3BI6.A | WEE1

General Structure Information 3bi6 WEE1 wee1 kinase complex with inhibitor pd352396 2.2Å AUTH J.B.SMAILL,H.H.LEE,B.D.PALMER,A.M.THOMPSON,AUTH 2 C.J.SQUIRE,E.N.BAKER,R.J.BOOTH,A.KRAKER,K.HOOK,AUTH 3 W.A.DENNYTITL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OFTITL 2 SOLUBLE 8-SUBSTITUTEDTITL 3 4-(2-CHLOROPHENYL)-9-HYDROXYPYRROLO[3,4-TITL 4 C]CARBAZOLE-1,3(2H,6H)-DIONES AS INHIBITORS OF THETITL 5 WEE1 AND CHK1 CHECKPOINT KINASES.REF BIOORG.MED.CHEM.LETT. V. 18 929 2008REFN ISSN 0960-894XPMID 18191399DOI 10.1016/J.BMCL.2007.12.046 Variant Set Distributions Ripley’s K Analysis […]

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3BBB.D | NME2

General Structure Information 3bbb NME2 crystal structure of the nm23-h2 transcription factor complex with dinucleotide d(ag) 1.3Å AUTH T.S.DEXHEIMER,S.S.CAREY,S.ZUOHE,V.M.GOKHALE,X.HU,L.B.MURATA,AUTH 2 E.M.MAES,A.WEICHSEL,D.SUN,E.J.MEUILLET,W.R.MONTFORT,AUTH 3 L.H.HURLEYTITL NM23-H2 MAY PLAY AN INDIRECT ROLE IN TRANSCRIPTIONALTITL 2 ACTIVATION OF C-MYC GENE EXPRESSION BUT DOES NOT CLEAVE THETITL 3 NUCLEASE HYPERSENSITIVE ELEMENT III1.REF MOL.CANCER THER. V. 8 1363 2009REFN ISSN 1535-7163PMID […]

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2KG4.A | GADD45A

General Structure Information 2kg4 GADD45A three-dimensional structure of human gadd45alpha in solution by nmr -1.0Å AUTH R.SANCHEZ,D.PANTOJA-UCEDA,J.PRIETO,T.DIERCKS,M.J.MARCAIDA,AUTH 2 G.MONTOYA,R.CAMPOS-OLIVAS,F.J.BLANCOTITL SOLUTION STRUCTURE OF HUMAN GROWTH ARREST AND DNA DAMAGETITL 2 45ALPHA (GADD45ALPHA) AND ITS INTERACTIONS WITHTITL 3 PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) AND AURORA ATITL 4 KINASEREF J.BIOL.CHEM. V. 285 22196 2010REFN ISSN 0021-9258PMID 20460379DOI 10.1074/JBC.M109.069344 […]

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2W99.A | CCND1

General Structure Information 2w99 CCND1 crystal structure of cdk4 in complex with a d-type cyclin 2.8Å AUTH P.J.DAY,A.CLEASBY,I.J.TICKLE,M.OREILLY,J.E.COYLE,AUTH 2 F.P.HOLDING,R.L.MCMENAMIN,J.YON,R.CHOPRA,AUTH 3 C.LENGAUER,H.JHOTITITL CRYSTAL STRUCTURE OF HUMAN CDK4 IN COMPLEX WITH ATITL 2 D-TYPE CYCLIN.REF PROC.NATL.ACAD.SCI.USA V. 106 4166 2009REFN ISSN 0027-8424PMID 19237565DOI 10.1073/PNAS.0809645106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]

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3EPZ.B | DNMT1

General Structure Information 3epz DNMT1 structure of the replication foci-targeting sequence of human dna cytosine methyltransferase dnmt1 2.31Å AUTH F.SYEDA,R.L.FAGAN,M.WEAN,G.V.AVVAKUMOV,J.R.WALKER,S.XUE,AUTH 2 S.DHE-PAGANON,C.BRENNERTITL THE REPLICATION FOCUS TARGETING SEQUENCE (RFTS) DOMAIN IS ATITL 2 DNA-COMPETITIVE INHIBITOR OF DNMT1.REF J.BIOL.CHEM. V. 286 15344 2011REFN ISSN 0021-9258PMID 21389349DOI 10.1074/JBC.M110.209882 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

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1W98.B | CCNE1

General Structure Information 1w98 CCNE1 the structural basis of cdk2 activation by cyclin e 2.15Å AUTH R.HONDA,E.D.LOWE,E.DUBININA,V.SKAMNAKI,A.COOK,N.BROWN,AUTH 2 L.N.JOHNSONTITL THE STRUCTURE OF CYCLIN E1/CDK2: IMPLICATIONS FOR CDK2TITL 2 ACTIVATION AND CDK2-INDEPENDENT ROLESREF EMBO J. V. 24 452 2005REFN ISSN 0261-4189PMID 15660127DOI 10.1038/SJ.EMBOJ.7600554 Variant Set Distributions Mapped Variants

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2ZOQ.A | MAPK3

General Structure Information 2zoq MAPK3 structural dissection of human mitogen-activated kinase erk1 2.39Å AUTH T.KINOSHITA,I.YOSHIDA,S.NAKAE,K.OKITA,M.GOUDA,AUTH 2 M.MATSUBARA,K.YOKOTA,H.ISHIGURO,T.TADATITL CRYSTAL STRUCTURE OF HUMAN MONO-PHOSPHORYLATEDTITL 2 ERK1 AT TYR204REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 377 1123 2008REFN ISSN 0006-291XPMID 18983981DOI 10.1016/J.BBRC.2008.10.127 Variant Set Distributions Mapped Variants

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3G33.D | CCND3

General Structure Information 3g33 CCND3 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Mapped Variants

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2B9R.B | CCNB1

General Structure Information 2b9r CCNB1 crystal structure of human cyclin b1 2.9Å AUTH E.T.PETRI,A.ERRICO,L.ESCOBEDO,T.HUNT,R.BASAVAPPATITL THE CRYSTAL STRUCTURE OF HUMAN CYCLIN B.REF CELL CYCLE V. 6 1342 2007REFN ISSN 1538-4101PMID 17495533 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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3G33.A | CDK4

General Structure Information 3g33 CDK4 crystal structure of cdk4/cyclin d3 3.0Å AUTH T.TAKAKI,A.ECHALIER,N.R.BROWN,T.HUNT,J.A.ENDICOTT,M.E.NOBLETITL THE STRUCTURE OF CDK4/CYCLIN D3 HAS IMPLICATIONS FOR MODELSTITL 2 OF CDK ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 4171 2009REFN ISSN 0027-8424PMID 19237555DOI 10.1073/PNAS.0809674106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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