Assessment of Structural Intolerance and Durability
General Structure Information 1wrm DUSP22 crystal structure of jsp-1 1.5Å AUTH T.YOKOTA,Y.NARA,A.KASHIMA,K.MATSUBARA,S.MISAWA,AUTH 2 R.KATO,S.SUGIOTITL CRYSTAL STRUCTURE OF HUMAN DUAL SPECIFICITYTITL 2 PHOSPHATASE, JNK STIMULATORY PHOSPHATASE-1, AT 1.5TITL 3 A RESOLUTIONREF PROTEINS V. 66 272 2006REFN ISSN 0887-3585PMID 17068812DOI 10.1002/PROT.21152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3pq1 MTPAP crystal structure of human mitochondrial poly(a) polymerase (papd1) 3.1Å AUTH Y.BAI,S.K.SRIVASTAVA,J.H.CHANG,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR DIMERIZATION AND ACTIVITY OF HUMANTITL 2 PAPD1, A NONCANONICAL POLY(A) POLYMERASE.REF MOL.CELL V. 41 311 2011REFN ISSN 1097-2765PMID 21292163DOI 10.1016/J.MOLCEL.2011.01.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4day RMI1 crystal structure of the rmi core complex with mm2 peptide from fancm 3.3Å AUTH K.A.HOADLEY,Y.XUE,C.LING,M.TAKATA,W.WANG,J.L.KECKTITL DEFINING THE MOLECULAR INTERFACE THAT CONNECTS THE FANCONITITL 2 ANEMIA PROTEIN FANCM TO THE BLOOM SYNDROME DISSOLVASOME.REF PROC.NATL.ACAD.SCI.USA V. 109 4437 2012REFN ISSN 0027-8424PMID 22392978DOI 10.1073/PNAS.1117279109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2yhf CLEC5A 1.9 angstrom crystal structure of clec5a 1.9Å AUTH A.A.WATSON,A.A.LEBEDEV,B.A.HALL,A.E.FENTON-MAY,AUTH 2 A.A.VAGIN,W.DEJNIRATTISAI,J.FELCE,J.MONGKOLSAPAYA,AUTH 3 A.S.PALMA,Y.LIU,T.FEIZI,G.R.SCREATON,G.N.MURSHUDOV,AUTH 4 C.A.OCALLAGHANTITL STRUCTURAL FLEXIBILITY OF THE MACROPHAGE DENGUETITL 2 VIRUS RECEPTOR CLEC5A: IMPLICATIONS FOR LIGANDTITL 3 BINDING AND SIGNALING.REF J.BIOL.CHEM. V. 286 24208 2011REFN ISSN 0021-9258PMID 21566123DOI 10.1074/JBC.M111.226142 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3mk6 PANK3 substrate and inhibitor binding to pank 1.98Å AUTH R.LEONARDI,Y.M.ZHANG,M.K.YUN,R.ZHOU,F.Y.ZENG,W.LIN,J.CUI,AUTH 2 T.CHEN,C.O.ROCK,S.W.WHITE,S.JACKOWSKITITL MODULATION OF PANTOTHENATE KINASE 3 ACTIVITY BY SMALLTITL 2 MOLECULES THAT INTERACT WITH THE SUBSTRATE/ALLOSTERICTITL 3 REGULATORY DOMAIN.REF CHEM.BIOL. V. 17 892 2010REFN ISSN 1074-5521PMID 20797618DOI 10.1016/J.CHEMBIOL.2010.06.006 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3a6p XPO5 crystal structure of exportin-5:rangtp:pre-mirna complex 2.92Å AUTH C.OKADA,E.YAMASHITA,S.J.LEE,S.SHIBATA,J.KATAHIRA,A.NAKAGAWA,AUTH 2 Y.YONEDA,T.TSUKIHARATITL A HIGH-RESOLUTION STRUCTURE OF THE PRE-MICRORNA NUCLEARTITL 2 EXPORT MACHINERYREF SCIENCE V. 326 1275 2009REFN ISSN 0036-8075PMID 19965479DOI 10.1126/SCIENCE.1178705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xsw INPP5E crystal structure of human inpp5e 1.9Å AUTH L.TRESAUGUES,P.SCHUTZ,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,H.SCHULER,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN INPP5EREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4m0a POLM human dna polymerase mu post-catalytic complex 1.85Å AUTH A.F.MOON,J.M.PRYOR,D.A.RAMSDEN,T.A.KUNKEL,K.BEBENEK,AUTH 2 L.C.PEDERSENTITL SUSTAINED ACTIVE SITE RIGIDITY DURING SYNTHESIS BY HUMAN DNATITL 2 POLYMERASE MU.REF NAT.STRUCT.MOL.BIOL. V. 21 253 2014REFN ISSN 1545-9993PMID 24487959DOI 10.1038/NSMB.2766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q3f RRAGD x-ray crystal structure of putative human ras-related gtp binding d in complex with gmppnp 2.1Å AUTH A.M.MULICHAK,W.M.RABEH,W.TEMPEL,L.NEDYALKOVA,AUTH 2 R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,AUTH 3 J.WEIGELT,L.J.KEEFE,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-RELATED GTP-BINDINGTITL 2 D.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1k9i CD209 complex of dc-sign and glcnac2man3 2.5Å AUTH H.FEINBERG,D.A.MITCHELL,K.DRICKAMER,W.I.WEISTITL STRUCTURAL BASIS FOR SELECTIVE RECOGNITION OFTITL 2 OLIGOSACCHARIDES BY DC-SIGN AND DC-SIGNR.REF SCIENCE V. 294 2163 2001REFN ISSN 0036-8075PMID 11739956DOI 10.1126/SCIENCE.1066371 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants