Assessment of Structural Intolerance and Durability
General Structure Information 4bkx HDAC1 the structure of hdac1 in complex with the dimeric elm2-sant domain of mta1 from the nurd complex 3.0Å AUTH C.J.MILLARD,P.J.WATSON,I.CELARDO,Y.GORDIYENKO,S.M.COWLEY,AUTH 2 C.V.ROBINSON,L.FAIRALL,J.W.R.SCHWABETITL CLASS I HDACS SHARE A COMMON MECHANISM OF REGULATION BYTITL 2 INOSITOL PHOSPHATES.REF MOL.CELL V. 51 57 2013REFN ISSN 1097-2765PMID 23791785DOI 10.1016/J.MOLCEL.2013.05.020 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4fg8 CAMK1 crystal structure of human calcium/calmodulin-dependent protein kinase i 1-315 in complex with atp 2.2Å AUTH M.ZHA,C.ZHONG,Y.OU,L.HAN,J.WANG,J.DINGTITL CRYSTAL STRUCTURES OF HUMAN CAMKIALPHA REVEAL INSIGHTS INTOTITL 2 THE REGULATION MECHANISM OF CAMKI.REF PLOS ONE V. 7 44828 2012REFN ESSN 1932-6203PMID 23028635DOI 10.1371/JOURNAL.PONE.0044828 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3orh GAMT human guanidinoacetate n-methyltransferase with sah 1.86Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN GUANIDINOACETATETITL 2 N-METHYLTRANSFERASE WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2oo1 BRD3 crystal structure of the bromo domain 2 of human bromodomain containing protein 3 (brd3) 1.7Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4cnc TPBG crystal structure of human 5t4 (wnt-activated inhibitory factor 1, trophoblast glycoprotein) 1.77Å AUTH Y.ZHAO,T.MALINAUSKAS,K.HARLOS,E.Y.JONESTITL STRUCTURAL INSIGHTS INTO THE INHIBITION OF WNT SIGNALING BYTITL 2 CANCER ANTIGEN 5T4/WNT-ACTIVATED INHIBITORY FACTOR 1.REF STRUCTURE V. 22 612 2014REFN ISSN 0969-2126PMID 24582434DOI 10.1016/J.STR.2014.01.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1xv9 NR1I3 crystal structure of car/rxr heterodimer bound with src1 peptide, fatty acid, and 5b-pregnane-3,20-dione. 2.7Å AUTH R.X.XU,M.H.LAMBERT,B.B.WISELY,E.N.WARREN,AUTH 2 E.E.WEINERT,G.M.WAITT,J.D.WILLIAMS,J.L.COLLINS,AUTH 3 L.B.MOORE,T.M.WILLSON,J.T.MOORETITL A STRUCTURAL BASIS FOR CONSTITUTIVE ACTIVITY INTITL 2 THE HUMAN CAR/RXRALPHA HETERODIMER.REF MOL.CELL V. 16 919 2004REFN ISSN 1097-2765PMID 15610735DOI 10.1016/J.MOLCEL.2004.11.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3sm9 GRM3 crystal structure of metabotropic glutamate receptor 3 precursor in presence of ly341495 antagonist 2.26Å AUTH A.K.WERNIMONT,A.DONG,A.SEITOVA,L.CROMBET,G.KHUTORESKAYA,AUTH 2 A.M.EDWARDS,C.H.ARROWSMITH,C.BOUNTRA,J.WEIGELT,D.COSSAR,AUTH 3 E.DOBROVETSKYTITL CRYSTAL STRUCTURE OF METABOTROPIC GLUTAMATE RECEPTOR 3TITL 2 PRECURSOR IN PRESENCE OF LY341495 ANTAGONISTREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1by1 ARHGEF7 dbl homology domain from beta-pix -1.0Å AUTH B.AGHAZADEH,K.ZHU,T.J.KUBISESKI,G.A.LIU,T.PAWSON,AUTH 2 Y.ZHENG,M.K.ROSENTITL STRUCTURE AND MUTAGENESIS OF THE DBL HOMOLOGYTITL 2 DOMAINREF NAT.STRUCT.BIOL. V. 5 1098 1998REFN ISSN 1072-8368PMID 9846881DOI 10.1038/4209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2j3g FCN2 l-ficolin 2.5Å AUTH V.GARLATTI,N.BELLOY,L.MARTIN,M.LACROIX,AUTH 2 M.MATSUSHITA,Y.ENDO,T.FUJITA,J.C.FONTECILLA-CAMPS,AUTH 3 G.J.ARLAUD,N.M.THIELENS,C.GABORIAUDTITL STRUCTURAL INSIGHTS INTO THE INNATE IMMUNETITL 2 RECOGNITION SPECIFICITIES OF L- AND H-FICOLINS.REF EMBO J. V. 26 623 2007REFN ISSN 0261-4189PMID 17215869DOI 10.1038/SJ.EMBOJ.7601500 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants