Assessment of Structural Intolerance and Durability
General Structure Information 2ivx CCNT2 crystal structure of human cyclin t2 at 1.8 a resolution (casp target) 1.8Å AUTH S.BAUMLI,G.LOLLI,E.D.LOWE,S.TROIANI,L.RUSCONI,A.N.BULLOCK,AUTH 2 J.E.DEBRECZENI,S.KNAPP,L.N.JOHNSONTITL THE STRUCTURE OF P-TEFB (CDK9/CYCLIN T1), ITS COMPLEX WITHTITL 2 FLAVOPIRIDOL AND REGULATION BY PHOSPHORYLATION.REF EMBO J. V. 27 1907 2008REFN ISSN 0261-4189PMID 18566585DOI 10.1038/EMBOJ.2008.121 Variant Set Distributions Mapped Variants
General Structure Information 3ay5 CCNDBP1 crystal structure of hhm (human homologue of murine maternal id-like molecule) 2.5Å AUTH R.ISHII,K.ISOGAYA,A.SETO,D.KOINUMA,Y.WATANABE,F.ARISAKA,AUTH 2 S.YAGUCHI,H.IKUSHIMA,N.DOHMAE,K.MIYAZONO,K.MIYAZAWA,AUTH 3 R.ISHITANI,O.NUREKITITL STRUCTURE OF A DOMINANT-NEGATIVE HELIX-LOOP-HELIXTITL 2 TRANSCRIPTIONAL REGULATOR SUGGESTS MECHANISMS OFTITL 3 AUTOINHIBITION.REF EMBO J. V. 31 2541 2012REFN ISSN 0261-4189PMID 22453338DOI 10.1038/EMBOJ.2012.77 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3ggr RAD1 crystal structure of the human rad9-hus1-rad1 complex 3.2Å AUTH M.XU,L.BAI,Y.GONG,W.XIE,H.Y.HANG,T.JIANGTITL STRUCTURE AND FUNCTIONAL IMPLICATIONS OF THE HUMANTITL 2 RAD9-HUS1-RAD1 CELL CYCLE CHECKPOINT COMPLEXREF J.BIOL.CHEM. V. 284 20457 2009REFN ISSN 0021-9258PMID 19535328DOI 10.1074/JBC.C109.022384 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3g65 HUS1 crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2wvr GMNN human cdt1:geminin complex 3.3Å AUTH V.DE MARCO,P.J.GILLESPIE,A.LI,N.KARANTZELIS,AUTH 2 E.CHRISTODOULOU,R.KLOMPMAKER,S.VAN GERWEN,A.FISH,AUTH 3 M.V.PETOUKHOV,M.S.ILIOU,Z.LYGEROU,R.H.MEDEMA,AUTH 4 J.J.BLOW,D.I.SVERGUN,S.TARAVIRAS,A.PERRAKISTITL QUATERNARY STRUCTURE OF THE HUMAN CDT1-GEMININTITL 2 COMPLEX REGULATES DNA REPLICATION LICENSING.REF PROC.NATL.ACAD.SCI.USA V. 106 19807 2009REFN ISSN 0027-8424PMID 19906994DOI 10.1073/PNAS.0905281106 Variant Set Distributions Mapped Variants
General Structure Information 4a63 TP73 crystal structure of the p73-aspp2 complex at 2.6a resolution 2.27Å AUTH P.CANNING,F.VON DELFT,A.N.BULLOCKTITL STRUCTURAL BASIS FOR ASPP2 RECOGNITION BY THE TUMORTITL 2 SUPPRESSOR P73.REF J.MOL.BIOL. V. 423 515 2012REFN ISSN 0022-2836PMID 22917970DOI 10.1016/J.JMB.2012.08.005 Variant Set Distributions Mapped Variants
General Structure Information 4a1g BUB1 the crystal structure of the human bub1 tpr domain in complex with the ki motif of knl1 2.6Å AUTH V.KRENN,A.WEHENKEL,X.LI,S.SANTAGUIDA,A.MUSACCHIOTITL STRUCTURAL ANALYSIS REVEALS FEATURES OF THE SPINDLETITL 2 CHECKPOINT KINASE BUB1-KINETOCHORE SUBUNIT KNL1TITL 3 INTERACTION.REF J.CELL BIOL. V. 196 451 2012REFN ISSN 0021-9525PMID 22331848DOI 10.1083/JCB.201110013 Variant Set Distributions Mapped Variants
General Structure Information 4f9a CDC7 human cdc7 kinase in complex with dbf4 and nucleotide 2.17Å AUTH S.HUGHES,F.ELUSTONDO,A.DI FONZO,F.G.LEROUX,A.C.WONG,AUTH 2 A.P.SNIJDERS,S.J.MATTHEWS,P.CHEREPANOVTITL CRYSTAL STRUCTURE OF HUMAN CDC7 KINASE IN COMPLEX WITH ITSTITL 2 ACTIVATOR DBF4.REF NAT.STRUCT.MOL.BIOL. V. 19 1101 2012REFN ISSN 1545-9993PMID 23064647DOI 10.1038/NSMB.2404 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ep8 PES1 solution structure of the brct domain from human pescadillo homolog 1 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE BRCT DOMAIN FROM HUMANTITL 2 PESCADILLO HOMOLOG 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants