Assessment of Structural Intolerance and Durability
General Structure Information 4msv FASLG crystal structure of fasl and dcr3 complex 2.5Å AUTH W.LIU,U.A.RAMAGOPAL,C.ZHAN,J.B.BONANNO,R.C.BHOSLE,AUTH 2 S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF FASL AND DCR3 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h95 NUDT6 crystal structure of the nudix domain of nudt6 1.7Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTYENOVA,A.KOTZCH,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 6 A.G.THORSELL,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NUDIX DOMAIN OF NUDT6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3lwk CRYBA4 crystal structure of human beta-crystallin a4 (cryba4) 1.7Å AUTH A.CHAIKUAD,N.SHAFQAT,T.KROJER,W.W.YUE,R.COCKING,M.VOLLMAR,AUTH 2 J.R.C.MUNIZ,A.C.W.PIKE,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN BETA-CRYSTALLIN A4 (CRYBA4)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gro PPT1 human palmitoyl-protein thioesterase 1 2.53Å AUTH E.DOBROVETSKY,A.SEITOVA,Y.TONG,W.TEMPEL,A.DONG,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.COSSAR,H.PARKTITL HUMAN PALMITOYL-PROTEIN THIOESTERASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fxt NUDT6 crystal structure of the n-terminal domain of human nudt6 2.3Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,M.I.SIPONEN,A.G.THORSELL,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WIKSTROM,M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN NUDT6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2r2p EPHA5 kinase domain of human ephrin type-a receptor 5 (epha5) 2.4Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f5y RGS3 crystal structure of the pdz domain from human rgs-3 2.39Å AUTH E.UGOCHUKWU,G.BERRIDGE,C.JOHANSSON,C.SMEE,P.SAVITSKY,AUTH 2 N.BURGESS,S.COLEBROOK,X.YANG,J.ELKINS,D.DOYLE,A.TURNBULL,AUTH 3 E.PAPAGRIGORIOU,J.DEBRECZENI,G.BUNKOCZI,F.GORREC,AUTH 4 F.VON DELFT,C.ARROWSMITH,M.SUNDSTROM,J.WEIGELT,A.EDWARDSTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3nr9 CLK2 structure of human cdc2-like kinase 2 (clk2) 2.89Å AUTH A.CHAIKUAD,P.SAVITSKY,T.KROJER,J.R.C.MUNIZ,AUTH 2 P.FILIPPAKOPOULOS,P.RELLOS,T.KEATES,O.FEDOROV,A.C.W.PIKE,AUTH 3 J.ESWARAN,G.BERRIDGE,C.PHILLIPS,Y.ZHANG,F.VON DELFT,AUTH 4 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fbk RGS3 crystal structure of the c2 domain of the human regulator of g-protein signaling 3 isoform 6 (rgp3), northeast structural genomics consortium target hr5550a 2.0Å AUTH F.FOROUHAR,S.LEW,J.SEETHARAMAN,L.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,E.L.FOOTE,R.SHASTRY,J.K.EVERETT,AUTH 3 R.NAIR,T.B.ACTON,B.ROST,G.T.MONTELIONE,J.F.HUNT,AUTH 4 L.TONGTITL CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 3 ISOFORM 6TITL 3 […]
General Structure Information 2gs3 GPX4 crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(gpx4) 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,A.ROJKOVA,O.GILEADI,F.VON DELFT,AUTH 2 C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OFTITL 2 HUMAN GLUTATHIONE PEROXIDASE 4(GPX4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants