Assessment of Structural Intolerance and Durability
General Structure Information 3pd7 TOPBP1 crystal structure of the sixth brct domain of human topbp1 1.26Å AUTH J.LEE,C.XU,G.CUI,J.R.THOMPSON,G.MERTITL CRYSTAL STRUCTURE OF THE SIXTH BRCT DOMAIN OF HUMAN TOPBP1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1j4w FUBP1 complex of the kh3 and kh4 domains of fbp with a single_stranded 29mer dna oligonucleotide from the fuse element of the c-myc oncogene -1.0Å AUTH D.T.BRADDOCK,J.M.LOUIS,J.L.BABER,D.LEVENS,G.M.CLORETITL STRUCTURE AND DYNAMICS OF KH DOMAINS FROM FBPTITL 2 BOUND TO SINGLE-STRANDED DNA.REF NATURE V. 415 1051 2002REFN ISSN 0028-0836PMID 11875576DOI 10.1038/4151051A Variant Set […]
General Structure Information 3al2 TOPBP1 crystal structure of topbp1 brct7/8 2.0Å AUTH C.C.LEUNG,Z.GONG,J.CHEN,J.N.GLOVERTITL MOLECULAR BASIS OF BACH1/FANCJ RECOGNITION BY TOPBP1 IN DNATITL 2 REPLICATION CHECKPOINT CONTROLREF J.BIOL.CHEM. V. 286 4292 2011REFN ISSN 0021-9258PMID 21127055DOI 10.1074/JBC.M110.189555 Variant Set Distributions Mapped Variants
General Structure Information 2ziv EME1 crystal structure of the mus81-eme1 complex 2.7Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Mapped Variants
General Structure Information 3dqv CUL5 structural insights into nedd8 activation of cullin-ring ligases: conformational control of conjugation 3.0Å AUTH D.M.DUDA,L.A.BORG,D.C.SCOTT,H.W.HUNT,M.HAMMEL,AUTH 2 B.A.SCHULMANTITL STRUCTURAL INSIGHTS INTO NEDD8 ACTIVATION OFTITL 2 CULLIN-RING LIGASES: CONFORMATIONAL CONTROL OFTITL 3 CONJUGATION.REF CELL(CAMBRIDGE,MASS.) V. 134 995 2008REFN ISSN 0092-8674PMID 18805092DOI 10.1016/J.CELL.2008.07.022 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3ei4 DDB2 structure of the hsddb1-hsddb2 complex 3.3Å AUTH A.SCRIMA,R.KONICKOVA,B.K.CZYZEWSKI,Y.KAWASAKI,P.D.JEFFREY,AUTH 2 R.GROISMAN,Y.NAKATANI,S.IWAI,N.P.PAVLETICH,N.H.THOMATITL STRUCTURAL BASIS OF UV DNA-DAMAGE RECOGNITION BY THETITL 2 DDB1-DDB2 COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 135 1213 2008REFN ISSN 0092-8674PMID 19109893DOI 10.1016/J.CELL.2008.10.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kt9 APTX aprataxin fha domain 1.65Å AUTH O.J.BECHEREL,B.JAKOB,A.L.CHERRY,N.GUEVEN,M.FUSSER,AUTH 2 A.W.KIJAS,C.PENG,S.KATYAL,P.J.MCKINNON,J.CHEN,AUTH 3 B.EPE,S.J.SMERDON,G.TAUCHER-SCHOLZ,M.F.LAVINTITL CK2 PHOSPHORYLATION-DEPENDENT INTERACTION BETWEENTITL 2 APRATAXIN AND MDC1 IN THE DNA DAMAGE RESPONSE.REF NUCLEIC ACIDS RES. V. 38 1489 2010REFN ISSN 0305-1048PMID 20008512DOI 10.1093/NAR/GKP1149 Variant Set Distributions Mapped Variants
General Structure Information 3rco TDRD7 crystal structure of a conserved motif in human tdrd7 1.8Å AUTH C.XU,A.DONG,J.R.WALKER,R.LAM,Y.GUO,C.BIAN,Y.LI,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF A CONSERVED MOTIF IN HUMAN TDRD7REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4drb FANCM the crystal structure of fancm bound mhf complex 2.63Å AUTH Y.TAO,C.JIN,X.LI,S.QI,L.CHU,L.NIU,X.YAO,M.TENGTITL THE STRUCTURE OF THE FANCM-MHF COMPLEX REVEALS PHYSICALTITL 2 FEATURES FOR FUNCTIONAL ASSEMBLYREF NAT COMMUN V. 3 782 2012REFN ESSN 2041-1723PMID 22510687DOI 10.1038/NCOMMS1779 Variant Set Distributions Mapped Variants
General Structure Information 2kuo APLF structure and identification of adp-ribose recognition motifs of aplf and role in the dna damage response -1.0Å AUTH G.Y.LI,R.D.MCCULLOCH,A.FENTON,M.CHEUNG,L.MENG,M.IKURA,AUTH 2 C.A.KOCHTITL STRUCTURE AND IDENTIFICATION OF ADP-RIBOSE RECOGNITIONTITL 2 MOTIFS OF APRATAXIN PNK-LIKE FACTOR (APLF) REQUIRED FOR THETITL 3 INTERACTION WITH SITES OF DNA DAMAGE RESPONSEREF TO BE PUBLISHEDREFN Variant Set […]