Assessment of Structural Intolerance and Durability
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants
General Structure Information 3bua TERF2 crystal structure of trf2 trfh domain and apollo peptide complex 2.5Å AUTH Y.CHEN,Y.YANG,M.VAN OVERBEEK,J.R.DONIGIAN,P.BACIU,AUTH 2 T.DE LANGE,M.LEITITL A SHARED DOCKING MOTIF IN TRF1 AND TRF2 USED FORTITL 2 DIFFERENTIAL RECRUITMENT OF TELOMERIC PROTEINS.REF SCIENCE V. 319 1092 2008REFN ISSN 0036-8075PMID 18202258DOI 10.1126/SCIENCE.1151804 Variant Set Distributions Mapped Variants
General Structure Information 3m1n SHH crystal structure of human sonic hedgehog n-terminal domain 1.85Å AUTH R.B.PEPINSKY,P.RAYHORN,E.S.DAY,A.DERGAY,AUTH 2 K.P.WILLIAMS,A.GALDES,F.R.TAYLOR,AUTH 3 P.A.BORIACK-SJODIN,E.A.GARBERTITL MAPPING SONIC HEDGEHOG-RECEPTOR INTERACTIONS BYTITL 2 STERIC INTERFERENCE.REF J.BIOL.CHEM. V. 275 10995 2000REFN ISSN 0021-9258PMID 10753901DOI 10.1074/JBC.275.15.10995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a63 TP53BP2 crystal structure of the p73-aspp2 complex at 2.6a resolution 2.27Å AUTH P.CANNING,F.VON DELFT,A.N.BULLOCKTITL STRUCTURAL BASIS FOR ASPP2 RECOGNITION BY THE TUMORTITL 2 SUPPRESSOR P73.REF J.MOL.BIOL. V. 423 515 2012REFN ISSN 0022-2836PMID 22917970DOI 10.1016/J.JMB.2012.08.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2k9u FLNC solution nmr structure of the filamin-migfilin complex -1.0Å AUTH S.S.ITHYCHANDA,M.DAS,Y.Q.MA,K.DING,X.WANG,S.GUPTA,C.WU,AUTH 2 E.F.PLOW,J.QINTITL MIGFILIN, A MOLECULAR SWITCH IN REGULATION OF INTEGRINTITL 2 ACTIVATION.REF J.BIOL.CHEM. V. 284 4713 2009REFN ISSN 0021-9258PMID 19074766DOI 10.1074/JBC.M807719200 Variant Set Distributions Mapped Variants
General Structure Information 2r8u MAPRE1 structure of fragment of human end-binding protein 1 (eb1) containing the n-terminal domain at 1.35 a resolution 1.35Å AUTH X.HUANG,L.L.LOVELACE,D.SMITH,L.LEBIODATITL STRUCTURE OF FRAGMENT OF HUMAN END-BINDING PROTEINTITL 2 1 (EB1) CONTAINING THE N-TERMINAL DOMAIN AT 1.35 ATITL 3 RESOLUTIONREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2aze TFDP1 structure of the rb c-terminal domain bound to an e2f1-dp1 heterodimer 2.55Å AUTH S.M.RUBIN,A.L.GALL,N.ZHENG,N.P.PAVLETICHTITL STRUCTURE OF THE RB C-TERMINAL DOMAIN BOUND TOTITL 2 E2F1-DP1: A MECHANISM FOR PHOSPHORYLATION-INDUCEDTITL 3 E2F RELEASE.REF CELL(CAMBRIDGE,MASS.) V. 123 1093 2005REFN ISSN 0092-8674PMID 16360038DOI 10.1016/J.CELL.2005.09.044 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1cf7 TFDP2 structural basis of dna recognition by the heterodimeric cell cycle transcription factor e2f-dp 2.6Å AUTH N.ZHENG,E.FRAENKEL,C.O.PABO,N.P.PAVLETICHTITL STRUCTURAL BASIS OF DNA RECOGNITION BY THETITL 2 HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTORTITL 3 E2F-DP.REF GENES DEV. V. 13 666 1999REFN ISSN 0890-9369PMID 10090723 Variant Set Distributions Mapped Variants
General Structure Information 4f7b SCARB2 structure of the lysosomal domain of limp-2 3.0Å AUTH D.NECULAI,M.SCHWAKE,M.RAVICHANDRAN,F.ZUNKE,R.F.COLLINS,AUTH 2 J.PETERS,M.NECULAI,J.PLUMB,P.LOPPNAU,J.C.PIZARRO,A.SEITOVA,AUTH 3 W.S.TRIMBLE,P.SAFTIG,S.GRINSTEIN,S.DHE-PAGANONTITL STRUCTURE OF LIMP-2 PROVIDES FUNCTIONAL INSIGHTS WITHTITL 2 IMPLICATIONS FOR SR-BI AND CD36.REF NATURE V. 504 172 2013REFN ISSN 0028-0836PMID 24162852DOI 10.1038/NATURE12684 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2k1m MYBPC3 3d nmr structure of domain cc0 of cardiac myosin binding protein c (mybpc) -1.0Å AUTH J.RATTI,M.GAUTEL,M.PFUHLTITL 3D NMR STRUCTURE OF DOMAIN CC0 OF CARDIAC MYOSINTITL 2 BINDING PROTEIN C (MYBPC)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants