Assessment of Structural Intolerance and Durability
General Structure Information 1i3d HBG1 human carbonmonoxy hemoglobin barts (gamma4) 1.7Å AUTH R.D.KIDD,H.M.BAKER,A.J.MATHEWS,T.BRITTAIN,E.N.BAKERTITL OLIGOMERIZATION AND LIGAND BINDING IN ATITL 2 HOMOTETRAMERIC HEMOGLOBIN: TWO HIGH-RESOLUTIONTITL 3 CRYSTAL STRUCTURES OF HEMOGLOBIN BARTSTITL 4 (GAMMA(4)), A MARKER FOR ALPHA-THALASSEMIA.REF PROTEIN SCI. V. 10 1739 2001REFN ISSN 0961-8368PMID 11514664DOI 10.1110/PS.11701 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1ncv CCL7 determination cc-chemokine mcp-3, nmr, 7 structures -1.0Å AUTH S.MEUNIER,J.M.BERNASSAU,J.C.GUILLEMOT,P.FERRARA,AUTH 2 H.DARBONTITL DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURETITL 2 OF CC CHEMOKINE MONOCYTE CHEMOATTRACTANT PROTEIN 3TITL 3 BY 1H TWO-DIMENSIONAL NMR SPECTROSCOPY.REF BIOCHEMISTRY V. 36 4412 1997REFN ISSN 0006-2960PMID 9109648DOI 10.1021/BI9627929 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1j1e TNNC1 crystal structure of the 52kda domain of human cardiac troponin in the ca2+ saturated form 3.3Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3l6a EIF4G2 crystal structure of the c-terminal region of human p97 2.0Å AUTH S.FAN,M.JIA,W.GONGTITL CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF HUMANTITL 2 P97/DAP5REF PROTEINS 2010REFN ESSN 1097-0134DOI 10.1002/PROT.22735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1vol GTF2B tfiib (human core domain)/tbp (a.thaliana)/tata element ternary complex 2.7Å AUTH D.B.NIKOLOV,H.CHEN,E.D.HALAY,A.A.USHEVA,K.HISATAKE,AUTH 2 D.K.LEE,R.G.ROEDER,S.K.BURLEYTITL CRYSTAL STRUCTURE OF A TFIIB-TBP-TATA-ELEMENTTITL 2 TERNARY COMPLEX.REF NATURE V. 377 119 1995REFN ISSN 0028-0836PMID 7675079DOI 10.1038/377119A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sf4 GPSM2 crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn 2.6Å AUTH S.YUZAWA,S.KAMAKURA,Y.IWAKIRI,J.HAYASE,H.SUMIMOTOTITL STRUCTURAL BASIS FOR INTERACTION BETWEEN THE CONSERVED CELLTITL 2 POLARITY PROTEINS INSCUTEABLE AND LEU-GLY-ASNTITL 3 REPEAT-ENRICHED PROTEIN (LGN)REF PROC.NATL.ACAD.SCI.USA V. 108 19210 2011REFN ISSN 0027-8424PMID 22074847DOI 10.1073/PNAS.1110951108 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1jsg TCL1A crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b- barrel topology 2.5Å AUTH F.HOH,Y.S.YANG,L.GUIGNARD,A.PADILLA,M.H.STERN,AUTH 2 J.M.LHOSTE,H.VAN TILBEURGHTITL CRYSTAL STRUCTURE OF P14TCL1, AN ONCOGENE PRODUCTTITL 2 INVOLVED IN T-CELL PROLYMPHOCYTIC LEUKEMIA,TITL 3 REVEALS A NOVEL BETA-BARREL TOPOLOGY.REF STRUCTURE V. 6 147 1998REFN ISSN 0969-2126PMID […]
General Structure Information 1o7b TNFAIP6 refined solution structure of the human tsg-6 link module -1.0Å AUTH C.D.BLUNDELL,D.MAHONEY,A.ALMOND,P.DEANGELIS,AUTH 2 J.D.KAHMANN,P.TERIETE,A.R.PICKFORD,I.D.CAMPBELL,AUTH 3 A.J.DAYTITL THE LINK MODULE FROM OVULATION- ANDTITL 2 INFLAMMATION-ASSOCIATED PROTEIN TSG-6 CHANGESTITL 3 CONFORMATION ON HYALURONAN BINDINGREF J.BIOL.CHEM. V. 278 49261 2003REFN ISSN 0021-9258PMID 12972412DOI 10.1074/JBC.M309623200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1pl6 SORD human sdh/nadh/inhibitor complex 2.0Å AUTH T.A.PAULY,J.L.EKSTROM,D.A.BEEBE,B.CHRUNYK,D.CUNNINGHAM,AUTH 2 M.GRIFFOR,A.KAMATH,S.E.LEE,R.MADURA,D.MCGUIRE,T.SUBASHI,AUTH 3 D.WASILKO,P.WATTS,B.L.MYLARI,P.J.OATES,P.D.ADAMS,V.L.RATHTITL X-RAY CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN SORBITOLTITL 2 DEHYDROGENASE.REF STRUCTURE V. 11 1071 2003REFN ISSN 0969-2126PMID 12962626DOI 10.1016/S0969-2126(03)00167-9 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ht6 GEM crystal structure of human gem g-domain bound to gdp 2.4Å AUTH Y.OPATOWSKY,Y.SASSON,I.SHAKED,Y.WARD,AUTH 2 O.CHOMSKY-HECHT,Y.LITVAK,Z.SELINGER,K.KELLY,AUTH 3 J.A.HIRSCHTITL STRUCTURE-FUNCTION STUDIES OF THE G-DOMAIN FROMTITL 2 HUMAN GEM, A NOVEL SMALL G-PROTEIN.REF FEBS LETT. V. 580 5959 2006REFN ISSN 0014-5793PMID 17052716DOI 10.1016/J.FEBSLET.2006.09.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]