General Structure Information
| PDB ID | 1qqg |
| HGNC Gene Label(s) | IRS1 |
| Structure Name | crystal structure of the ph-ptb targeting region of irs-1 |
| Resolution | 2.3Å |
| Reference | AUTH S.DHE-PAGANON,E.A.OTTINGER,R.T.NOLTE,M.J.ECK,AUTH 2 S.E.SHOELSONTITL CRYSTAL STRUCTURE OF THE PLECKSTRINTITL 2 HOMOLOGY-PHOSPHOTYROSINE BINDING (PH-PTB)TITL 3 TARGETING REGION OF INSULIN RECEPTOR SUBSTRATE 1.REF PROC.NATL.ACAD.SCI.USA V. 96 8378 1999REFN ISSN 0027-8424PMID 10411883DOI 10.1073/PNAS.96.15.8378 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 207 |
| Number Of SNVs | 37 |
| Number Of Permutations | 23455 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.14 |
| p-value | 0.271 |
COSMIC
| Number Of Residues | 207 |
| Number Of SNVs | 3 |
| Number Of Permutations | 406 |
| Optimal Distance Threshold | 47.0 |
| K Statistic | 0.667 |
| p-value | 0.366 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.488 |
| p-value | 0.176 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
