Assessment of Structural Intolerance and Durability
General Structure Information 2i5f PLEK crystal structure of the c-terminal ph domain of pleckstrin in complex with d-myo-ins(1,2,3,5,6)p5 1.35Å AUTH S.G.JACKSON,Y.ZHANG,R.J.HASLAM,M.S.JUNOPTITL STRUCTURAL ANALYSIS OF THE CARBOXY TERMINAL PHTITL 2 DOMAIN OF PLECKSTRIN BOUND TO D-MYO-INOSITOLTITL 3 1,2,3,5,6-PENTAKISPHOSPHATE.REF BMC STRUCT.BIOL. V. 7 80 2007REFN ESSN 1472-6807PMID 18034889DOI 10.1186/1472-6807-7-80 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1slm MMP3 crystal structure of fibroblast stromelysin-1: the c-truncated human proenzyme 1.9Å AUTH J.W.BECKER,A.I.MARCY,L.L.ROKOSZ,M.G.AXEL,J.J.BURBAUM,AUTH 2 P.M.FITZGERALD,P.M.CAMERON,C.K.ESSER,W.K.HAGMANN,J.D.HERMES,AUTH 3 J.P.SPRINGERTITL STROMELYSIN-1: THREE-DIMENSIONAL STRUCTURE OF THE INHIBITEDTITL 2 CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME.REF PROTEIN SCI. V. 4 1966 1995REFN ISSN 0961-8368PMID 8535233 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3eqm CYP19A1 crystal structure of human placental aromatase cytochrome p450 in complex with androstenedione 2.9Å AUTH D.GHOSH,J.GRISWOLD,M.ERMAN,W.PANGBORNTITL STRUCTURAL BASIS FOR ANDROGEN SPECIFICITY AND OESTROGENTITL 2 SYNTHESIS IN HUMAN AROMATASE.REF NATURE V. 457 219 2009REFN ISSN 0028-0836PMID 19129847DOI 10.1038/NATURE07614 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1jfn LPA solution structure of human apolipoprotein(a) kringle iv type 6 -1.0Å AUTH B.MADEREGGER,W.BERMEL,A.HRZENJAK,G.M.KOSTNER,AUTH 2 H.STERKTITL SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A)TITL 2 KRINGLE IV TYPE 6.REF BIOCHEMISTRY V. 41 660 2002REFN ISSN 0006-2960PMID 11781107DOI 10.1021/BI011430K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lmf C1S c1s cub1-egf-cub2 2.92Å AUTH U.VENKATRAMAN GIRIJA,A.R.GINGRAS,J.E.MARSHALL,R.PANCHAL,AUTH 2 M.A.SHEIKH,P.GAL,W.J.SCHWAEBLE,D.A.MITCHELL,P.C.MOODY,AUTH 3 R.WALLISTITL STRUCTURAL BASIS OF THE C1Q/C1S INTERACTION AND ITS CENTRALTITL 2 ROLE IN ASSEMBLY OF THE C1 COMPLEX OF COMPLEMENT ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 110 13916 2013REFN ISSN 0027-8424PMID 23922389DOI 10.1073/PNAS.1311113110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3bg3 PC crystal structure of human pyruvate carboxylase (missing the biotin carboxylase domain at the n-terminus) 2.8Å AUTH S.XIANG,L.TONGTITL CRYSTAL STRUCTURES OF HUMAN AND STAPHYLOCOCCUSTITL 2 AUREUS PYRUVATE CARBOXYLASE AND MOLECULAR INSIGHTSTITL 3 INTO THE CARBOXYLTRANSFER REACTION.REF NAT.STRUCT.MOL.BIOL. V. 15 295 2008REFN ISSN 1545-9993PMID 18297087DOI 10.1038/NSMB.1393 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2cso PLEK solution structure of the dep domain of human pleckstrin -1.0Å AUTH K.INOUE,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE DEP DOMAIN OF HUMANTITL 2 PLECKSTRINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ouj THBS1 the crystal structure of the thrombospondin-1 n-terminal domain in complex with fractionated heparin dp8 1.9Å AUTH K.TAN,M.DUQUETTE,J.H.LIU,K.SHANMUGASUNDARAM,AUTH 2 A.JOACHIMIAK,J.T.GALLAGHER,A.C.RIGBY,J.H.WANG,AUTH 3 J.LAWLERTITL HEPARIN-INDUCED CIS- AND TRANS-DIMERIZATION MODESTITL 2 OF THE THROMBOSPONDIN-1 N-TERMINAL DOMAIN.REF J.BIOL.CHEM. V. 283 3932 2008REFN ISSN 0021-9258PMID 18065761DOI 10.1074/JBC.M705203200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2v5o IGF2R structure of human igf2r domains 11-14 2.91Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,R.J.GILBERT,AUTH 2 G.VAN BOXEL,A.DENLEY,J.C.WALLACE,A.B.HASSAN,B.E.FORBES,AUTH 3 E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE IGF-II/IGF2RTITL 2 INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1og2 CYP2C9 structure of human cytochrome p450 cyp2c9 2.6Å AUTH P.A.WILLIAMS,J.COSME,A.WARD,H.C.ANGOVE,AUTH 2 D.MATAK VINKOVIC,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 2C9TITL 2 WITH BOUND WARFARINREF NATURE V. 424 464 2003REFN ISSN 0028-0836PMID 12861225DOI 10.1038/NATURE01862 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants