Assessment of Structural Intolerance and Durability
General Structure Information 2fcb FCGR2B human fc gamma receptor iib ectodomain (cd32) 1.74Å AUTH P.SONDERMANN,R.HUBER,U.JACOBTITL CRYSTAL STRUCTURE OF THE SOLUBLE FORM OF THE HUMANTITL 2 FCGAMMA-RECEPTOR IIB: A NEW MEMBER OF THETITL 3 IMMUNOGLOBULIN SUPERFAMILY AT 1.7 A RESOLUTION.REF EMBO J. V. 18 1095 1999REFN ISSN 0261-4189PMID 10064577DOI 10.1093/EMBOJ/18.5.1095 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2wa0 MAGEA4 crystal structure of the human magea4 2.3Å AUTH A.K.ROOS,C.D.O.COOPER,E.UGOCHUKWU,W.W YUE,G.BERRIDGE,AUTH 2 J.M.ELKINS,A.C.W.PIKE,J.BRAY,P.FILIPPAKOPOULOS,J.MUNIZ,AUTH 3 A.CHAIKUAD,N.BURGESS-BROWN,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,C.BOUNTRA,F.VON DELFT,O.GILEADI,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN MAGEA4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2d8n RCVRN crystal structure of human recoverin at 2.2 a resolution 2.2Å AUTH S.KAMO,S.KISHISHITA,K.MURAYAMA,M.SHIROUZU,S.YOKOYAMATITL CRYSTAL STRUCTURE OF HUMAN RECOVERIN AT 2.2 A RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1ji7 ETV6 crystal structure of tel sam polymer 1.45Å AUTH C.A.KIM,M.L.PHILLIPS,W.KIM,M.GINGERY,H.H.TRAN,AUTH 2 M.A.ROBINSON,S.FAHAM,J.U.BOWIETITL POLYMERIZATION OF THE SAM DOMAIN OF TEL INTITL 2 LEUKEMOGENESIS AND TRANSCRIPTIONAL REPRESSION.REF EMBO J. V. 20 4173 2001REFN ISSN 0261-4189PMID 11483520DOI 10.1093/EMBOJ/20.15.4173 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3hmn TTK crystal structure of human mps1 catalytic domain in complex with atp 2.7Å AUTH M.L.CHU,Z.LANG,L.M.CHAVAS,J.NERES,O.S.FEDOROVA,L.TABERNERO,AUTH 2 M.CHERRY,D.H.WILLIAMS,K.T.DOUGLAS,P.A.EYERSTITL BIOPHYSICAL AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF MPS1TITL 2 KINASE INHIBITOR COMPLEXES.REF BIOCHEMISTRY V. 49 1689 2010REFN ISSN 0006-2960PMID 20099905DOI 10.1021/BI901970C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 3ou5 SHMT2 human mitochondrial serine hydroxymethyltransferase 2 2.04Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOV,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL SERINETITL 2 HYDROXYMETHYLTRANSFERASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3u8z NF2 human merlin ferm domain 2.64Å AUTH S.D.YOGESHA,A.J.SHARFF,M.GIOVANNINI,G.BRICOGNE,T.IZARDTITL UNFURLING OF THE BAND 4.1, EZRIN, RADIXIN, MOESIN (FERM)TITL 2 DOMAIN OF THE MERLIN TUMOR SUPPRESSOR.REF PROTEIN SCI. V. 20 2113 2011REFN ISSN 0961-8368PMID 22012890DOI 10.1002/PRO.751 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3o96 AKT1 crystal structure of human akt1 with an allosteric inhibitor 2.7Å AUTH W.I.WU,W.C.VOEGTLI,H.L.STURGIS,F.P.DIZON,G.P.VIGERS,AUTH 2 B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF HUMAN AKT1 WITH AN ALLOSTERIC INHIBITORTITL 2 REVEALS A NEW MODE OF KINASE INHIBITION.REF PLOS ONE V. 5 12913 2010REFN ESSN 1932-6203PMID 20886116DOI 10.1371/JOURNAL.PONE.0012913 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4dbu AKR1C3 crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (akr1c3) in complex with nadp+ and 3-((4 -(trifluoromethyl)phenyl) amino)benzoic acid 2.53Å AUTH M.CHEN,A.O.ADENIJI,B.M.TWENTER,J.D.WINKLER,D.W.CHRISTIANSON,AUTH 2 T.M.PENNINGTITL CRYSTAL STRUCTURES OF AKR1C3 CONTAINING ANTITL 2 N-(ARYL)AMINO-BENZOATE INHIBITOR AND A BIFUNCTIONAL AKR1C3TITL 3 INHIBITOR AND ANDROGEN RECEPTOR ANTAGONIST. THERAPEUTICTITL 4 LEADS FOR CASTRATE RESISTANT PROSTATE CANCER.REF […]
General Structure Information 1d1t ADH7 mutant of human sigma alcohol dehydrogenase with leucine at position 141 2.4Å AUTH P.T.XIE,T.D.HURLEYTITL METHIONINE-141 DIRECTLY INFLUENCES THE BINDING OFTITL 2 4-METHYLPYRAZOLE IN HUMAN SIGMA SIGMA ALCOHOL DEHYDROGENASE.REF PROTEIN SCI. V. 8 2639 1999REFN ISSN 0961-8368PMID 10631979 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants