General Structure Information
| PDB ID | 3mk6 |
| HGNC Gene Label(s) | PANK3 |
| Structure Name | substrate and inhibitor binding to pank |
| Resolution | 1.98Å |
| Reference | AUTH R.LEONARDI,Y.M.ZHANG,M.K.YUN,R.ZHOU,F.Y.ZENG,W.LIN,J.CUI,AUTH 2 T.CHEN,C.O.ROCK,S.W.WHITE,S.JACKOWSKITITL MODULATION OF PANTOTHENATE KINASE 3 ACTIVITY BY SMALLTITL 2 MOLECULES THAT INTERACT WITH THE SUBSTRATE/ALLOSTERICTITL 3 REGULATORY DOMAIN.REF CHEM.BIOL. V. 17 892 2010REFN ISSN 1074-5521PMID 20797618DOI 10.1016/J.CHEMBIOL.2010.06.006 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 348 |
| Number Of SNVs | 52 |
| Number Of Permutations | 33142 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.041 |
| p-value | 0.313 |
COSMIC
| Number Of Residues | 348 |
| Number Of SNVs | 11 |
| Number Of Permutations | 4089 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.2 |
| p-value | 0.48 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.116 |
| p-value | 0.618 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
