General Structure Information 3alo MAP2K4 crystal structure of human non-phosphorylated mkk4 kinase domain ternary complex with amp-pnp and p38 peptide 2.6Å AUTH T.MATSUMOTO,T.KINOSHITA,Y.KIRII,K.YOKOTA,K.HAMADA,T.TADATITL CRYSTAL STRUCTURES OF MKK4 KINASE DOMAIN REVEAL THATTITL 2 SUBSTRATE PEPTIDE BINDS TO AN ALLOSTERIC SITE AND INDUCES ANTITL 3 AUTO-INHIBITION STATEREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 400 369 2010REFN ISSN 0006-291XPMID 20732303DOI 10.1016/J.BBRC.2010.08.071 Variant […]
General Structure Information 4cga CHKA human choline kinase a1 in complex with compound 5 1.74Å AUTH B.RUBIO-RUIZ,A.FIGUEROLA-CONCHAS,J.RAMOS-TORRECILLAS,AUTH 2 F.CAPITAN-CANADAS,P.RIOS-MARCO,M.P.CARRASCO,M.A.GALLO,AUTH 3 A.ESPINOSA,C.MARCO,C.CONCEPCION,A.ENTRENA-GUADIX,AUTH 4 R.HURTADO-GUERRERO,A.CONEJO-GARCIATITL DISCOVERY OF A NEW BINDING SITE ON HUMAN CHOLINE KINASE A1:TITL 2 DESIGN, SYNTHESIS, CRYSTALLOGRAPHIC STUDIES AND BIOLOGICALTITL 3 EVALUATION OF ASYMMETRICAL BISPYRIDINIUM DERIVATIVESREF J.MED.CHEM. V. 57 507 2014REFN ISSN 0022-2623PMID 24387243DOI […]
General Structure Information 2m74 FBN1 1h, 13c and 15n assignments of the four n-terminal domains of human fibrillin-1 -1.0Å AUTH D.A.YADIN,I.B.ROBERTSON,J.MCNAUGHT-DAVIS,P.EVANS,D.STODDART,AUTH 2 P.A.HANDFORD,S.A.JENSEN,C.REDFIELDTITL STRUCTURE OF THE FIBRILLIN-1 N-TERMINAL DOMAINS SUGGESTSTITL 2 THAT HEPARAN SULFATE REGULATES THE EARLY STAGES OFTITL 3 MICROFIBRIL ASSEMBLY.REF STRUCTURE V. 21 1743 2013REFN ISSN 0969-2126PMID 24035709DOI 10.1016/J.STR.2013.08.004 Variant Set Distributions Ripley’s […]
General Structure Information 1qqg IRS1 crystal structure of the ph-ptb targeting region of irs-1 2.3Å AUTH S.DHE-PAGANON,E.A.OTTINGER,R.T.NOLTE,M.J.ECK,AUTH 2 S.E.SHOELSONTITL CRYSTAL STRUCTURE OF THE PLECKSTRINTITL 2 HOMOLOGY-PHOSPHOTYROSINE BINDING (PH-PTB)TITL 3 TARGETING REGION OF INSULIN RECEPTOR SUBSTRATE 1.REF PROC.NATL.ACAD.SCI.USA V. 96 8378 1999REFN ISSN 0027-8424PMID 10411883DOI 10.1073/PNAS.96.15.8378 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1i8l CD80 human b7-1/ctla-4 co-stimulatory complex 3.0Å AUTH C.C.STAMPER,Y.ZHANG,J.F.TOBIN,D.V.ERBE,S.IKEMIZU,S.J.DAVIS,AUTH 2 M.L.STAHL,J.SEEHRA,W.S.SOMERS,L.MOSYAKTITL CRYSTAL STRUCTURE OF THE B7-1/CTLA-4 COMPLEX THAT INHIBITSTITL 2 HUMAN IMMUNE RESPONSES.REF NATURE V. 410 608 2001REFN ISSN 0028-0836PMID 11279502DOI 10.1038/35069118 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2x7o TGFBR1 crystal structure of tgfbri complexed with an indolinone inhibitor 3.7Å AUTH G.J.ROTH,A.HECKEL,T.BRANDL,M.GRAUERT,S.HOERER,J.T.KLEY,AUTH 2 G.SCHNAPP,P.BAUM,D.MENNERICH,A.SCHNAPP,J.E.PARKTITL DESIGN, SYNTHESIS AND EVALUATION OF INDOLINONES ASTITL 2 INHIBITORS OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTORTITL 3 I (TGFBRI)REF J.MED.CHEM. V. 53 7287 2010REFN ISSN 0022-2623PMID 20919678DOI 10.1021/JM100812A Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1efv ETFB three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution 2.1Å AUTH D.L.ROBERTS,F.E.FRERMAN,J.J.KIMTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN ELECTRONTITL 2 TRANSFER FLAVOPROTEIN TO 2.1-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 14355 1996REFN ISSN 0027-8424PMID 8962055DOI 10.1073/PNAS.93.25.14355 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2bwg GMPR structure of human guanosine monophosphate reductase gmpr1 in complex with gmp 2.4Å AUTH G.BUNKOCZI,A.HARONITI,S.NG,F.VON DELFT,O.GILEADI,AUTH 2 U.OPPERMANN,C.ARROWSMITH,A.EDWARDS,M.SUNDSTROMTITL STRUCTURE OF HUMAN GUANOSINE MONOPHOSPHATE REDUCTASE GMPR1TITL 2 IN COMPLEX WITH GMPREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fdj GALNS the molecular basis of mucopolysaccharidosis iv a, complex with galnac 2.81Å AUTH Y.RIVERA-COLON,E.K.SCHUTSKY,A.Z.KITA,S.C.GARMANTITL THE STRUCTURE OF HUMAN GALNS REVEALS THE MOLECULAR BASIS FORTITL 2 MUCOPOLYSACCHARIDOSIS IV A.REF J.MOL.BIOL. V. 423 736 2012REFN ISSN 0022-2836PMID 22940367DOI 10.1016/J.JMB.2012.08.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2m59 KDR spatial structure of dimeric vegfr2 membrane domain in dpc micelles -1.0Å AUTH K.S.MINEEV,A.S.ARSENIEV,M.A.SHULEPKO,E.N.LYUKMANOVATITL SPATIAL STRUCTURE OF DIMERIC VEGFR2 MEMBRANE DOMAIN IN DPCTITL 2 MICELLESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants