Assessment of Structural Intolerance and Durability
General Structure Information 3cok PLK4 crystal structure of plk4 kinase 2.25Å AUTH S.ATWELL,S.K.BURLEY,A.HOULE,B.LEON,L.A.PELLETIER,AUTH 2 J.M.SAUDERTITL CRYSTAL STRUCTURE OF PLK4 KINASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2csp RIMBP2 solution structure of the fniii domain of human rim-binding protein 2 -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FNIII DOMAIN OF HUMANTITL 2 RIM-BINDING PROTEIN 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tdc ACACB crystal structure of human acetyl-coa carboxylase 2 2.41Å AUTH T.YAMASHITA,M.KAMATA,S.ENDO,M.YAMAMOTO,K.KAKEGAWA,AUTH 2 H.WATANABE,K.MIWA,T.YAMANO,M.FUNATA,J.SAKAMOTO,A.TANI,AUTH 3 C.D.MOL,H.ZOU,D.R.DOUGAN,B.SANG,G.SNELL,K.FUKATSUTITL DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS OFTITL 2 SPIROLACTONES BEARING 2-UREIDOBENZOTHIOPHENE AS ACETYL-COATITL 3 CARBOXYLASES INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 21 6314 2011REFN ISSN 0960-894XPMID 21944854DOI 10.1016/J.BMCL.2011.08.117 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4hn2 PPIP5K2 crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp and a substrate analog 5pa-ip5 1.9Å AUTH A.M.RILEY,H.WANG,J.D.WEAVER,S.B.SHEARS,B.V.POTTERTITL FIRST SYNTHETIC ANALOGUES OF DIPHOSPHOINOSITOLTITL 2 POLYPHOSPHATES: INTERACTION WITH PP-INSP(5) KINASE.REF CHEM.COMMUN.(CAMB.) V. 48 11292 2012REFN ISSN 1359-7345PMID 23032903DOI 10.1039/C2CC36044F Variant Set Distributions Ripley’s K […]
General Structure Information 2a1x PHYH human phytanoyl-coa 2-hydroxylase in complex with iron and 2- oxoglutarate 2.5Å AUTH M.A.MCDONOUGH,K.L.KAVANAGH,D.BUTLER,T.SEARLES,U.OPPERMANN,AUTH 2 C.J.SCHOFIELDTITL STRUCTURE OF HUMAN PHYTANOYL-COA 2-HYDROXYLASE IDENTIFIESTITL 2 MOLECULAR MECHANISMS OF REFSUM DISEASEREF J.BIOL.CHEM. V. 280 41101 2005REFN ISSN 0021-9258PMID 16186124DOI 10.1074/JBC.M507528200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3b6u KIF3B crystal structure of the motor domain of human kinesin family member 3b in complex with adp 1.8Å AUTH H.ZHU,Y.SHEN,W.TEMPEL,R.LANDRY,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3B INTITL 2 COMPLEX WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4hdo KRIT1 crystal structure of the binary complex of krit1 bound to the rap1 gtpase 1.67Å AUTH A.R.GINGRAS,W.PUZON-MCLAUGHLIN,M.H.GINSBERGTITL THE STRUCTURE OF THE TERNARY COMPLEX OF KREV INTERACTIONTITL 2 TRAPPED 1 (KRIT1) BOUND TO BOTH THE RAP1 GTPASE AND THETITL 3 HEART OF GLASS (HEG1) CYTOPLASMIC TAIL.REF J.BIOL.CHEM. V. 288 23639 2013REFN ISSN […]
General Structure Information 4a9c INPPL1 crystal structure of human ship2 in complex with biphenyl 2,3,4,5,6-pentakisphosphate 2.1Å AUTH S.J.MILLS,C.PERSSON,G.COZIER,M.P.THOMAS,L.TRESAUGUES,AUTH 2 C.ERNEUX,A.M.RILEY,P.NORDLUND,B.V.L.POTTERTITL A SYNTHETIC POLYPHOSPHOINOSITIDE HEADGROUP SURROGATE INTITL 2 COMPLEX WITH SHIP2 PROVIDES A RATIONALE FOR DRUG DISCOVERY.REF ACS CHEM.BIOL. V. 7 822 2012REFN ISSN 1554-8929PMID 22330088DOI 10.1021/CB200494D Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2amy PMM2 x-ray structure of human phosphomannomutase 2 (pmm2) 2.09Å AUTH CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS (CESG)TITL X-RAY STRUCTURE OF HUMAN PHOSPHOMANNOMUTASE 2 (PMM2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3b6v KIF3C crystal structure of the motor domain of human kinesin family member 3c in complex with adp 2.7Å AUTH H.ZHU,W.TEMPEL,Y.SHEN,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3C IN COMPLEXTITL 2 WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]