General Structure Information
| PDB ID | 1i8l |
| HGNC Gene Label(s) | CD80 |
| Structure Name | human b7-1/ctla-4 co-stimulatory complex |
| Resolution | 3.0Å |
| Reference | AUTH C.C.STAMPER,Y.ZHANG,J.F.TOBIN,D.V.ERBE,S.IKEMIZU,S.J.DAVIS,AUTH 2 M.L.STAHL,J.SEEHRA,W.S.SOMERS,L.MOSYAKTITL CRYSTAL STRUCTURE OF THE B7-1/CTLA-4 COMPLEX THAT INHIBITSTITL 2 HUMAN IMMUNE RESPONSES.REF NATURE V. 410 608 2001REFN ISSN 0028-0836PMID 11279502DOI 10.1038/35069118 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 199 |
| Number Of SNVs | 51 |
| Number Of Permutations | 15987 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.085 |
| p-value | 0.239 |
COSMIC
| Number Of Residues | 199 |
| Number Of SNVs | 3 |
| Number Of Permutations | 102 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.538 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.204 |
| p-value | 0.751 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
