Assessment of Structural Intolerance and Durability
General Structure Information 2c9y AK2 structure of human adenylate kinase 2 2.1Å AUTH G.BUNKOCZI,P.FILIPPAKOPOULOS,J.E.DEBRECZENI,A.TURNBULL,AUTH 2 E.PAPAGRIGORIOU,P.SAVITSKY,S.COLEBROOK,F.VON DELFT,AUTH 3 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,S.KNAPPTITL STRUCTURE OF HUMAN ADENYLATE KINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1ihi AKR1C2 crystal structure of human type iii 3-alpha-hydroxysteroid dehydrogenase/bile acid binding protein (akr1c2) complexed with nadp+ and ursodeoxycholate 3.0Å AUTH Y.JIN,S.E.STAYROOK,R.H.ALBERT,N.T.PALACKAL,AUTH 2 T.M.PENNING,M.LEWISTITL CRYSTAL STRUCTURE OF HUMAN TYPE IIITITL 2 3ALPHA-HYDROXYSTEROID DEHYDROGENASE/BILE ACIDTITL 3 BINDING PROTEIN COMPLEXED WITH NADP(+) ANDTITL 4 URSODEOXYCHOLATE.REF BIOCHEMISTRY V. 40 10161 2001REFN ISSN 0006-2960PMID 11513593DOI 10.1021/BI010919A […]
General Structure Information 3eto NOTCH1 2 angstrom xray structure of the notch1 negative regulatory region (nrr) 2.0Å AUTH W.R.GORDON,M.ROY,D.VARDAR-ULU,M.GARFINKEL,M.R.MANSOUR,AUTH 2 J.C.ASTER,S.C.BLACKLOWTITL STRUCTURE OF THE NOTCH1-NEGATIVE REGULATORY REGION:TITL 2 IMPLICATIONS FOR NORMAL ACTIVATION AND PATHOGENIC SIGNALINGTITL 3 IN T-ALL.REF BLOOD V. 113 4381 2009REFN ISSN 0006-4971PMID 19075186DOI 10.1182/BLOOD-2008-08-174748 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4kkd MASP1 the x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3mc syndrome 2.6Å AUTH T.YONGQING,P.G.WILMANN,S.B.REEVE,T.H.COETZER,A.I.SMITH,AUTH 2 J.C.WHISSTOCK,R.N.PIKE,L.C.WIJEYEWICKREMATITL THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDINGTITL 2 LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURALTITL 3 BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE CARNEVALE,TITL 4 MINGARELLI, […]
General Structure Information 2wya HMGCS2 crystal structure of human mitochondrial 3-hydroxy-3- methylglutaryl-coenzyme a synthase 2 (hmgcs2) 1.7Å AUTH N.SHAFQAT,A.TURNBULL,J.ZSCHOCKE,U.OPPERMANN,AUTH 2 W.W.YUETITL CRYSTAL STRUCTURES OF HUMAN HMG-COA SYNTHASETITL 2 ISOFORMS PROVIDE INSIGHTS INTO INHERITEDTITL 3 KETOGENESIS DISORDERS AND INHIBITOR DESIGN.REF J.MOL.BIOL. V. 398 497 2010REFN ISSN 0022-2836PMID 20346956DOI 10.1016/J.JMB.2010.03.034 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3t1i MRE11A crystal structure of human mre11: understanding tumorigenic mutations 3.0Å AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h11 TPMT amino-terminal truncated thiopurine s-methyltransferase complexed with s-adenosyl-l-homocysteine 1.89Å AUTH J.R.HORTON,X.CHENGTITL AMINO-TERMINAL TRUNCATED THIOPURINETITL 2 S-METHYLTRANSFERASE COMPLEXED WITHTITL 3 S-ADENOSYL-L-HOMOCYSTEINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nst NDST1 the sulfotransferase domain of human haparin sulfate n- deacetylase/n-sulfotransferase 2.3Å AUTH Y.KAKUTA,T.SUEYOSHI,M.NEGISHI,L.C.PEDERSENTITL CRYSTAL STRUCTURE OF THE SULFOTRANSFERASE DOMAINTITL 2 OF HUMAN HEPARAN SULFATE N-DEACETYLASE/TITL 3 N-SULFOTRANSFERASE 1.REF J.BIOL.CHEM. V. 274 10673 1999REFN ISSN 0021-9258PMID 10196134DOI 10.1074/JBC.274.16.10673 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1wsv AMT crystal structure of human t-protein of glycine cleavage system 2.6Å AUTH K.OKAMURA-IKEDA,H.HOSAKA,M.YOSHIMURA,E.YAMASHITA,AUTH 2 S.TOMA,A.NAKAGAWA,K.FUJIWARA,Y.MOTOKAWA,H.TANIGUCHITITL CRYSTAL STRUCTURE OF HUMAN T-PROTEIN OF GLYCINETITL 2 CLEAVAGE SYSTEM AT 2.0A RESOLUTION AND ITSTITL 3 IMPLICATION FOR UNDERSTANDING NON-KETOTICTITL 4 HYPERGLYCINEMIAREF J.MOL.BIOL. V. 351 1146 2005REFN ISSN 0022-2836PMID 16051266DOI 10.1016/J.JMB.2005.06.056 Variant Set Distributions Ripley’s K […]
General Structure Information 1zbq HSD17B4 crystal structure of human 17-beta-hydroxysteroid dehydrogenase type 4 in complex with nad 2.71Å AUTH P.LUKACIK,N.SHAFQAT,K.KAVANAGH,J.BRAY,F.VON DELFT,A.EDWARDS,AUTH 2 C.ARROWSMITH,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROIDTITL 2 DEHYDROGENASE TYPE 4 IN COMPLEX WITH NADREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants