General Structure Information
| PDB ID | 4dpg |
| HGNC Gene Label(s) | KARS |
| Structure Name | crystal structure of human lysrs: p38/aimp2 complex i |
| Resolution | 2.84Å |
| Reference | AUTH Y.OFIR-BIRIN,P.FANG,S.P.BENNETT,H.M.ZHANG,J.WANG,I.RACHMIN,AUTH 2 R.SHAPIRO,J.SONG,A.DAGAN,J.POZO,S.KIM,A.G.MARSHALL,AUTH 3 P.SCHIMMEL,X.L.YANG,H.NECHUSHTAN,E.RAZIN,M.GUOTITL STRUCTURAL SWITCH OF LYSYL-TRNA SYNTHETASE BETWEENTITL 2 TRANSLATION AND TRANSCRIPTION.REF MOL.CELL V. 49 30 2013REFN ISSN 1097-2765PMID 23159739DOI 10.1016/J.MOLCEL.2012.10.010 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 505 |
| Number Of SNVs | 136 |
| Number Of Permutations | 73274 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.023 |
| p-value | 0.596 |
ClinVar
| Number Of Residues | 505 |
| Number Of SNVs | 3 |
| Number Of Permutations | 365 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 0.65 |
COSMIC
| Number Of Residues | 505 |
| Number Of SNVs | 4 |
| Number Of Permutations | 24 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.012 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 136 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.238 |
| p-value | 0.588 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 136 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.315 |
| p-value | 0.055 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
