Assessment of Structural Intolerance and Durability
General Structure Information 2ctm HDLBP solution structure of the 14th kh type i domain from human vigilin -1.0Å AUTH T.TOMIZAWA,T.KIGAWA,S.KOSHIBA,M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH KH TYPE I DOMAINTITL 2 FROM HUMAN VIGILINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1ypo OLR1 human oxidized low density lipoprotein receptor lox-1 p3 1 21 space group 3.0Å AUTH H.PARK,F.G.ADSIT,J.C.BOYINGTONTITL THE 1.4 ANGSTROM CRYSTAL STRUCTURE OF THE HUMANTITL 2 OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR LOX-1.REF J.BIOL.CHEM. V. 280 13593 2005REFN ISSN 0021-9258PMID 15695803DOI 10.1074/JBC.M500768200 Variant Set Distributions Mapped Variants
General Structure Information 1bi8 CDK6 mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1bi8 CDKN2D mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex 2.8Å AUTH A.A.RUSSO,L.TONG,J.O.LEE,P.D.JEFFREY,N.P.PAVLETICHTITL STRUCTURAL BASIS FOR INHIBITION OF THETITL 2 CYCLIN-DEPENDENT KINASE CDK6 BY THE TUMOURTITL 3 SUPPRESSOR P16INK4A.REF NATURE V. 395 237 1998REFN ISSN 0028-0836PMID 9751050DOI 10.1038/26155 Variant Set Distributions Mapped Variants
General Structure Information 2j1k CXADR cav-2 fibre head in complex with car d1 2.3Å AUTH E.SEIRADAKE,H.LORTAT-JACOB,O.BILLET,E.J.KREMER,S.CUSACKTITL STRUCTURAL AND MUTATIONAL ANALYSIS OF HUMAN AD37 AND CANINETITL 2 ADENOVIRUS 2 FIBER HEADS IN COMPLEX WITH THE D1 DOMAIN OFTITL 3 COXSACKIE AND ADENOVIRUS RECEPTOR.REF J.BIOL.CHEM. V. 281 33704 2006REFN ISSN 0021-9258PMID 16923808DOI 10.1074/JBC.M605316200 Variant Set Distributions Mapped […]
General Structure Information 2wno TNFAIP6 x-ray structure of cub_c domain from tsg-6 2.3Å AUTH D.C.BRIGGS,H.L.BIRCHENOUGH,T.ALI,M.S.RUGG,J.P.WALTHO,AUTH 2 E.IEVOLI,T.A.JOWITT,J.J.ENGHILD,R.P.RICHTER,A.SALUSTRI,AUTH 3 C.M.MILNER,A.J.DAYTITL METAL ION-DEPENDENT HEAVY CHAIN TRANSFER ACTIVITY OF TSG-6TITL 2 MEDIATES ASSEMBLY OF THE CUMULUS-OOCYTE MATRIXREF J.BIOL.CHEM. 2015REFN ESSN 1083-351XPMID 26468290DOI 10.1074/JBC.M115.669838 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2br9 YWHAE 14-3-3 protein epsilon (human) complexed to peptide 1.75Å AUTH X.YANG,W.H.LEE,F.SOBOTT,E.PAPAGRIGORIOU,C.V.ROBINSON,AUTH 2 J.G.GROSSMANN,M.SUNDSTROM,D.A.DOYLE,J.M.ELKINSTITL STRUCTURAL BASIS FOR PROTEIN-PROTEIN INTERACTIONS IN THETITL 2 14-3-3 PROTEIN FAMILY.REF PROC.NATL.ACAD.SCI.USA V. 103 17237 2006REFN ISSN 0027-8424PMID 17085597DOI 10.1073/PNAS.0605779103 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2wng SIRPA complete extracellular structure of human signal regulatory protein (sirp) alpha 2.49Å AUTH D.HATHERLEY,S.C.GRAHAM,K.HARLOS,D.I.STUART,AUTH 2 A.N.BARCLAYTITL STRUCTURE OF SIGNAL-REGULATORY PROTEIN ALPHA: ATITL 2 LINK TO ANTIGEN RECEPTOR EVOLUTION.REF J.BIOL.CHEM. V. 284 26613 2009REFN ISSN 0021-9258PMID 19628875DOI 10.1074/JBC.M109.017566 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2v37 CDH13 solution structure of the n-terminal extracellular domain of human t-cadherin -1.0Å AUTH S.A.DAMES,E.J.BANG,D.HAEUSSINGER,T.AHRENS,J.ENGEL,AUTH 2 S.GRZESIEKTITL INSIGHTS INTO THE LOW ADHESIVE CAPACITY OF HUMANTITL 2 T- CADHERIN FROM THE NMR STRUCTURE OF ITSTITL 3 N-TERMINAL EXTRACELLULAR DOMAIN.REF J.BIOL.CHEM. V. 283 23485 2008REFN ISSN 0021-9258PMID 18550521DOI 10.1074/JBC.M708335200 Variant Set Distributions Mapped Variants
General Structure Information 3t6g BCAR1 structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants