General Structure Information
| PDB ID | 2ht6 |
| HGNC Gene Label(s) | GEM |
| Structure Name | crystal structure of human gem g-domain bound to gdp |
| Resolution | 2.4Å |
| Reference | AUTH Y.OPATOWSKY,Y.SASSON,I.SHAKED,Y.WARD,AUTH 2 O.CHOMSKY-HECHT,Y.LITVAK,Z.SELINGER,K.KELLY,AUTH 3 J.A.HIRSCHTITL STRUCTURE-FUNCTION STUDIES OF THE G-DOMAIN FROMTITL 2 HUMAN GEM, A NOVEL SMALL G-PROTEIN.REF FEBS LETT. V. 580 5959 2006REFN ISSN 0014-5793PMID 17052716DOI 10.1016/J.FEBSLET.2006.09.067 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 166 |
| Number Of SNVs | 52 |
| Number Of Permutations | 4419 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.031 |
| p-value | 0.949 |
COSMIC
| Number Of Residues | 166 |
| Number Of SNVs | 4 |
| Number Of Permutations | 121 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.167 |
| p-value | 0.546 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.363 |
| p-value | 0.173 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
