Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3llr DNMT3A crystal structure of the pwwp domain of human dna (cytosine-5-)- methyltransferase 3 alpha 2.3Å AUTH H.WU,H.ZENG,R.LAM,W.TEMPEL,M.F.AMAYA,C.XU,L.DOMBROVSKI,AUTH 2 W.QIU,Y.WANG,J.MINTITL STRUCTURAL AND HISTONE BINDING ABILITY CHARACTERIZATIONS OFTITL 2 HUMAN PWWP DOMAINS.REF PLOS ONE V. 6 18919 2011REFN ESSN 1932-6203PMID 21720545DOI 10.1371/JOURNAL.PONE.0018919 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3a1b DNMT3A crystal structure of the dnmt3a add domain in complex with histone h3 2.29Å AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2dmp ZHX2 solution structure of the third homeobox domain of zinc fingers and homeoboxes protein 2 -1.0Å AUTH S.OHNISHI,A.SASAGAWA,K.SAITO,S.KOSHIBA,M.INOUE,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD HOMEOBOX DOMAIN OFTITL 2 ZINC FINGERS AND HOMEOBOXES PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dl3 POLH human dna polymerase eta inserting dcmpnpp opposite gg template (gg0b). 2.1Å AUTH Y.ZHAO,C.BIERTUMPFEL,M.T.GREGORY,Y.J.HUA,F.HANAOKA,W.YANGTITL STRUCTURAL BASIS FOR CHEMORESISTANCE TO CISPLATIN MEDIATEDTITL 2 BY DNA POLYMERASE ETAREF PROC.NATL.ACAD.SCI.USA V. 109 7269 2012REFN ISSN 0027-8424PMID 22529383DOI 10.1073/PNAS.1202681109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3uk6 RUVBL2 crystal structure of the tip48 (tip49b) hexamer 2.95Å AUTH M.PETUKHOV,A.DAGKESSAMANSKAJA,M.BOMMER,T.BARRETT,I.TSANEVA,AUTH 2 A.YAKIMOV,R.QUEVAL,A.SHVETSOV,M.KHODORKOVSKIY,E.KAS,AUTH 3 M.GRIGORIEVTITL LARGE-SCALE CONFORMATIONAL FLEXIBILITY DETERMINES THETITL 2 PROPERTIES OF AAA+ TIP49 ATPASES.REF STRUCTURE V. 20 1321 2012REFN ISSN 0969-2126PMID 22748767DOI 10.1016/J.STR.2012.05.012 Variant Set Distributions Mapped Variants
General Structure Information 2e5r DTNA solution structure of the zz domain of dystrobrevin alpha (dystrobrevin-alpha) -1.0Å AUTH W.DANG,Y.MUTO,M.INOUE,T.KIGAWA,M.SHIROUZU,T.TERADA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZZ DOMAIN OFTITL 2 DYSTROBREVIN ALPHA (DYSTROBREVIN-ALPHA)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2eoc PARP3 solution structure of the wgr domain from human poly [adp- ribose] polymerase-3 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE WGR DOMAIN FROM HUMANTITL 2 POLY [ADP-RIBOSE] POLYMERASE-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ch0 LEMD3 solution structure of the human man1 c-terminal domain (residues 655-775) -1.0Å AUTH S.CAPUTO,J.COUPRIE,I.DUBAND-GOULET,F.LIN,S.BRAUD,AUTH 2 M.GONDRY,H.J.WORMAN,B.GILQUIN,S.ZINN-JUSTINTITL THE CARBOXYL-TERMINAL NUCLEOPLASMIC REGION OF MAN1TITL 2 EXHIBITS A DNA BINDING WINGED HELIX DOMAIN.REF J.BIOL.CHEM. V. 281 18208 2006REFN ISSN 0021-9258PMID 16648637DOI 10.1074/JBC.M601980200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3aqq CARHSP1 crystal structure of human crhsp-24 2.8Å AUTH H.HOU,F.WANG,W.ZHANG,D.WANG,X.LI,M.BARTLAM,X.YAO,Z.RAOTITL CRHSP-24 IS A NOVEL CARGO ADAPTOR TRAFFICKING BETWEEN STRESSTITL 2 GRANULES AND PROCESSING BODIESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants