Assessment of Structural Intolerance and Durability
General Structure Information 4nf9 CASC5 structure of the knl1/nsl1 complex 2.8Å AUTH A.PETROVIC,S.MOSALAGANTI,J.KELLER,M.MATTIUZZO,K.OVERLACK,AUTH 2 V.KRENN,A.DE ANTONI,S.WOHLGEMUTH,V.CECATIELLO,S.PASQUALATO,AUTH 3 S.RAUNSER,A.MUSACCHIOTITL MODULAR ASSEMBLY OF RWD DOMAINS ON THE MIS12 COMPLEXTITL 2 UNDERLIES OUTER KINETOCHORE ORGANIZATION.REF MOL.CELL V. 53 591 2014REFN ISSN 1097-2765PMID 24530301DOI 10.1016/J.MOLCEL.2014.01.019 Variant Set Distributions Mapped Variants
General Structure Information 4k6j WAPAL human cohesin inhibitor wapl 2.62Å AUTH Z.OUYANG,G.ZHENG,J.SONG,D.M.BOREK,Z.OTWINOWSKI,AUTH 2 C.A.BRAUTIGAM,D.R.TOMCHICK,S.RANKIN,H.YUTITL STRUCTURE OF THE HUMAN COHESIN INHIBITOR WAPL.REF PROC.NATL.ACAD.SCI.USA V. 110 11355 2013REFN ISSN 0027-8424PMID 23776203DOI 10.1073/PNAS.1304594110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iec MARK2 helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates 2.2Å AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4bkf EFNB3 crystal structure of the human epha4 ectodomain in complex with human ephrinb3 4.65Å AUTH E.SEIRADAKE,A.SCHAUPP,D.DEL TORO RUIZ,R.KAUFMANN,AUTH 2 N.MITAKIDIS,K.HARLOS,A.R.ARICESCU,R.KLEIN,E.Y.JONESTITL STRUCTURALLY ENCODED INTRACLASS DIFFERENCES IN EPHATITL 2 CLUSTERS DRIVE DISTINCT CELL RESPONSESREF NAT.STRUCT.MOL.BIOL. V. 20 958 2013REFN ISSN 1545-9993PMID 23812375DOI 10.1038/NSMB.2617 Variant Set Distributions Mapped Variants
General Structure Information 3qbv ITSN1 structure of designed orthogonal interaction between cdc42 and nucleotide exchange domains of intersectin 2.65Å AUTH G.T.KAPP,S.LIU,A.STEIN,D.T.WONG,A.REMENYI,B.J.YEH,AUTH 2 J.S.FRASER,J.TAUNTON,W.A.LIM,T.KORTEMMETITL CONTROL OF PROTEIN SIGNALING USING A COMPUTATIONALLYTITL 2 DESIGNED GTPASE/GEF ORTHOGONAL PAIR.REF PROC.NATL.ACAD.SCI.USA V. 109 5277 2012REFN ISSN 0027-8424PMID 22403064DOI 10.1073/PNAS.1114487109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4gn1 RAPH1 crystal structure of the ra and ph domains of lamellipodin 2.4Å AUTH Y.C.CHANG,H.ZHANG,M.L.BRENNAN,J.WUTITL CRYSTAL STRUCTURE OF LAMELLIPODIN IMPLICATES DIVERSETITL 2 FUNCTIONS IN ACTIN POLYMERIZATION AND RAS SIGNALING.REF PROTEIN CELL V. 4 211 2013REFN ISSN 1674-800XPMID 23483482DOI 10.1007/S13238-013-2082-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3lra LIN7C structural basis for assembling a human tripartite complex dlg1-mpp7- mals3 2.95Å AUTH X.YANG,X.XIE,L.CHEN,H.ZHOU,Z.WANG,W.ZHAO,R.TIAN,R.ZHANG,AUTH 2 C.TIAN,J.LONG,Y.SHENTITL STRUCTURAL BASIS FOR TANDEM L27 DOMAIN-MEDIATEDTITL 2 POLYMERIZATIONREF FASEB J. V. 24 4806 2010REFN ISSN 0892-6638PMID 20702775DOI 10.1096/FJ.10-163857 Variant Set Distributions Mapped Variants
General Structure Information 2l6k TENC1 solution structure of a nonphosphorylated peptide recognizing domain -1.0Å AUTH K.DAI,S.LIAO,J.ZHANG,X.ZHANG,X.TUTITL SOLUTION STRUCTURE OF TENSIN2 SH2 DOMAIN AND ITSTITL 2 PHOSPHOTYROSINE-INDEPENDENT INTERACTION WITH DLC-1REF PLOS ONE V. 6 21965 2011REFN ESSN 1932-6203PMID 21765928DOI 10.1371/JOURNAL.PONE.0021965 Variant Set Distributions Mapped Variants
General Structure Information 1wfn SDK2 the fourth fn3 domain of human sidekick-2 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL THE FOURTH FN3 DOMAIN OF HUMAN SIDEKICK-2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1wf5 SDK2 solution structure of the first fn3 domain of sidekick-2 protein -1.0Å AUTH X.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST FN3 DOMAIN OFTITL 2 SIDEKICK-2 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants