Assessment of Structural Intolerance and Durability
General Structure Information 4ldq MRI1 crystal structure of the mediator of rho dependent invasion 2.5Å AUTH P.D.TEMPLETON,E.S.LITMAN,S.I.METZNER,N.G.AHN,M.C.SOUSATITL STRUCTURE OF MEDIATOR OF RHOA-DEPENDENT INVASION (MRDI)TITL 2 EXPLAINS ITS DUAL FUNCTION AS A METABOLIC ENZYME AND ATITL 3 MEDIATOR OF CELL INVASION.REF BIOCHEMISTRY V. 52 5675 2013REFN ISSN 0006-2960PMID 23859498DOI 10.1021/BI400556E Variant Set Distributions Mapped Variants
General Structure Information 2h3l ERBB2IP crystal structure of erbin pdz 1.0Å AUTH B.A.APPLETON,Y.ZHANG,P.WU,J.P.YIN,W.HUNZIKER,AUTH 2 N.J.SKELTON,S.S.SIDHU,C.WIESMANNTITL COMPARATIVE STRUCTURAL ANALYSIS OF THE ERBIN PDZTITL 2 DOMAIN AND THE FIRST PDZ DOMAIN OF ZO-1. INSIGHTSTITL 3 INTO DETERMINANTS OF PDZ DOMAIN SPECIFICITY.REF J.BIOL.CHEM. V. 281 22312 2006REFN ISSN 0021-9258PMID 16737969DOI 10.1074/JBC.M602901200 Variant Set Distributions Mapped Variants
General Structure Information 3n1g BOC crystal structure of dhhn bound to bocfn3 1.9Å AUTH J.M.KAVRAN,M.D.WARD,O.O.OLADOSU,S.MULEPATI,D.J.LEAHYTITL ALL MAMMALIAN HEDGEHOG PROTEINS INTERACT WITH CDO AND BOCTITL 2 IN A CONSERVED MANNER.REF J.BIOL.CHEM. 2010REFN ESSN 1083-351XPMID 20519495DOI 10.1074/JBC.M110.131680 Variant Set Distributions Mapped Variants
General Structure Information 2rep KIFC1 crystal structure of the motor domain of human kinesin family member c1 2.6Å AUTH H.ZHU,W.TEMPEL,H.HE,Y.SHEN,J.WANG,G.BROTHERS,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINESINTITL 2 FAMILY MEMBER C1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wmn DOCK9 structure of the complex between dock9 and cdc42-gdp. 2.39Å AUTH J.YANG,Z.ZHANG,S.M.ROE,C.J.MARSHALL,D.BARFORDTITL ACTIVATION OF RHO GTPASES BY DOCK EXCHANGE FACTORSTITL 2 IS MEDIATED BY A NUCLEOTIDE SENSOR.REF SCIENCE V. 325 1398 2009REFN ISSN 0036-8075PMID 19745154DOI 10.1126/SCIENCE.1174468 Variant Set Distributions Mapped Variants
General Structure Information 3d34 SPON2 structure of the f-spondin domain of mindin 1.8Å AUTH Y.LI,C.CAO,W.JIA,L.YU,M.MO,Q.WANG,Y.HUANG,J.M.LIM,AUTH 2 M.ISHIHARA,L.WELLS,P.AZADI,H.ROBINSON,Y.W.HE,AUTH 3 L.ZHANG,R.A.MARIUZZATITL STRUCTURE OF THE F-SPONDIN DOMAIN OF MINDIN, ANTITL 2 INTEGRIN LIGAND AND PATTERN RECOGNITION MOLECULE.REF EMBO J. V. 28 286 2009REFN ISSN 0261-4189PMID 19153605DOI 10.1038/EMBOJ.2008.288 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1ncu TTN titin module m5, n-terminally extended, nmr -1.0Å AUTH M.PFUHL,S.IMPROTA,A.S.POLITOUS,A.PASTORETITL WHEN A MODULE IS ALSO A DOMAIN: THE ROLE OF THE NTITL 2 TERMINUS IN THE STABILITY AND THE DYNAMICS OFTITL 3 IMMUNOGLOBULIN DOMAINS FROM TITIN.REF J.MOL.BIOL. V. 265 242 1997REFN ISSN 0022-2836PMID 9020985DOI 10.1006/JMBI.1996.0725 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4aj5 SKA2 crystal structure of the ska core complex 3.32Å AUTH A.A.JEYAPRAKASH,A.SANTAMARIA,U.JAYACHANDRAN,Y.W.CHAN,AUTH 2 C.BENDA,E.A.NIGG,E.CONTITITL STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE SKA COMPLEX,TITL 2 A KEY COMPONENT OF THE KINETOCHORE-MICROTUBULE INTERFACE.REF MOL.CELL V. 46 274 2012REFN ISSN 1097-2765PMID 22483620DOI 10.1016/J.MOLCEL.2012.03.005 Variant Set Distributions Mapped Variants
General Structure Information 2kg5 ARAP3 nmr solution structure of arap3-sam -1.0Å AUTH M.LEONE,J.CELLITTI,M.PELLECCHIATITL THE SAM DOMAIN OF THE LIPID PHOSPHATASE SHIP2TITL 2 ADOPTS A COMMON MODEL TO INTERACT WITH ARAP3-SAMTITL 3 AND EPHA2-SAM.REF BMC STRUCT.BIOL. V. 9 59 2009REFN ESSN 1472-6807PMID 19765305DOI 10.1186/1472-6807-9-59 Variant Set Distributions Mapped Variants
General Structure Information 1uen NRCAM solution structure of the third fibronectin iii domain of human kiaa0343 protein -1.0Å AUTH K.MIYAMOTO,T.KIGAWA,F.HAYASHI,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD FIBRONECTIN IIITITL 2 DOMAIN OF HUMAN KIAA0343 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants