Assessment of Structural Intolerance and Durability
General Structure Information 2dm4 SORL1 solution structure of the second fn3 domain of human sorla/lr11 -1.0Å AUTH T.NAGASHIMA,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN OFTITL 2 HUMAN SORLA/LR11REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2csz SYTL4 solution structure of the ring domain of the synaptotagmin- like protein 4 -1.0Å AUTH K.MIYAMOTO,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RING DOMAIN OF THETITL 2 SYNAPTOTAGMIN-LIKE PROTEIN 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3d68 CPB2 crystal structure of a t325i/t329i/h333y/h335q mutant of thrombin- activatable fibrinolysis inhibitor (tafi-iiyq) 2.8Å AUTH P.F.MARX,T.H.BRONDIJK,T.PLUG,R.A.ROMIJN,W.HEMRIKA,AUTH 2 J.C.M.MEIJERS,E.G.HUIZINGATITL CRYSTAL STRUCTURES OF TAFI ELUCIDATE THE INACTIVATIONTITL 2 MECHANISM OF ACTIVATED TAFI: A NOVEL MECHANISM FOR ENZYMETITL 3 AUTOREGULATIONREF BLOOD V. 112 2803 2008REFN ISSN 0006-4971PMID 18559974DOI 10.1182/BLOOD-2008-03-146001 Variant Set Distributions Ripley’s K […]
General Structure Information 3c9q WDYHV1 crystal structure of the uncharacterized human protein c8orf32 with bound peptide 1.5Å AUTH E.BITTO,C.A.BINGMAN,J.G.MCCOY,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF THE UNCHARACTERIZED HUMAN PROTEINTITL 2 C8ORF32 WITH BOUND PEPTIDE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4f9z ERP27 crystal structure of human erp27 2.2Å AUTH F.X.KOBER,W.KOELMEL,J.KUPER,J.DRECHSLER,C.MAIS,H.M.HERMANNS,AUTH 2 H.SCHINDELINTITL THE CRYSTAL STRUCTURE OF THE PROTEIN-DISULFIDE ISOMERASETITL 2 FAMILY MEMBER ERP27 PROVIDES INSIGHTS INTO ITS SUBSTRATETITL 3 BINDING CAPABILITIES.REF J.BIOL.CHEM. V. 288 2029 2013REFN ISSN 0021-9258PMID 23192347DOI 10.1074/JBC.M112.410522 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2vn8 RTN4IP1 crystal structure of human reticulon 4 interacting protein 1 in complex with nadph 2.1Å AUTH A.C.W.PIKE,K.GUO,J.ELKINS,E.UGOCHUKWU,A.K.ROOS,AUTH 2 P.FILIPPAKOPOULOS,F.VON DELFT,A.EDWARDS,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN RETICULON 4 INTERACTING PROTEINTITL 2 1 IN COMPLEX WITH NADPHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2rkb SDSL serine dehydratase like-1 from human cancer cells 2.8Å AUTH T.YAMADA,J.KOMOTO,T.KASUYA,Y.TAKATA,H.OGAWA,H.MORI,AUTH 2 F.TAKUSAGAWATITL A CATALYTIC MECHANISM THAT EXPLAINS A LOW CATALYTIC ACTIVITYTITL 2 OF SERINE DEHYDRATASE LIKE-1 FROM HUMAN CANCER CELLS:TITL 3 CRYSTAL STRUCTURE AND SITE-DIRECTED MUTAGENESIS STUDIES.REF BIOCHIM.BIOPHYS.ACTA V.1780 809 2008REFN ISSN 0006-3002PMID 18342636DOI 10.1016/J.BBAGEN.2008.01.020 Variant Set Distributions Ripley’s K […]
General Structure Information 2bei SAT2 x-ray structure of thialysine n-acetyltransferase (ssat2) from homo sapiens 1.84Å AUTH B.W.HAN,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS THIALYSINETITL 2 NEPSILON-ACETYLTRANSFERASE (HSSSAT2) IN COMPLEXTITL 3 WITH ACETYL COENZYME A.REF PROTEINS V. 64 288 2006REFN ISSN 0887-3585PMID 16596569DOI 10.1002/PROT.20967 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1y02 RFFL crystal structure of a fyve-type domain from caspase regulator carp2 1.8Å AUTH M.D.TIBBETTS,E.N.SHIOZAKI,L.GU,E.R.MCDONALD,AUTH 2 W.S.EL-DEIRY,Y.SHITITL CRYSTAL STRUCTURE OF A FYVE-TYPE ZINC FINGERTITL 2 DOMAIN FROM THE CASPASE REGULATOR CARP2.REF STRUCTURE V. 12 2257 2004REFN ISSN 0969-2126PMID 15576038DOI 10.1016/J.STR.2004.10.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4hlq TBC1D20 crystal structure of human rab1b bound to gdp and bef3 in complex with the gap domain of tbc1d20 from homo sapiens 3.3Å AUTH K.GAVRILJUK,E.M.GAZDAG,A.ITZEN,C.KOTTING,R.S.GOODY,K.GERWERTTITL CATALYTIC MECHANISM OF A MAMMALIAN RAB-RABGAP COMPLEX INTITL 2 ATOMIC DETAIL.REF PROC.NATL.ACAD.SCI.USA V. 109 21348 2012REFN ISSN 0027-8424PMID 23236136DOI 10.1073/PNAS.1214431110 Variant Set Distributions Ripley’s K Analysis […]