Assessment of Structural Intolerance and Durability
General Structure Information 2p2r PCBP2 crystal structure of the third kh domain of human poly(c)- binding protein-2 in complex with c-rich strand of human telomeric dna 1.6Å AUTH S.FENN,Z.DU,J.K.LEE,R.TJHEN,R.M.STROUD,T.L.JAMESTITL CRYSTAL STRUCTURE OF THE THIRD KH DOMAIN OF HUMANTITL 2 POLY(C)-BINDING PROTEIN-2 IN COMPLEX WITH A C-RICHTITL 3 STRAND OF HUMAN TELOMERIC DNA AT 1.6 A […]
General Structure Information 3fzt PTK2B crystal structure of pyk2 complexed with pf-4618433 1.95Å AUTH S.HAN,A.MISTRY,J.S.CHANG,D.CUNNINGHAM,M.GRIFFOR,AUTH 2 P.C.BONNETTE,H.WANG,B.A.CHRUNYK,G.E.ASPNES,AUTH 3 D.P.WALKER,A.D.BROSIUS,L.BUCKBINDERTITL STRUCTURAL CHARACTERIZATION OF PROLINE-RICHTITL 2 TYROSINE KINASE 2 (PYK2) REVEALS A UNIQUE (DFG-OUT)TITL 3 CONFORMATION AND ENABLES INHIBITOR DESIGN.REF J.BIOL.CHEM. V. 284 13193 2009REFN ISSN 0021-9258PMID 19244237DOI 10.1074/JBC.M809038200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4dpg KARS crystal structure of human lysrs: p38/aimp2 complex i 2.84Å AUTH Y.OFIR-BIRIN,P.FANG,S.P.BENNETT,H.M.ZHANG,J.WANG,I.RACHMIN,AUTH 2 R.SHAPIRO,J.SONG,A.DAGAN,J.POZO,S.KIM,A.G.MARSHALL,AUTH 3 P.SCHIMMEL,X.L.YANG,H.NECHUSHTAN,E.RAZIN,M.GUOTITL STRUCTURAL SWITCH OF LYSYL-TRNA SYNTHETASE BETWEENTITL 2 TRANSLATION AND TRANSCRIPTION.REF MOL.CELL V. 49 30 2013REFN ISSN 1097-2765PMID 23159739DOI 10.1016/J.MOLCEL.2012.10.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dpg KARS crystal structure of human lysrs: p38/aimp2 complex i 2.84Å AUTH Y.OFIR-BIRIN,P.FANG,S.P.BENNETT,H.M.ZHANG,J.WANG,I.RACHMIN,AUTH 2 R.SHAPIRO,J.SONG,A.DAGAN,J.POZO,S.KIM,A.G.MARSHALL,AUTH 3 P.SCHIMMEL,X.L.YANG,H.NECHUSHTAN,E.RAZIN,M.GUOTITL STRUCTURAL SWITCH OF LYSYL-TRNA SYNTHETASE BETWEENTITL 2 TRANSLATION AND TRANSCRIPTION.REF MOL.CELL V. 49 30 2013REFN ISSN 1097-2765PMID 23159739DOI 10.1016/J.MOLCEL.2012.10.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dpg KARS crystal structure of human lysrs: p38/aimp2 complex i 2.84Å AUTH Y.OFIR-BIRIN,P.FANG,S.P.BENNETT,H.M.ZHANG,J.WANG,I.RACHMIN,AUTH 2 R.SHAPIRO,J.SONG,A.DAGAN,J.POZO,S.KIM,A.G.MARSHALL,AUTH 3 P.SCHIMMEL,X.L.YANG,H.NECHUSHTAN,E.RAZIN,M.GUOTITL STRUCTURAL SWITCH OF LYSYL-TRNA SYNTHETASE BETWEENTITL 2 TRANSLATION AND TRANSCRIPTION.REF MOL.CELL V. 49 30 2013REFN ISSN 1097-2765PMID 23159739DOI 10.1016/J.MOLCEL.2012.10.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a0l CUL4B structure of ddb1-ddb2-cul4b-rbx1 bound to a 12 bp abasic site containing dna-duplex 7.4Å AUTH E.S.FISCHER,A.SCRIMA,K.BOHM,S.MATSUMOTO,G.M.LINGARAJU,AUTH 2 M.FATY,T.YASUDA,S.CAVADINI,M.WAKASUGI,F.HANAOKA,S.IWAI,AUTH 3 H.GUT,K.SUGASAWA,N.H.THOMATITL THE MOLECULAR BASIS OF CRL4(DDB2/CSA) UBIQUITIN LIGASETITL 2 ARCHITECTURE, TARGETING, AND ACTIVATION.REF CELL(CAMBRIDGE,MASS.) V. 147 1024 2011REFN ISSN 0092-8674PMID 22118460DOI 10.1016/J.CELL.2011.10.035 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2qag SEPT6 crystal structure of human septin trimer 2/6/7 4.0Å AUTH M.SIRAJUDDIN,M.FARKASOVSKY,F.HAUER,D.KUHLMANN,AUTH 2 I.G.MACARA,M.WEYAND,H.STARK,A.WITTINGHOFERTITL STRUCTURAL INSIGHT INTO FILAMENT FORMATION BYTITL 2 MAMMALIAN SEPTINS.REF NATURE V. 449 311 2007REFN ISSN 0028-0836PMID 17637674DOI 10.1038/NATURE06052 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1xtj DDX39B structure of human uap56 in complex with adp 2.7Å AUTH H.SHI,O.CORDIN,C.M.MINDER,P.LINDER,R.-M.XUTITL CRYSTAL STRUCTURE OF THE HUMAN ATP-DEPENDENTTITL 2 SPLICING AND EXPORT FACTOR UAP56REF PROC.NATL.ACAD.SCI.USA V. 101 17628 2004REFN ISSN 0027-8424PMID 15585580DOI 10.1073/PNAS.0408172101 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3sde NONO crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3sde NONO crystal structure of a paraspeckle-protein heterodimer, pspc1/nono 1.9Å AUTH D.M.PASSON,M.LEE,O.RACKHAM,W.A.STANLEY,A.SADOWSKA,AUTH 2 A.FILIPOVSKA,A.H.FOX,C.S.BONDTITL STRUCTURE OF THE HETERODIMER OF HUMAN NONO AND PARASPECKLETITL 2 PROTEIN COMPONENT 1 AND ANALYSIS OF ITS ROLE IN SUBNUCLEARTITL 3 BODY FORMATION.REF PROC.NATL.ACAD.SCI.USA V. 109 4846 2012REFN ISSN 0027-8424PMID 22416126DOI 10.1073/PNAS.1120792109 Variant Set Distributions Ripley’s K Analysis […]