General Structure Information 4irq B4GALT7 crystal structure of catalytic domain of human beta1, 4galactosyltransferase 7 in closed conformation in complex with manganese and udp 2.3Å AUTH Y.TSUTSUI,B.RAMAKRISHNAN,P.K.QASBATITL CRYSTAL STRUCTURES OF BETA-1,4-GALACTOSYLTRANSFERASE 7TITL 2 ENZYME REVEAL CONFORMATIONAL CHANGES AND SUBSTRATE BINDING.REF J.BIOL.CHEM. V. 288 31963 2013REFN ISSN 0021-9258PMID 24052259DOI 10.1074/JBC.M113.509984 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3op5 VRK1 human vaccinia-related kinase 1 2.4Å AUTH C.K.ALLERSTON,S.UTTARKAR,P.SAVITSKY,J.M.ELKINS,AUTH 2 P.FILIPPAKOPOULOS,T.KROJER,P.RELLOS,O.FEDOROV,J.ESWARAN,AUTH 3 B.BRENNER,T.KEATES,S.DAS,O.KING,R.CHALK,G.BERRIDGE,AUTH 4 F.VON DELFT,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 5 C.BOUNTRA,S.KNAPPTITL HUMAN VACCINIA-RELATED KINASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3bbt ERBB4 crystal structure of the erbb4 kinase in complex with lapatinib 2.8Å AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yhv PAK1 crystal structure of pak1 kinase domain with two point mutations (k299r, t423e) 1.8Å AUTH M.LEI,M.A.ROBINSON,S.C.HARRISONTITL THE ACTIVE CONFORMATION OF THE PAK1 KINASE DOMAINREF STRUCTURE V. 13 769 2005REFN ISSN 0969-2126PMID 15893667DOI 10.1016/J.STR.2005.03.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pls MST1R ron in complex with ligand amp-pnp 2.24Å AUTH J.WANG,S.STEINBACHER,M.AUGUSTIN,P.SCHREINER,D.EPSTEIN,AUTH 2 M.J.MULVIHILL,A.P.CREWTITL THE CRYSTAL STRUCTURE OF A CONSTITUTIVELY ACTIVE MUTANT RONTITL 2 KINASE SUGGESTS AN INTRAMOLECULAR AUTOPHOSPHORYLATIONTITL 3 HYPOTHESISREF BIOCHEMISTRY V. 49 7972 2010REFN ISSN 0006-2960PMID 20726546 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3rch DDC crystal structure of human aromatic l-amino acid decarboxylase (aadc) in the open conformation with llp and plp bound to chain-a and chain- b respectively 2.8Å AUTH G.GIARDINA,R.MONTIOLI,S.GIANNI,B.CELLINI,A.PAIARDINI,AUTH 2 C.B.VOLTATTORNI,F.CUTRUZZOLATITL OPEN CONFORMATION OF HUMAN DOPA DECARBOXYLASE REVEALS THETITL 2 MECHANISM OF PLP ADDITION TO GROUP II DECARBOXYLASES.REF PROC.NATL.ACAD.SCI.USA V. 108 20514 […]