. V. 366 551 2007REFN ISSN 0022-2836PMID 17187824DOI 10.1016/J.JMB.2006.11.055 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2v5y PTPRM crystal structure of the receptor protein tyrosine phosphatase mu ectodomain 3.1Å AUTH A.R.ARICESCU,C.SIEBOLD,K.CHOUDHURI,V.T.CHANG,W.LU,S.J.DAVIS,AUTH 2 P.A.VAN DER MERWE,E.Y.JONESTITL STRUCTURE OF A TYROSINE PHOSPHATASE ADHESIVE INTERACTIONTITL 2 REVEALS A SPACER-CLAMP MECHANISM.REF SCIENCE V. 317 1217 2007REFN ISSN 0036-8075PMID 17761881DOI 10.1126/SCIENCE.1144646 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants