Assessment of Structural Intolerance and Durability
General Structure Information 3dyt SNX9 crystal structure of snx9px-bar (230-595), c2221 2.08Å AUTH Q.WANG,H.Y.KAAN,R.N.HOODA,S.L.GOH,H.SONDERMANNTITL STRUCTURE AND PLASTICITY OF ENDOPHILIN AND SORTINGTITL 2 NEXIN 9.REF STRUCTURE V. 16 1574 2008REFN ISSN 0969-2126PMID 18940612DOI 10.1016/J.STR.2008.07.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rpn GSTK1 crystal structure of human kappa class glutathione transferase in complex with s-hexylglutathione 1.9Å AUTH B.WANG,Y.PENG,T.ZHANG,J.DINGTITL CRYSTAL STRUCTURES AND KINETIC STUDIES OF HUMAN KAPPA CLASSTITL 2 GLUTATHIONE TRANSFERASE PROVIDE INSIGHTS INTO THE CATALYTICTITL 3 MECHANISM.REF BIOCHEM.J. V. 439 215 2011REFN ISSN 0264-6021PMID 21728995DOI 10.1042/BJ20110753 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1pc2 FIS1 solution structure of human mitochondria fission protein fis1 -1.0Å AUTH M.SUZUKI,S.Y.JEONG,M.KARBOWSKI,R.J.YOULE,N.TJANDRATITL THE SOLUTION STRUCTURE OF HUMAN MITOCHONDRIATITL 2 FISSION PROTEIN FIS1 REVEALS A NOVEL TPR-LIKETITL 3 HELIX BUNDLEREF J.MOL.BIOL. V. 334 445 2003REFN ISSN 0022-2836PMID 14623186DOI 10.1016/J.JMB.2003.09.064 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v9r ROBO1 first and second ig domains from human robo1 (form 2) 2.0Å AUTH C.MORLOT,N.M.THIELENS,R.B.RAVELLI,W.HEMRIKA,R.A.ROMIJN,AUTH 2 P.GROS,S.CUSACK,A.A.MCCARTHYTITL STRUCTURAL INSIGHTS INTO THE SLIT-ROBO COMPLEX.REF PROC.NAT.ACAD.SCI.USA V. 104 14923 2007REFN ISSN 0027-8424PMID 17848514DOI 10.1073/PNAS.0705310104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3c5w PPME1 complex between pp2a-specific methylesterase pme-1 and pp2a core enzyme 2.8Å AUTH Y.XING,Z.LI,Y.CHEN,J.B.STOCK,P.D.JEFFREY,Y.SHITITL STRUCTURAL MECHANISM OF DEMETHYLATION AND INACTIVATION OFTITL 2 PROTEIN PHOSPHATASE 2A.REF CELL(CAMBRIDGE,MASS.) V. 133 154 2008REFN ISSN 0092-8674PMID 18394995DOI 10.1016/J.CELL.2008.02.041 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1p22 BTRC structure of a beta-trcp1-skp1-beta-catenin complex: destruction motif binding and lysine specificity on the scfbeta-trcp1 ubiquitin ligase 2.95Å AUTH G.WU,G.XU,B.A.SCHULMAN,P.D.JEFFREY,J.W.HARPER,AUTH 2 N.P.PAVLETICHTITL STRUCTURE OF A BETA-TRCP1-SKP1-BETA-CATENINTITL 2 COMPLEX: DESTRUCTION MOTIF BINDING AND LYSINETITL 3 SPECIFICITY OF THE SCFBETA-TRCP1 UBIQUITIN LIGASEREF MOL.CELL V. 11 1445 2003REFN ISSN 1097-2765PMID 12820959DOI 10.1016/S1097-2765(03)00234-X Variant Set […]
General Structure Information 4nh3 DICER1 structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5-pu and uu-3 ends (2.6 angstrom resolution) 2.62Å AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,J.E.PARK,I.HEO,V.N.KIM,D.J.PATELTITL A PHOSPHATE-BINDING POCKET WITHIN THE PLATFORM-PAZ-CONNECTORTITL 2 HELIX CASSETTE OF HUMAN DICER.REF MOL.CELL V. 53 606 2014REFN ISSN 1097-2765PMID 24486018DOI 10.1016/J.MOLCEL.2014.01.003 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2ice VSIG4 crig bound to c3c 3.1Å AUTH C.WIESMANN,K.J.KATSCHKE,J.YIN,K.Y.HELMY,M.STEFFEK,AUTH 2 W.J.FAIRBROTHER,S.A.MCCALLUM,L.EMBUSCADO,L.DEFORGE,P.E.HASS,AUTH 3 M.VAN LOOKEREN CAMPAGNETITL STRUCTURE OF C3B IN COMPLEX WITH CRIG GIVES INSIGHTS INTOTITL 2 REGULATION OF COMPLEMENT ACTIVATION.REF NATURE V. 444 217 2006REFN ISSN 0028-0836PMID 17051150DOI 10.1038/NATURE05263 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4kc9 ARIH1 structure of hhari, a ring-ibr-ring ubiquitin ligase: autoinhibition of an ariadne-family e3 and insights into ligation mechanism 3.6Å AUTH D.M.DUDA,J.L.OLSZEWSKI,J.P.SCHUERMANN,I.KURINOV,D.J.MILLER,AUTH 2 A.NOURSE,A.F.ALPI,B.A.SCHULMANTITL STRUCTURE OF HHARI, A RING-IBR-RING UBIQUITIN LIGASE:TITL 2 AUTOINHIBITION OF AN ARIADNE-FAMILY E3 AND INSIGHTS INTOTITL 3 LIGATION MECHANISM.REF STRUCTURE V. 21 1030 2013REFN ISSN 0969-2126PMID 23707686DOI 10.1016/J.STR.2013.04.019 […]
General Structure Information 3ff3 NAALAD2 the high resolution structure of human glutamate carboxypeptidase iii (gcpiii/naaladase ii) in complex with l-glutamate 1.37Å AUTH K.HLOUCHOVA,C.BARINKA,J.KONVALINKA,J.LUBKOWSKITITL STRUCTURAL INSIGHT INTO THE EVOLUTIONARY AND PHARMACOLOGICTITL 2 HOMOLOGY OF GLUTAMATE CARBOXYPEPTIDASES II AND IIIREF FEBS J. V. 276 4448 2009REFN ISSN 1742-464XPMID 19678840DOI 10.1111/J.1742-4658.2009.07152.X Variant Set Distributions Ripley’s K Analysis Plots […]