General Structure Information
| PDB ID | 4hlq |
| HGNC Gene Label(s) | TBC1D20 |
| Structure Name | crystal structure of human rab1b bound to gdp and bef3 in complex with the gap domain of tbc1d20 from homo sapiens |
| Resolution | 3.3Å |
| Reference | AUTH K.GAVRILJUK,E.M.GAZDAG,A.ITZEN,C.KOTTING,R.S.GOODY,K.GERWERTTITL CATALYTIC MECHANISM OF A MAMMALIAN RAB-RABGAP COMPLEX INTITL 2 ATOMIC DETAIL.REF PROC.NATL.ACAD.SCI.USA V. 109 21348 2012REFN ISSN 0027-8424PMID 23236136DOI 10.1073/PNAS.1214431110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 281 |
| Number Of SNVs | 60 |
| Number Of Permutations | 28837 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.021 |
| p-value | 0.816 |
COSMIC
| Number Of Residues | 281 |
| Number Of SNVs | 5 |
| Number Of Permutations | 182 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.1 |
| p-value | 0.485 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.168 |
| p-value | 0.898 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
