General Structure Information
| PDB ID | 4kc9 |
| HGNC Gene Label(s) | ARIH1 |
| Structure Name | structure of hhari, a ring-ibr-ring ubiquitin ligase: autoinhibition of an ariadne-family e3 and insights into ligation mechanism |
| Resolution | 3.6Å |
| Reference | AUTH D.M.DUDA,J.L.OLSZEWSKI,J.P.SCHUERMANN,I.KURINOV,D.J.MILLER,AUTH 2 A.NOURSE,A.F.ALPI,B.A.SCHULMANTITL STRUCTURE OF HHARI, A RING-IBR-RING UBIQUITIN LIGASE:TITL 2 AUTOINHIBITION OF AN ARIADNE-FAMILY E3 AND INSIGHTS INTOTITL 3 LIGATION MECHANISM.REF STRUCTURE V. 21 1030 2013REFN ISSN 0969-2126PMID 23707686DOI 10.1016/J.STR.2013.04.019 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 400 |
| Number Of SNVs | 18 |
| Number Of Permutations | 4935 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.026 |
| p-value | 0.03 |
COSMIC
| Number Of Residues | 400 |
| Number Of SNVs | 6 |
| Number Of Permutations | 3142 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.067 |
| p-value | 0.191 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.195 |
| p-value | 0.856 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
