Assessment of Structural Intolerance and Durability
General Structure Information 2jri ATXN3 solution structure of the josephin domain of ataxin-3 in complex with ubiquitin molecule. -1.0Å AUTH G.NICASTRO,R.MENON,L.MASINO,A.PASTORETITL UNDERSTANDING THE PLASTICITY OF THETITL 2 UBIQUITIN-PROTEIN RECOGNITION CODE: THE JOSEPHINTITL 3 DOMAIN OF ATAXIN-3 IS A DIUBIQUITIN BINDING MOTIFREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3p0u NR2C2 crystal structure of the ligand binding domain of human testicular receptor 4 3.0Å AUTH X.E.ZHOU,K.M.SUINO-POWELL,Y.XU,C.W.CHAN,O.TANABE,S.W.KRUSE,AUTH 2 R.REYNOLDS,J.D.ENGEL,H.E.XUTITL THE ORPHAN NUCLEAR RECEPTOR TR4 IS A VITAMIN A-ACTIVATEDTITL 2 NUCLEAR RECEPTOR.REF J.BIOL.CHEM. V. 286 2877 2011REFN ISSN 0021-9258PMID 21068381DOI 10.1074/JBC.M110.168740 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3ii6 LIG4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Ripley’s K […]
General Structure Information 1xa6 CHN2 crystal structure of the human beta2-chimaerin 3.2Å AUTH B.CANAGARAJAH,F.C.LESKOW,J.Y.HO,H.MISCHAK,AUTH 2 L.F.SAIDI,M.G.KAZANIETZ,J.H.HURLEYTITL STRUCTURAL MECHANISM FOR LIPID ACTIVATION OF THETITL 2 RAC-SPECIFIC GAP, BETA2-CHIMAERIN.REF CELL(CAMBRIDGE,MASS.) V. 119 407 2004REFN ISSN 0092-8674PMID 15507211DOI 10.1016/J.CELL.2004.10.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bkt VHL von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide 2.35Å AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3wef FDFT1 crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate 2.35Å AUTH C.I.LIU,W.Y.JENG,W.J.CHANG,M.F.SHIH,T.P.KO,A.H.J.WANGTITL STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF HUMANTITL 2 SQUALENE SYNTHASEREF ACTA CRYSTALLOGR.,SECT.D V. 70 231 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713026230 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k5y CRHR1 crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 2.98Å AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4l3v CBS crystal structure of delta516-525 human cystathionine beta-synthase 3.63Å AUTH J.ERENO-ORBEA,T.MAJTAN,I.OYENARTE,J.P.KRAUS,AUTH 2 L.A.MARTINEZ-CRUZTITL STRUCTURAL BASIS OF REGULATION AND OLIGOMERIZATION OF HUMANTITL 2 CYSTATHIONINE BETA-SYNTHASE, THE CENTRAL ENZYME OFTITL 3 TRANSSULFURATION.REF PROC.NATL.ACAD.SCI.USA V. 110 E3790 2013REFN ISSN 0027-8424PMID 24043838DOI 10.1073/PNAS.1313683110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ip7 PKLR structure of the s12d variant of human liver pyruvate kinase in complex with citrate and fbp. 1.8Å AUTH T.HOLYOAK,B.ZHANG,J.DENG,Q.TANG,C.B.PRASANNAN,A.W.FENTONTITL ENERGETIC COUPLING BETWEEN AN OXIDIZABLE CYSTEINE AND THETITL 2 PHOSPHORYLATABLE N-TERMINUS OF HUMAN LIVER PYRUVATE KINASE.REF BIOCHEMISTRY V. 52 466 2013REFN ISSN 0006-2960PMID 23270483DOI 10.1021/BI301341R Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1khb PCK1 pepck complex with nonhydrolyzable gtp analog, native data 1.85Å AUTH P.DUNTEN,C.BELUNIS,R.CROWTHER,K.HOLLFELDER,AUTH 2 U.KAMMLOTT,W.LEVIN,H.MICHEL,G.B.RAMSEY,A.SWAIN,AUTH 3 D.WEBER,S.J.WERTHEIMERTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLICTITL 2 PHOSPHOENOLPYRUVATE CARBOXYKINASE REVEALS A NEWTITL 3 GTP-BINDING SITE.REF J.MOL.BIOL. V. 316 257 2002REFN ISSN 0022-2836PMID 11851336DOI 10.1006/JMBI.2001.5364 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants